| Entry |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Name | Risperidone (JP18/USP/INN); Risperdal (TN) | ||||||||||||
| Product | RISPERIDONE (Aphena Pharma Solutions - Tennessee), RISPERIDONE (Aphena Pharma Solutions - Tennessee), RISPERIDONE (Aphena Pharma Solutions - Tennessee), RISPERIDONE (Aphena Pharma Solutions - Tennessee), PERSERIS (Indivior), RISPERIDONE (Janssen Pharmaceutical), RISPERIDONE (Janssen Pharmaceuticals), RISPERDAL CONSTA (Janssen Pharmaceuticals), RISPERDAL (REMEDYREPACK) | ||||||||||||
| Generic | RISPERIDONE (A-S Medication Solutions), RISPERIDONE (A-S Medication Solutions), RISPERIDONE (A-S Medication Solutions), RISPERIDONE (ATLANTIC BIOLOGICALS CORP.), RISPERIDONE (Ajanta Pharma USA), RISPERIDONE (American Health Packaging), RISPERIDONE (Amneal Pharmaceuticals LLC), RISPERIDONE (Amneal Pharmaceuticals NY LLC), RISPERIDONE (Aphena Pharma Solutions - Tennessee), RISPERIDONE (Aphena Pharma Solutions - Tennessee), RISPERIDONE (Aphena Pharma Solutions - Tennessee), RISPERIDONE (Aphena Pharma Solutions - Tennessee), RISPERIDONE (Aurobindo Pharma Limited), RISPERIDONE (AvKARE), RISPERIDONE (AvKARE), RISPERIDONE (AvPAK), RISPERIDONE (Bryant Ranch Prepack), RISPERIDONE (Bryant Ranch Prepack), RISPERIDONE (Bryant Ranch Prepack), RISPERIDONE (Bryant Ranch Prepack), RISPERIDONE (Bryant Ranch Prepack), RISPERIDONE (Bryant Ranch Prepack), RISPERIDONE (Bryant Ranch Prepack), RISPERIDONE (Cadila Healthcare Limited), RISPERIDONE (Cadila Healthcare Limited), RISPERIDONE (Cardinal Health), RISPERIDONE (Chartwell RX), RISPERIDONE (Clinical Solutions Wholesale), RISPERIDONE (DIRECT RX), RISPERIDONE (Dr. Reddy's Laboratories Limited), RISPERIDONE (Dr. Reddy's Laboratories Limited), RISPERIDONE (Hikma Pharmaceuticals USA), RISPERIDONE (Jubilant Cadista Pharmaceuticals), RISPERIDONE (Lake Erie Medical DBA Quality Care Products LLC), RISPERIDONE (Lannett Company), RISPERIDONE (Major Pharmaceuticals), RISPERIDONE (NCS HealthCare of KY), RISPERIDONE (NuCare Pharmaceuticals), RISPERIDONE (NuCare Pharmaceuticals), RISPERIDONE (NuCare Pharmaceuticals), RISPERIDONE (PD-Rx Pharmaceuticals), RISPERIDONE (PD-Rx Pharmaceuticals), RISPERIDONE (Preferred Pharmaceuticals), RISPERIDONE (Proficient Rx LP), RISPERIDONE (Proficient Rx LP), RISPERIDONE (Proficient Rx LP), RISPERIDONE (Proficient Rx LP), RISPERIDONE (Proficient Rx LP), RISPERIDONE (Quality Care Products), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (RPK Pharmaceuticals), RISPERIDONE (Solco Healthcare US), RISPERIDONE (Sun Pharmaceutical Industries), RISPERIDONE (Torrent Pharmaceuticals Limited), RISPERIDONE (Tris Pharma), RISPERIDONE (Zydus Pharmaceuticals (USA)), RISPERIDONE (Zydus Pharmaceuticals (USA)) | ||||||||||||
| Formula | C23H27FN4O2 | ||||||||||||
| Exact mass | 410.2118 | ||||||||||||
| Mol weight | 410.4845 | ||||||||||||
| Structure |  | ||||||||||||
| Simcomp | |||||||||||||
| Class | Neuropsychiatric agent DG01478 Dopamine antagonist DG01474 Dopamine D2-receptor antagonist DG03005 Serotonin-dopamine antagonist (SDA) DG03200 Antipsychotic agent DG03064 Atypical antipsychotic Metabolizing enzyme substrate DG01644 CYP2D6 substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate | ||||||||||||
| Remark |
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| Efficacy | Antipsychotic, Neuroleptic | ||||||||||||
| Disease | Schizophrenia [DS:H01649] Bipolar mania [DS:H01653] | ||||||||||||
