Entry

D00435                      Drug

Name

Nevirapine (JAN/USP/INN);
Viramune (TN)

Abbr

NVP

Product

VIRAMUNE (Boehringer Ingelheim Pharmaceuticals), VIRAMUNE (Boehringer Ingelheim Pharmaceuticals)

Generic

NEVIRAPINE (Amneal Pharmaceuticals LLC), NEVIRAPINE (Aurobindo Pharma Limited), NEVIRAPINE (Aurobindo Pharma Limited), NEVIRAPINE (Aurobindo Pharma Limited), NEVIRAPINE (Aurobindo Pharma Limited), NEVIRAPINE (Camber Pharmaceuticals), NEVIRAPINE (Macleods Pharmaceuticals Limited), NEVIRAPINE (Macleods Pharmaceuticals Limited), NEVIRAPINE (Micro Labs Limited), NEVIRAPINE (Mylan Pharmaceuticals), NEVIRAPINE (Mylan Pharmaceuticals), NEVIRAPINE (Sandoz), NEVIRAPINE (Strides Pharma Science Limited)

Formula

C15H14N4O

Exact mass

266.1168

Mol weight

266.2979

Structure

Simcomp

Class

Antiviral
DG01889  Non-nucleoside reverse transcriptase inhibitor (NNRTI)
DG03107  Anti-HIV agent
  DG01656  HIV reverse transcriptase inhibitor
Metabolizing enzyme substrate
DG02919  CYP2B6 substrate
DG01644  CYP2D6 substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate

Remark

Same as:

C07263

Therapeutic category:

6250

ATC code:

J05AG01

Product:

D00435<JP/US>

Efficacy

Antiviral, Reverse transcriptase inhibitor

Disease

HIV-1 infection [DS:H01563]

Target

HIV-1 reverse transcriptase [KO:K24802]

Pathway

ko03230

Viral genome structure

ko03240

Viral replication

ko03250

Viral life cycle - HIV-1

Metabolism

Enzyme: CYP3A4 [HSA:1576], CYP2B6 [HSA:1555], CYP2D6 [HSA:1565]

Interaction

Structure map

map07053

Anti-HIV agents

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AG Non-nucleoside reverse transcriptase inhibitors
     J05AG01 Nevirapine
      D00435  Nevirapine (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antivirals
  Anti-HIV Agents, Non-nucleoside Reverse Transcriptase Inhibitors (NNRTI)
   Nevirapine
    D00435  Nevirapine (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D00435  Nevirapine (JAN/USP/INN)
Drug groups [BR:br08330]
Antiviral
  DG01889  Non-nucleoside reverse transcriptase inhibitor (NNRTI)
   D00435  Nevirapine
  DG03107  Anti-HIV agent
   DG01656  HIV reverse transcriptase inhibitor
    D00435  Nevirapine
Metabolizing enzyme substrate
  DG02919  CYP2B6 substrate
   D00435  Nevirapine
  DG01644  CYP2D6 substrate
   D00435  Nevirapine
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D00435  Nevirapine
Drug classes [BR:br08332]
Antiviral
  DG03107  Anti-HIV agent
   D00435  Nevirapine
Antimicrobials [BR:br08307]
Antivirals
  Genome replication inhibitor
   HIV reverse transcriptase inhibitor
    D00435  Nevirapine (JAN/USP/INN) <JP/US>
Antimicrobials abbreviations [BR:br08327]
Antivirals
  Genome replication inhibitor
   HIV reverse transcriptase inhibitor
    D00435  Nevirapine (JAN/USP/INN)
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D00435
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00435

Other DBs

CAS:	129618-40-2

PubChem:

7847501

ChEBI:

63613

PDB-CCD:

NVP[PDBj]

LigandBox:

D00435

NIKKAJI:

J420.601K

KCF data

ATOM        20
            1   C5x C    16.4500  -10.0100
            2   C8y C    15.6100   -8.8900
            3   C8y C    15.9600   -7.5600
            4   N1y N    17.2200   -7.0000
            5   N1x N    17.8500  -10.0100
            6   C8y C    18.4800   -7.6300
            7   C8y C    18.7600   -8.9600
            8   N5x N    14.9100   -6.5800
            9   C8x C    13.5800   -7.0000
            10  C8x C    13.2300   -8.3300
            11  C8x C    14.2800   -9.3100
            12  C8y C    20.0900   -9.3800
            13  C8x C    21.1400   -8.4700
            14  C8x C    20.8600   -7.0700
            15  N5x N    19.5300   -6.6500
            16  O5x O    15.8200  -11.2700
            17  C1y C    17.2200   -5.6000
            18  C1a C    20.3700  -10.7800
            19  C1x C    17.9200   -4.4100
            20  C1x C    16.5200   -4.4100
BOND        23
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    1  16 2
            19    4  17 1
            20   12  18 1
            21   19  20 1
            22   20  17 1
            23   17  19 1