Nizatidine

Entry

D00440                      Drug

Name

Nizatidine (JP18/USP/INN);
Acinon (TN);
Axid (TN)

Product

Generic

NIZATIDINE (Actavis Pharma), NIZATIDINE (Amneal Pharmaceuticals LLC), NIZATIDINE (Amneal Pharmaceuticals LLC), NIZATIDINE (Bryant Ranch Prepack), NIZATIDINE (Bryant Ranch Prepack), NIZATIDINE (Dr Reddy's Laboratories Limited), NIZATIDINE (Glenmark Pharmaceuticals), NIZATIDINE (NuCare Pharmaceuticals), NIZATIDINE (NuCare Pharmaceuticals), NIZATIDINE (Proficient Rx LP)

Formula

C12H21N5O2S2

Exact mass

331.1137

Mol weight

331.4574

Structure

Simcomp

Class

Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01481 Histamine receptor H2 antagonist

Remark

Same as:

C07270

Therapeutic category:

2325

ATC code:

A02BA04

Product:

D00440<JP/US>

Efficacy

Anti-ulcerative, H2 receptor antagonist

Disease

Duodenal ulcer [DS:H01634]
GERD [DS:H01602]
Gastric ulcer [DS:H01634]

Target

HRH2 [HSA:3274] [KO:K04150]

Pathway

hsa04020

Calcium signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04971

Gastric acid secretion

Interaction

Structure map

map07038

Antiulcer drugs

map07227

Histamine H2/H3 receptor agonists/antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BA H2-receptor antagonists
     A02BA04 Nizatidine
      D00440  Nizatidine (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Gastrointestinal Agents
  Histamine2 (H2) Receptor Antagonists
   Nizatidine
    D00440  Nizatidine (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2325  H2 blockers
     D00440  Nizatidine (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for digestive organs
  09 Histamine H2 receptor blocker containing drugs
   D00440  Nizatidine (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
First-class OTC drugs
  Inorganic and organic chemicals
   Nizatidine
    D00440  Nizatidine (JP18/USP/INN)
Drug groups [BR:br08330]
Gastrointestinal agent
  DG01975  Agents for peptic ulcer
   DG01481  Histamine receptor H2 antagonist
    D00440  Nizatidine
Drug classes [BR:br08332]
Gastrointestinal agent
  DG01481  Histamine receptor H2 antagonist
   D00440  Nizatidine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH2
     D00440  Nizatidine (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00440  Nizatidine
  D00440  Nizatidine capsules
Rx-to-OTC switch list in the USA [br08315.html]
D00440
Rx-to-OTC switch list in Japan [br08314.html]
D00440

Other DBs

CAS:	76963-41-2

PubChem:

7847506

ChEBI:

7601

LigandBox:

D00440

NIKKAJI:

J32.887A

KCF data

ATOM        21
            1   C1b C    21.6127  -25.2508
            2   S2a S    22.8717  -24.5514
            3   C1b C    24.0608  -25.2508
            4   C1b C    25.2498  -24.5514
            5   N1b N    26.5088  -25.2508
            6   C2c C    27.6979  -24.5514
            7   C8y C    20.4236  -24.5514
            8   N5x N    20.4236  -23.1525
            9   C8y C    19.0946  -22.7328
            10  S2x S    18.2553  -23.8519
            11  C8x C    19.0946  -24.9710
            12  C1b C    18.6750  -21.4038
            13  C2b C    28.9569  -25.2508
            14  N1c N    17.3091  -21.1017
            15  C1a C    16.3385  -22.1622
            16  C1a C    16.8910  -19.7792
            17  N2b N    30.1567  -24.5315 #+
            18  O3a O    31.3796  -25.2108
            19  O3a O    30.1338  -23.1526 #-
            20  N1b N    27.7512  -23.1705
            21  C1a C    26.5443  -22.4100
BOND        21
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   7 1
            7     7   8 1
            8     8   9 2
            9     9  10 1
            10   10  11 1
            11    7  11 2
            12    9  12 1
            13    6  13 2
            14   12  14 1
            15   14  15 1
            16   14  16 1
            17   13  17 1
            18   17  18 2
            19   17  19 1
            20    6  20 1
            21   20  21 1