Ramipril

Entry

D00421                      Drug

Name

Ramipril (USP/INN);
Altace (TN)

Product

ALTACE (Pfizer Laboratories Div Pfizer)

Generic

RAMIPRIL (A-S Medication Solutions), RAMIPRIL (A-S Medication Solutions), RAMIPRIL (A-S Medication Solutions), RAMIPRIL (A-S Medication Solutions), RAMIPRIL (A-S Medication Solutions), RAMIPRIL (A-S Medication Solutions), RAMIPRIL (A-S Medication Solutions), RAMIPRIL (A-S Medication Solutions), RAMIPRIL (Accord Healthcare), RAMIPRIL (Aurobindo Pharma Limited), RAMIPRIL (BluePoint Laboratories), RAMIPRIL (Bryant Ranch Prepack), RAMIPRIL (Bryant Ranch Prepack), RAMIPRIL (Bryant Ranch Prepack), RAMIPRIL (Bryant Ranch Prepack), RAMIPRIL (Cadila Healthcare Limited), RAMIPRIL (Cadila Healthcare Limited), RAMIPRIL (Chartwell RX), RAMIPRIL (DIRECT RX), RAMIPRIL (DirectRX), RAMIPRIL (Dr. Reddy's Laboratories Limited), RAMIPRIL (Exelan Pharmaceuticals), RAMIPRIL (Hikma Pharmaceuticals USA), RAMIPRIL (Lake Erie Medical DBA Quality Care Products LLC), RAMIPRIL (Lupin Pharmaceuticals), RAMIPRIL (Medsource Pharmaceuticals), RAMIPRIL (Medsource Pharmaceuticals), RAMIPRIL (Northwind Pharmaceuticals), RAMIPRIL (Northwind Pharmaceuticals), RAMIPRIL (Northwind Pharmaceuticals), RAMIPRIL (Proficient Rx LP), RAMIPRIL (Proficient Rx LP), RAMIPRIL (Proficient Rx LP), RAMIPRIL (Proficient Rx LP), RAMIPRIL (Proficient Rx LP), RAMIPRIL (Proficient Rx LP), RAMIPRIL (Proficient Rx LP), RAMIPRIL (REMEDYREPACK), RAMIPRIL (REMEDYREPACK), RAMIPRIL (Rising Health), RAMIPRIL (St. Mary's Medical Park Pharmacy), RAMIPRIL (St. Mary's Medical Park Pharmacy), RAMIPRIL (St. Mary's Medical Park Pharmacy), RAMIPRIL (St. Mary's Medical Park Pharmacy), RAMIPRIL (Zydus Pharmaceuticals (USA)), RAMIPRIL (Zydus Pharmaceuticals (USA))

Formula

C23H32N2O5

Exact mass

416.2311

Mol weight

416.5106

Structure

Simcomp

Class

Cardiovascular agent
DG01925  Renin-angiotensin system inhibitor
  DG01501  Angiotensin-converting enzyme inhibitor
DG03231  Antihypertensive
  DG01501  Angiotensin-converting enzyme inhibitor

Remark

ATC code:

C09AA05

Product:

D00421<US>

Efficacy

Antihypertensive, Angiotensin-converting enzyme inhibitor

Disease

Hypertension [DS:H01633]

Target

ACE (CD143) [HSA:1636] [KO:K01283]

Pathway

hsa04614

Renin-angiotensin system

Interaction

Structure map

map07217

Renin-angiotensin system inhibitors

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09A ACE INHIBITORS, PLAIN
    C09AA ACE inhibitors, plain
     C09AA05 Ramipril
      D00421  Ramipril (USP/INN) <US>
USP drug classification [BR:br08302]
Cardiovascular Agents
  Angiotensin-converting Enzyme (ACE) Inhibitors
   Ramipril
    D00421  Ramipril (USP/INN)
Drug groups [BR:br08330]
Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01501  Angiotensin-converting enzyme inhibitor
    D00421  Ramipril
  DG03231  Antihypertensive
   DG01501  Angiotensin-converting enzyme inhibitor
    D00421  Ramipril
Drug classes [BR:br08332]
Cardiovascular agent
  DG01501  Angiotensin-converting enzyme inhibitor
   D00421  Ramipril
  DG03231  Antihypertensive
   D00421  Ramipril
Target-based classification of drugs [BR:br08310]
Enzymes
  Hydrolases (EC3)
   Peptidyl-dipeptidases
    ACE (CD143)
     D00421  Ramipril (USP/INN) <US>

Other DBs

CAS:	87333-19-5

PubChem:

7847487

ChEBI:

8774

LigandBox:

D00421

NIKKAJI:

J22.246A

KCF data

ATOM        30
            1   N1y N    35.7418  -17.8028
            2   C1y C    37.0644  -18.2769
            3   C1y C    35.7891  -16.4054
            4   C5a C    34.5302  -18.5074
            5   C1y C    37.9147  -17.1669
            6   C1x C    37.8592  -19.4374
            7   C1x C    37.1260  -16.0118
            8   C1c C    33.3189  -17.8085
            9   O5a O    34.5302  -19.9053
            10  C1x C    39.2355  -17.6391
            11  C1x C    39.2716  -19.0378
            12  N1b N    32.1073  -18.5134
            13  C1a C    33.3246  -16.4108
            14  C1c C    30.8959  -17.8144
            15  C1b C    29.6903  -18.5191
            16  C7a C    30.8959  -16.4166
            17  C1b C    28.4789  -17.8318
            18  O7a O    32.1073  -15.7176
            19  O6a O    29.6786  -15.7176
            20  C8y C    27.2790  -18.5250
            21  C1b C    32.0956  -14.3081
            22  C8x C    27.2790  -19.9286
            23  C8x C    26.0676  -17.8318
            24  C1a C    30.8726  -13.6151
            25  C8x C    26.0676  -20.6275
            26  C8x C    24.8560  -18.5250
            27  C8x C    24.8560  -19.9286
            28  C6a C    35.7891  -15.0054
            29  O6a O    36.9978  -14.3074
            30  O6a O    34.5512  -14.2911
BOND        32
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     4   9 2
            9     5  10 1
            10    6  11 1
            11    8  12 1
            12    8  13 1 #Up
            13   12  14 1
            14   14  15 1
            15   14  16 1 #Up
            16   15  17 1
            17   16  18 1
            18   16  19 2
            19   17  20 1
            20   18  21 1
            21   20  22 1
            22   20  23 2
            23   21  24 1
            24   22  25 2
            25   23  26 1
            26   25  27 1
            27    5   7 1
            28   10  11 1
            29   26  27 2
            30    3  28 1 #Down
            31   28  29 1
            32   28  30 2