Quinapril hydrochloride


Entry
D00459                      Drug                                   
Name
Quinapril hydrochloride (JP18/USP);
Accupril (TN)
Product
ACCUPRIL (Parke-Davis Div of Pfizer)
  Generic
QUINAPRIL (A-S Medication Solutions), QUINAPRIL (A-S Medication Solutions), QUINAPRIL (A-S Medication Solutions), QUINAPRIL (A-S Medication Solutions), QUINAPRIL (American Health Packaging), QUINAPRIL (BluePoint Laboratories), QUINAPRIL (Bryant Ranch Prepack), QUINAPRIL (Bryant Ranch Prepack), QUINAPRIL (Bryant Ranch Prepack), QUINAPRIL (Bryant Ranch Prepack), QUINAPRIL (Bryant Ranch Prepack), QUINAPRIL (Cipla USA), QUINAPRIL (Denton Pharma), QUINAPRIL (Lupin Pharmaceuticals), QUINAPRIL (Proficient Rx LP), QUINAPRIL (Proficient Rx LP), QUINAPRIL (Proficient Rx LP), QUINAPRIL (Solco Healthcare US), QUINAPRIL (A-S Medication Solutions), QUINAPRIL (Aurobindo Pharma Limited), QUINAPRIL (Bryant Ranch Prepack), QUINAPRIL (Proficient Rx LP)
Formula
C25H30N2O5. HCl
Exact mass
474.1922
Mol weight
474.977
Structure
Simcomp
Class
Cardiovascular agent
 DG01925  Renin-angiotensin system inhibitor
  DG01501  Angiotensin-converting enzyme inhibitor
 DG03231  Antihypertensive
  DG01501  Angiotensin-converting enzyme inhibitor
Remark
Same as: C07340
Therapeutic category: 2144
ATC code: C09AA06
Chemical structure group: DG00338
Product (DG00338): D00459<US>
Product (mixture): D10278<US>
Efficacy
Antihypertensive, Angiotensin-converting enzyme inhibitor
  Disease
Hypertension [DS:H01633]
Comment
Active form of prodrug: Quinaprilat [DR:D03773]
Target
ACE (CD143) [HSA:1636] [KO:K01283]
  Pathway
hsa04614  Renin-angiotensin system
Interaction
Structure map
map07217  Renin-angiotensin system inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09A ACE INHIBITORS, PLAIN
    C09AA ACE inhibitors, plain
     C09AA06 Quinapril
      D00459  Quinapril hydrochloride (JP18/USP) <US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin-converting Enzyme (ACE) Inhibitors
   Quinapril
    D00459  Quinapril hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2144  Angiotensin converting enzyme inhibitors
     D00459  Quinapril hydrochloride (JP18/USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00338  Quinapril
     D00459  Quinapril hydrochloride
  DG03231  Antihypertensive
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00338  Quinapril
     D00459  Quinapril hydrochloride
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01501  Angiotensin-converting enzyme inhibitor
   D00459  Quinapril hydrochloride
  DG03231  Antihypertensive
   D00459  Quinapril hydrochloride
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Peptidyl-dipeptidases
    ACE (CD143)
     D00459  Quinapril hydrochloride (JP18/USP) <US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00459  Quinapril hydrochloride
  D00459  Quinapril hydrochloride tablets
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00338  Quinapril
  DG03231  Antihypertensive
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00338  Quinapril
Prodrugs [br08324.html]
 DG00338
Other DBs
CAS: 82586-55-8
PubChem: 7847525
ChEBI: 8714
LigandBox: D00459
NIKKAJI: J400.159A
KCF data

ATOM        33
            1   C1x C    28.2490  -19.8211
            2   C8y C    29.4582  -19.1183
            3   N1y N    27.0337  -19.1187
            4   C8y C    29.4645  -17.7270
            5   C8x C    30.6604  -19.8200
            6   C1y C    27.0378  -17.7192
            7   C1x C    28.2493  -17.0245
            8   C8x C    30.6680  -17.0343
            9   C8x C    31.8720  -19.1253
            10  C8x C    31.8732  -17.7311
            11  N1b N    23.4099  -19.8234
            12  C1c C    22.1992  -19.1275
            13  C7a C    22.1933  -17.7238
            14  C1b C    20.9826  -19.8351
            15  O7a O    23.4099  -17.0219
            16  O6a O    20.9709  -17.0277
            17  C1b C    19.7661  -19.1450
            18  C1b C    23.4040  -15.6182
            19  C8y C    18.5554  -19.8351
            20  C1a C    22.1875  -14.9223
            21  C8x C    18.5554  -21.2506
            22  C8x C    17.3506  -19.1450
            23  C8x C    17.3506  -21.9582
            24  C8x C    16.1282  -19.8351
            25  C8x C    16.1282  -21.2506
            26  C1c C    24.6167  -19.1187
            27  C5a C    25.8252  -19.8183
            28  O5a O    25.8252  -21.2177
            29  C1a C    24.6140  -17.7194
            30  C6a C    27.0266  -16.3129
            31  O6a O    28.2329  -15.6036
            32  O6a O    25.8093  -15.6229
            33  X   Cl   30.5428  -21.2516
BOND        34
            1     8  10 2
            2     6   7 1
            3     9  10 1
            4    11  12 1
            5    12  13 1 #Up
            6    12  14 1
            7    13  15 1
            8    13  16 2
            9    14  17 1
            10   15  18 1
            11   17  19 1
            12   18  20 1
            13   19  21 1
            14   19  22 2
            15   21  23 2
            16   22  24 1
            17   23  25 1
            18   24  25 2
            19    1   2 1
            20   11  26 1
            21    1   3 1
            22   26  27 1
            23   27   3 1
            24    2   4 2
            25   27  28 2
            26    2   5 1
            27   26  29 1 #Up
            28    3   6 1
            29    6  30 1 #Down
            30    4   7 1
            31   30  31 1
            32    4   8 1
            33   30  32 2
            34    5   9 2