Oxaprozin

Entry

D00463                      Drug

Name

Oxaprozin (JP18/USP/INN);
Daypro (TN)

Product

DAYPRO (Pfizer Laboratories Div Pfizer)

Generic

OXAPROZIN (Amneal Pharmaceuticals NY LLC), OXAPROZIN (Bryant Ranch Prepack), OXAPROZIN (Bryant Ranch Prepack), OXAPROZIN (Bryant Ranch Prepack), OXAPROZIN (Bryant Ranch Prepack), OXAPROZIN (Chartwell RX), OXAPROZIN (DIRECT RX), OXAPROZIN (DIRECT RX), OXAPROZIN (Dr. Reddy's Laboratories Limited), OXAPROZIN (Eon Labs), OXAPROZIN (Greenstone LLC), OXAPROZIN (PD-Rx Pharmaceuticals), OXAPROZIN (St Mary's Medical Park Pharmacy), OXAPROZIN (St. Mary's Medical Park Pharmacy), OXAPROZIN (Teva Pharmaceuticals USA)

Formula

C18H15NO3

Exact mass

293.1052

Mol weight

293.3166

Structure

Simcomp

Class

Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives

Remark

Same as:

C07356

Therapeutic category:

1149

ATC code:

M01AE12

Product:

D00463<JP/US>

Efficacy

Analgesic, Anti-inflammatory, COX inhibitor

Disease

Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]

Comment

Propionic acid derivative

Target

PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]

Pathway

hsa00590

Arachidonic acid metabolism

Interaction

Structure map

map07112

1,2-Diphenyl substitution family

map07219

Cyclooxygenase inhibitors

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AE Propionic acid derivatives
     M01AE12 Oxaprozin
      D00463  Oxaprozin (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Oxaprozin
    D00463  Oxaprozin (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D00463  Oxaprozin (JP18/USP/INN)
Drug groups [BR:br08330]
Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01908  Anti-inflammatory drug, propionic acid derivatives
    D00463  Oxaprozin
Drug classes [BR:br08332]
Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   D00463  Oxaprozin
Target-based classification of drugs [BR:br08310]
Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00463  Oxaprozin (JP18/USP/INN) <JP/US>
    PTGS2 (COX2)
     D00463  Oxaprozin (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00463  Oxaprozin

Other DBs

CAS:	21256-18-8

PubChem:

7847529

ChEBI:

7822

LigandBox:

D00463

NIKKAJI:

J10.781F

KCF data

ATOM        22
            1   C8y C    25.8557  -17.0142
            2   C1b C    27.2577  -17.0142
            3   N5x N    25.0145  -15.8927
            4   C8y C    23.7060  -16.3132
            5   C8y C    23.7060  -17.7152
            6   O2x O    25.0145  -18.1358
            7   C8x C    20.0609  -14.2103
            8   C8x C    20.0609  -15.6123
            9   C8x C    21.2760  -16.3132
            10  C8y C    22.4910  -15.6123
            11  C8x C    22.4910  -14.2103
            12  C8x C    21.2760  -13.5093
            13  C8x C    20.0609  -18.4162
            14  C8x C    20.0609  -19.8181
            15  C8x C    21.2760  -20.5191
            16  C8x C    22.4910  -19.8181
            17  C8y C    22.4910  -18.4162
            18  C8x C    21.2760  -17.7152
            19  C1b C    27.9586  -15.8000
            20  C6a C    29.3606  -15.8000
            21  O6a O    30.0620  -14.5852
            22  O6a O    30.0612  -17.0135
BOND        24
            1     1   2 1
            2     1   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 1
            7     7   8 2
            8     8   9 1
            9     9  10 2
            10   10  11 1
            11   11  12 2
            12    7  12 1
            13   10   4 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17   16  17 1
            18   17  18 2
            19   13  18 1
            20   17   5 1
            21    2  19 1
            22   19  20 1
            23   20  21 1
            24   20  22 2