| Comment | Serotonin-dopamine antagonists (SDA) Active form of prodrug: Paliperidone [DR:D05339] | ||||||||||||
| Target | DRD2 [HSA:1813] [KO:K04145] HTR2A [HSA:3356] [KO:K04157] | ||||||||||||
| Pathway |
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| Metabolism | Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576] | ||||||||||||
| Interaction | |||||||||||||
| Structure map |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] N NERVOUS SYSTEM N05 PSYCHOLEPTICS N05A ANTIPSYCHOTICS N05AX Other antipsychotics N05AX08 Risperidone D00426 Risperidone (JP18/USP/INN) <JP/US> USP drug classification [BR:br08302] Antipsychotics 2nd Generation/Atypical Risperidone D00426 Risperidone (JP18/USP/INN) Bipolar Agents Bipolar Agents, Other Risperidone D00426 Risperidone (JP18/USP/INN) Therapeutic category of drugs in Japan [BR:br08301] 1 Agents affecting nervous system and sensory organs 11 Agents affecting central nervous system 117 Psychotropics 1179 Others D00426 Risperidone (JP18/USP/INN) Drug groups [BR:br08330] Neuropsychiatric agent DG01478 Dopamine antagonist DG01474 Dopamine D2-receptor antagonist D00426 Risperidone DG03005 Serotonin-dopamine antagonist (SDA) D00426 Risperidone DG03200 Antipsychotic agent DG03064 Atypical antipsychotic D00426 Risperidone Metabolizing enzyme substrate DG01644 CYP2D6 substrate D00426 Risperidone DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate D00426 Risperidone Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Rhodopsin family Dopamine DRD2 D00426 Risperidone (JP18/USP/INN) <JP/US> Serotonin HTR2A D00426 Risperidone (JP18/USP/INN) <JP/US> Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D00426 Risperidone D00426 Risperidone tablets D00426 Risperidone fine granules D00426 Risperidone solution New drug approvals in Europe [br08329.html] European public assessment reports (EPAR) authorised medicine D00426 New drug approvals in the USA, Europe and Japan [br08328.html] Approval dates by FDA, EMA and PMDA D00426 Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D00426 Pharmacogenomic biomarkers [br08341.html] Polymorphisms and mutations affecting drug response D00426 Prodrugs [br08324.html] D00426 | ||||||||||||
| Other DBs |
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| KCF data | ATOM 30 1 C1y C 22.2076 -18.2560 2 C1x C 22.2076 -16.8437 3 C1x C 23.4315 -18.9622 4 C1x C 23.4315 -16.1376 5 C1x C 24.6555 -18.2560 6 N1y N 24.6555 -16.8437 7 C1b C 25.8795 -16.1847 8 C1b C 27.0564 -16.8437 9 C8y C 28.2333 -16.1847 10 C8y C 29.4572 -16.8437 11 C8y C 28.2333 -14.7724 12 N4y N 30.6813 -16.1847 13 O5x O 29.4572 -18.2560 14 N5x N 29.4572 -14.0663 15 C1a C 27.0564 -14.0663 16 C8y C 30.6813 -14.7253 17 C1x C 31.9523 -16.8437 18 C1x C 31.9523 -14.0663 19 C1x C 33.1292 -16.1847 20 C1x C 33.1292 -14.7724 21 C8y C 20.9846 -18.9624 22 N5x N 19.8537 -18.1619 23 O2x O 18.7431 -18.9900 24 C8y C 19.1873 -20.3023 25 C8y C 20.5727 -20.2852 26 C8x C 18.4886 -21.5043 27 C8y C 19.1911 -22.7295 28 C8x C 20.6034 -22.7337 29 C8x C 21.3021 -21.5317 30 X F 18.4827 -23.9479 BOND 34 1 1 2 1 2 1 3 1 3 2 4 1 4 3 5 1 5 4 6 1 6 6 7 1 7 7 8 1 8 8 9 1 9 9 10 1 10 9 11 2 11 10 12 1 12 10 13 2 13 11 14 1 14 11 15 1 15 12 16 1 16 12 17 1 17 16 18 1 18 17 19 1 19 18 20 1 20 5 6 1 21 14 16 2 22 19 20 1 23 1 21 1 24 21 22 2 25 22 23 1 26 23 24 1 27 24 25 2 28 21 25 1 29 24 26 1 30 26 27 2 31 27 28 1 32 28 29 2 33 29 25 1 34 27 30 1 |