Prednisolone


Entry
D00472                      Drug                                   
Name
Prednisolone (JP18/USP/INN);
Delta-cortef (TN)
Product
  Generic
PREDNISOLONE (A-S Medication Solutions), PREDNISOLONE (Akorn), MILLIPRED (Avalo Therapeutics), MILLIPRED (Aytu Therapeutics), PREDNISOLONE (DIRECT RX), PREDNISOLONE (Lannett Company), PREDNISOLONE (Preferred Pharmaceuticals), PREDNISOLONE (Proficient Rx LP), PREDNISOLONE (RedPharm Drug)
Formula
C21H28O5
Exact mass
360.1937
Mol weight
360.444
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Same as: C07369
Therapeutic category: 2456 2646
ATC code: A07EA01 C05AA04 D07AA03 D07XA02 H02AB06 R01AD02 S01BA04 S01CB02 S02BA03 S03BA02
Chemical structure group: DG00093
Product (DG00093): D00472<JP/US> D00980<JP/US> D00981<JP/US> D01239<JP> D03301<JP>
Product (mixture): D04251<JP> D04753<JP>
Efficacy
Anti-inflammatory, Antirheumatic, Glucocorticoid receptor agonist
  Disease
Congenital adrenal hyperplasia [DS:H00216]
Psoriatic arthritis [DS:H01507]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Ankylosing spondylitis [DS:H01674]
Systemic lupus erythematosus [DS:H00080]
Pemphigus [DS:H01648]
Bullous dermatitis herpetiformis [DS:H01362]
Erythema multiforme [DS:H01695]
Stevens-Johnson syndrome [DS:H01694]
Mycosis fungoides [DS:H01463]
Psoriasis [DS:H01656]
Seborrheic dermatitis [DS:H01652]
Allergic rhinitis [DS:H01360]
Bronchial asthma [DS:H00079]
Contact dermatitis [DS:H01357]
Atopic dermatitis [DS:H01358]
Optic neuritis [DS:H01717]
Pulmonary tuberculosis [DS:H00342]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Nephrotic syndrome [DS:H01657]
Ulcerative colitis [DS:H01466]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Structure map
map07043  Antineoplastics - hormones
map07046  Immunosuppressive agents
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA01 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA04 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA03 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA02 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB06 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD02 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA04 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB02 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA03 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA02 Prednisolone
      D00472  Prednisolone (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Prednisolone
   D00472  Prednisolone (JP18/USP/INN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Prednisolone
    D00472  Prednisolone (JP18/USP/INN)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Prednisolone
     D00472  Prednisolone (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2456  Prednisolones
     D00472  Prednisolone (JP18/USP/INN)
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D00472  Prednisolone (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00472  Prednisolone (JP18/USP/INN)
 Agents for dental and stomatological use
  74 Stomatitis remedies
   D00472  Prednisolone (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Prednisolone
    D00472  Prednisolone (JP18/USP/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Prednisolone
    D00472  Prednisolone (JP18/USP/INN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
     D00472  Prednisolone
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   D00472  Prednisolone
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D00472  Prednisolone
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00472  Prednisolone (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00472  Prednisolone
  D00472  Prednisolone tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00472
Topical steroids potency [br08317.html]
 Classification in Japan
  D00472
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
Other DBs
CAS: 50-24-8
PubChem: 7847538
ChEBI: 8378
PDB-CCD: TUA[PDBj]
LigandBox: D00472
NIKKAJI: J39.548J
KCF data

ATOM        26
            1   C2x C     5.9500  -12.1800
            2   C5x C     5.9500  -13.5800
            3   C2x C     7.1624  -14.2800
            4   C2y C     8.3749  -13.5800
            5   C1z C     8.3749  -12.1800
            6   C2x C     7.1624  -11.4800
            7   C1x C     9.5873  -14.2800
            8   C1x C    10.7997  -13.5800
            9   C1y C    10.7997  -12.1800
            10  C1y C     9.5873  -11.4800
            11  C1y C    12.0122  -11.4800
            12  C1z C    12.0122  -10.0800
            13  C1x C    10.7997   -9.3800
            14  C1y C     9.5873  -10.0800
            15  C1x C    14.4370  -11.4800
            16  C1x C    14.4370  -10.0800
            17  C1z C    13.2246   -9.3800
            18  O5x O     4.7376  -14.2800
            19  C1a C     8.3749  -10.7800
            20  O1a O     8.3769   -9.3812
            21  C1a C    12.0122   -8.6800
            22  C5a C    13.2246   -7.7700
            23  O1a O    14.4370   -8.6800
            24  C1b C    14.4411   -7.0677
            25  O5a O    12.0162   -7.0723
            26  O1a O    15.6386   -7.7592
BOND        29
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 1 #Up
            24   12  21 1 #Up
            25   17  22 1 #Up
            26   17  23 1 #Down
            27   22  24 1
            28   22  25 2
            29   24  26 1