Entry

D00425                      Drug

Name

Nabumetone (JP18/USP/INN);
Relafen (TN)

Product

Generic

NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Eon Labs), NABUMETONE (A-S Medication Solutions), NABUMETONE (A-S Medication Solutions), NABUMETONE (A-S Medication Solutions), NABUMETONE (A-S Medication Solutions), NABUMETONE (A-S Medication Solutions), NABUMETONE (Actavis Pharma), NABUMETONE (Advanced Rx Pharmacy of Tennessee), NABUMETONE (Advanced Rx Pharmacy of Tennessee), NABUMETONE (Advanced Rx Pharmacy of Tennessee), NABUMETONE (Advanced Rx Pharmacy of Tennessee), NABUMETONE (American Health Packaging), NABUMETONE (Amneal Pharmaceuticals of New York LLC), NABUMETONE (Asclemed USA), RELAFEN (BLUCREST PHARMACEUTICALS LLC), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), NABUMETONE (Bryant Ranch Prepack), RELAFEN DS (Carwin Pharmaceutical Associates), NABUMETONE (Cipla USA), NABUMETONE (DIRECT RX), NABUMETONE (DIRECT RX), NABUMETONE (Denton Pharma), NABUMETONE (Denton Pharma), NABUMETONE (Direct_Rx), NABUMETONE (Direct_Rx), NABUMETONE (Direct_Rx), NABUMETONE (Exelan Pharmaceuticals), NABUMETONE (Glenmark Pharmaceuticals), NABUMETONE (LGM Pharma Solutions), NABUMETONE (Lupin Pharmaceuticals), NABUMETONE (Medsource Pharmaceuticals), NABUMETONE (Medsource Pharmaceuticals), NABUMETONE (Northwind Pharmaceuticals), NABUMETONE (NuCare Pharmaceuticals), NABUMETONE (NuCare Pharmaceuticals), NABUMETONE (PD-Rx Pharmaceuticals), NABUMETONE (PD-Rx Pharmaceuticals), NABUMETONE (PD-Rx Pharmaceuticals), NABUMETONE (PD-Rx Pharmaceuticals), NABUMETONE (Preferred Pharmaceuticals), NABUMETONE (Preferred Pharmaceuticals), NABUMETONE (Proficient Rx LP), NABUMETONE (Proficient Rx LP), NABUMETONE (Proficient Rx LP), NABUMETONE (Proficient Rx LP), NABUMETONE (Proficient Rx LP), NABUMETONE (Proficient Rx LP), NABUMETONE (Quality Care Products), NABUMETONE (Quality Care Products), NABUMETONE (RPK Pharmaceuticals), NABUMETONE (ScieGen Pharmaceuticals), NABUMETONE (St. Mary's Medical Park Pharmacy), NABUMETONE (St. Mary's Medical Park Pharmacy), NABUMETONE (St. Mary's Medical Park Pharmacy), NABUMETONE (St. Mary's Medical Park Pharmacy), NABUMETONE (St.Mary's Medical Park Pharmacy), NABUMETONE (Westminster Pharmaceuticals), NABUMETONE (direct rx), NABUMETONE (medsource pharmaceuticals), NUDROXIPAK N-500 (NuCare Pharmaceuticals)

Formula

C15H16O2

Exact mass

228.115

Mol weight

228.2863

Structure

Class

Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01922 Selective COX2 inhibitor

Remark

Therapeutic category:

1149

ATC code:

M01AX01

Product:

D00425<JP/US>

Efficacy

Analgesic, Anti-inflammatory, COX inhibitor

Target

PTGS2 (COX2) [HSA:5743] [KO:K11987]
PTGS1 (COX1) [HSA:5742] [KO:K00509]

Pathway

hsa00590

Arachidonic acid metabolism

Interaction

Structure map

map07114

Naphthalene family

map07219

Cyclooxygenase inhibitors

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AX Other antiinflammatory and antirheumatic agents, non-steroids
     M01AX01 Nabumetone
      D00425  Nabumetone (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Nabumetone
    D00425  Nabumetone (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D00425  Nabumetone (JP18/USP/INN)
Drug groups [BR:br08330]
Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01922  Selective COX2 inhibitor
    D00425  Nabumetone
Drug classes [BR:br08332]
Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   D00425  Nabumetone
Target-based classification of drugs [BR:br08310]
Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00425  Nabumetone (JP18/USP/INN) <JP/US>
    PTGS2 (COX2)
     D00425  Nabumetone (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00425  Nabumetone
  D00425  Nabumetone tablets

Other DBs

CAS:	42924-53-8

PubChem:

7847491

ChEBI:

7443

PDB-CCD:

NBO[PDBj]

LigandBox:

D00425

NIKKAJI:

J16.442I

KCF data

ATOM        17
            1   C8y C    27.8600  -24.7800
            2   C8y C    27.8600  -26.1800
            3   C8x C    29.0500  -24.0800
            4   C8x C    26.6000  -24.0800
            5   C8x C    26.6000  -26.8800
            6   C8x C    29.0500  -26.8800
            7   C8y C    30.2400  -24.7800
            8   C8x C    25.4100  -24.7800
            9   C8y C    25.4100  -26.1800
            10  C8x C    30.2400  -26.1800
            11  C1b C    31.4300  -24.0800
            12  O2a O    24.2200  -26.8800
            13  C1b C    32.6200  -24.7800
            14  C1a C    22.9600  -26.1800
            15  C5a C    33.8100  -24.0800
            16  C1a C    35.0700  -24.7800
            17  O5a O    33.8100  -22.6800
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     6  10 2
            10    7  11 1
            11    9  12 1
            12   11  13 1
            13   12  14 1
            14   13  15 1
            15   15  16 1
            16   15  17 2
            17    7  10 1
            18    8   9 2