Entry

D00453                      Drug

Name

Ofloxacin (JP18/USP/INN);
Floxin (TN)

Product

OCUFLOX (Allergan)

Generic

OFLOXACIN (A-S Medication Solutions), OFLOXACIN (A-S Medication Solutions), OFLOXACIN (A-S Medication Solutions), OFLOXACIN OTIC (A-S Medication Solutions), OFLOXACIN (A-S Medication Solutions), OFLOXACIN (A-S Medication Solutions), OFLOXACIN (A-S Medication Solutions), OFLOXACIN (Akorn), OFLOXACIN OPHTHALMIC (Altaire Pharmaceuticals), OFLOXACIN (Apotex Corp.), OFLOXACIN OTIC (Apotex Corp.), OFLOXACIN (Bausch & Lomb Incorporated), OFLOXACIN (Bausch & Lomb Incorporated), OFLOXACIN OTIC (Bryant Ranch Prepack), OFLOXACIN (Cadila Pharmaceuticals Limited), OFLOXACIN (DIRECT RX), OFLOXACIN OTIC (DIRECT RX), OFLOXACIN (Dr. Reddy's Laboratories Limited), OFLOXACIN (Henry Schein), OFLOXACIN (Larken Laboratories), OFLOXACIN (MWI), OFLOXACIN (Nivagen Pharmaceuticals), OFLOXACIN (NuCare Pharmaceuticaals), OFLOXACIN (NuCare Pharmaceuticals), OFLOXACIN OTIC (NuCare Pharmaceuticals), OFLOXACIN OTIC (NuCare Pharmaceuticals), OFLOXACIN (NuCare Pharmaceuticals), OFLOXACIN (NuCare Pharmaceuticals), OFLOXACIN (NuCare Pharmaceuticals), OFLOXACIN (NuCare Pharmaceuticals), OFLOXACIN (Preferred Pharmaceuticals), OFLOXACIN (Preferred Pharmaceuticals), OFLOXACIN (Preferred Pharmaceuticals), OFLOXACIN OTIC (Proficient Rx LP), OFLOXACIN (Proficient Rx LP), OFLOXACIN (Proficient Rx LP), OFLOXACIN (Proficient Rx LP), OFLOXACIN (Proficient Rx LP), OFLOXACIN (Proficient Rx LP), OFLOXACIN (REMEDYREPACK), OFLOXACIN (RPK Pharmaceuticals), OFLOXACIN (RPK Pharmaceuticals), OFLOXACIN OTIC (RPK Pharmaceuticals), OFLOXACIN (Rising Pharmaceuticals), OFLOXACIN (Rising Pharmaceuticals), OFLOXACIN (A-S Medication Solutions), OFLOXACIN (Amneal Pharmaceuticals NY LLC), OFLOXACIN (Lifestar Pharma LLC), OFLOXACIN (NuCare Pharmaceuticals), OFLOXACIN (A-S Medication Solutions), OFLOXACIN (Hi-Tech Pharmacal), OFLOXACIN (Proficient Rx LP)

Formula

C18H20FN3O4

Exact mass

361.1438

Mol weight

361.3675

Structure

Simcomp

Class

Antibacterial
DG01550  Quinolone
  DG01549  Fluoroquinolone
Metabolizing enzyme substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate

Remark

Same as:

C07321

Therapeutic category:

1319 1329 6241

ATC code:

J01MA01 S01AE01 S02AA16

Chemical structure group:

DG00616

Product (DG00616):

D00453<JP/US>

Efficacy

Antibacterial, Nucleic acid biosynthesis inhibitor

Target

DNA gyrase [KO:K02469 K02470]
topoisomerase IV [KO:K02621 K02622]

Metabolism

Enzyme: CYP3A4 [HSA:1576]

Interaction

Structure map

map07014

Quinolones

Other map

map04976

Bile secretion

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA01 Ofloxacin
      D00453  Ofloxacin (JP18/USP/INN) <JP/US>
S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AE Fluoroquinolones
     S01AE01 Ofloxacin
      D00453  Ofloxacin (JP18/USP/INN) <JP/US>
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA16 Ofloxacin
      D00453  Ofloxacin (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antibacterials
  Quinolones
   Ofloxacin
    D00453  Ofloxacin (JP18/USP/INN)
Ophthalmic Agents
  Ophthalmic Anti-Infectives
   Antibacterials, Ophthalmic
    Ofloxacin
     D00453  Ofloxacin (JP18/USP/INN)
Otic Agents
  Otic Anti-Infectives
   Ofloxacin
    D00453  Ofloxacin (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00453  Ofloxacin (JP18/USP/INN)
   132  Otic and nasal agents
    1329  Others
     D00453  Ofloxacin (JP18/USP/INN)
6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   624  Synthetic antibacterials
    6241  Pyridonecarboxylic acids
     D00453  Ofloxacin (JP18/USP/INN)
Drug groups [BR:br08330]
Antibacterial
  DG01550  Quinolone
   DG01549  Fluoroquinolone
    DG00616  Ofloxacin
     D00453  Ofloxacin
Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00616  Ofloxacin
     D00453  Ofloxacin
Drug classes [BR:br08332]
Antibacterial
  DG01549  Fluoroquinolone
   D00453  Ofloxacin
Antimicrobials [BR:br08307]
Antibacterials
  Nucleic acid synthesis inhibitor
   Fluoroquinolone
    D00453  Ofloxacin (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00453  Ofloxacin
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00453
Drug groups [BR:br08330]
Antibacterial
  DG01550  Quinolone
   DG01549  Fluoroquinolone
    DG00616  Ofloxacin
Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00616  Ofloxacin
Antimicrobials abbreviations [BR:br08327]
Antibacterials
  Nucleic acid synthesis inhibitor
   Fluoroquinolone
    DG00616  Ofloxacin

Other DBs

CAS:	82419-36-1

PubChem:

7847519

ChEBI:

7731

LigandBox:

D00453

NIKKAJI:

J244.886F

KCF data

ATOM        26
            1   C8y C    23.3739  -16.5390
            2   C8y C    22.1610  -17.2388
            3   C8y C    23.3739  -15.1396
            4   N4y N    24.5867  -17.2388
            5   C8y C    20.9481  -16.5390
            6   O2x O    22.1610  -18.6382
            7   C8y C    24.5867  -14.4398
            8   C8x C    22.1610  -14.4398
            9   C8x C    25.7996  -16.5390
            10  C1y C    24.5867  -18.6382
            11  N1y N    19.7353  -17.2388
            12  C8y C    20.9481  -15.1396
            13  C1x C    23.3739  -19.3379
            14  C8y C    25.7996  -15.1396
            15  O5x O    24.5867  -13.0404
            16  C1a C    25.7996  -19.3379
            17  C1x C    18.5224  -16.5390
            18  C1x C    19.7353  -18.6382
            19  X   F    19.7353  -14.4398
            20  C6a C    27.0125  -14.4398
            21  C1x C    17.3095  -17.2388
            22  C1x C    18.5224  -19.3379
            23  O6a O    27.0125  -13.0404
            24  O6a O    28.2253  -15.1396
            25  N1y N    17.3095  -18.6382
            26  C1a C    16.0967  -19.3379
BOND        29
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1
            14    7  15 2
            15   10  16 1
            16   11  17 1
            17   11  18 1
            18   12  19 1
            19   14  20 1
            20   17  21 1
            21   18  22 1
            22   20  23 2
            23   20  24 1
            24   21  25 1
            25   25  26 1
            26    8  12 2
            27    9  14 2
            28   10  13 1
            29   22  25 1