Ribavirin

Entry

D00423                      Drug

Name

Ribavirin (JP18/USP/INN);
Copegus (TN);
Rebetol (TN);
Ribasphere (TN);
Virazole (TN)

Abbr

RBV

Product

VIRAZOLE (Bausch Health US), RIBAVIRIN (Bryant Ranch Prepack), RIBAVIRIN (Cameron Pharmaceuticals), REBETOL (Merck Sharp & Dohme Corp.), RIBAVIRIN (Oceanside Pharmaceuticals)

Generic

RIBAVIRIN (Aurobindo Pharma Limited), RIBAVIRIN (Aurobindo Pharma Limited), RIBAVIRIN (Cadila Healthcare Limited), RIBAVIRIN (Cadila Healthcare Limited), RIBAVIRIN (Navinta LLC), RIBAVIRIN (Zydus Pharmaceuticals (USA)), RIBAVIRIN (Zydus Pharmaceuticals (USA)), RIBAVIRIN (Zydus Pharmaceuticals USA)

Formula

C8H12N4O5

Exact mass

244.0808

Mol weight

244.2047

Structure

Simcomp

Class

Antiviral
DG01440  Arabinofuranosyl type antiviral
DG03198  Anti-HCV agent
  DG02000  HCV NS5B polymerase inhibitor

Remark

Therapeutic category:

6250

ATC code:

J05AP01

Product:

D00423<JP/US>

Efficacy

Antiviral

Disease

Chronic hepatitis C [DS:H00413]
RSV infection [DS:H00401]

Comment

In combination with peginterferon alfa-2a

Target

HCV NS5B polymerase [KO:K22472]

Pathway

ko03230

Viral genome structure

ko03240

Viral replication

ko05160

Hepatitis C

Interaction

Structure map

map07044

Antiviral agents

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AP Antivirals for treatment of HCV infections
     J05AP01 Ribavirin
      D00423  Ribavirin (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antivirals
  Anti-hepatitis C (HCV) Agents
   Ribavirin
    D00423  Ribavirin (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D00423  Ribavirin (JP18/USP/INN)
Drug groups [BR:br08330]
Antiviral
  DG01440  Arabinofuranosyl type antiviral
   D00423  Ribavirin
  DG03198  Anti-HCV agent
   DG02000  HCV NS5B polymerase inhibitor
    D00423  Ribavirin
Drug classes [BR:br08332]
Antiviral
  DG03198  Anti-HCV agent
   D00423  Ribavirin
Antimicrobials [BR:br08307]
Antivirals
  Genome replication inhibitor
   HCV NS5A/NS5B inhibitor
    D00423  Ribavirin (JP18/USP/INN) <JP/US>
Antimicrobials abbreviations [BR:br08327]
Antivirals
  Genome replication inhibitor
   HCV NS5A/NS5B inhibitor
    D00423  Ribavirin (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00423  Ribavirin
  D00423  Ribavirin capsules
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D00423
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D00423
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D00423

Other DBs

CAS:	36791-04-5

PubChem:

7847489

ChEBI:

63580

PDB-CCD:

RBV[PDBj]

LigandBox:

D00423

NIKKAJI:

J17.798I

KCF data

ATOM        17
            1   N4y N    25.5905  -16.0641
            2   N5x N    26.7827  -16.9056
            3   C1y C    24.3282  -16.4848
            4   C8x C    26.0814  -14.7316
            5   C8y C    27.9047  -16.0641
            6   O2x O    23.1360  -15.6433
            7   C1y C    23.8373  -17.8173
            8   N5x N    27.4840  -14.7316
            9   C5a C    29.1670  -16.6251
            10  C1y C    22.0140  -16.4848
            11  C1y C    22.4347  -17.8173
            12  O1a O    24.6788  -18.9393
            13  N1a N    29.1673  -18.0277
            14  O5a O    30.2891  -15.8537
            15  C1b C    20.6815  -16.0641
            16  O1a O    21.6633  -18.9393
            17  O1a O    19.6297  -16.9757
BOND        18
            1     1   2 1
            2     3   1 1 #Up
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     5   9 1
            9     6  10 1
            10    7  11 1
            11    7  12 1 #Down
            12    9  13 1
            13    9  14 2
            14   10  15 1 #Up
            15   11  16 1 #Down
            16   15  17 1
            17    5   8 1
            18   10  11 1