| Entry |
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|---|---|---|---|---|---|---|---|---|---|---|---|
| Name | Prochlorperazine maleate (JP18/USP); Compazine (TN) | ||||||||||
| Product | |||||||||||
| Generic | PROCHLORPERAZINE (PharmPak), PROCHLORPERAZINE (PharmPak), PROCHLORPERAZINE MALEATE (A-S Medication Solutions), PROCHLORPERAZINE MALEATE (A-S Medication Solutions), PROCHLORPERAZINE MALEATE (A-S Medication Solutions), PROCHLORPERAZINE MALEATE (A-S Medication Solutions), PROCHLORPERAZINE MALEATE (AvKARE), PROCHLORPERAZINE MALEATE (AvPAK), PROCHLORPERAZINE MALEATE (Bryant Ranch Prepack), PROCHLORPERAZINE MALEATE (Bryant Ranch Prepack), PROCHLORPERAZINE MALEATE (Bryant Ranch Prepack), PROCHLORPERAZINE MALEATE (Cadila Healthcare Limited), PROCHLORPERAZINE MALEATE (Cardinal Health), PROCHLORPERAZINE MALEATE (Direct_Rx), PROCHLORPERAZINE MALEATE (JUBILANT CADISTA PHARMACEUTICALS), PROCHLORPERAZINE MALEATE (Mylan Pharmaceuticals), PROCHLORPERAZINE MALEATE (Novitium Pharma LLC), PROCHLORPERAZINE MALEATE (NuCare Pharmaceuticals), PROCHLORPERAZINE MALEATE (NuCare Pharmaceuticals), PROCHLORPERAZINE MALEATE (PD-Rx Pharmaceuticals), PROCHLORPERAZINE MALEATE (Preferred Pharmaceuticlas), PROCHLORPERAZINE MALEATE (Proficient Rx LP), PROCHLORPERAZINE MALEATE (Proficient Rx LP), PROCHLORPERAZINE MALEATE (QPharma), PROCHLORPERAZINE MALEATE (REMEDYREPACK), PROCHLORPERAZINE MALEATE (RedPharm Drug), PROCHLORPERAZINE MALEATE (Zydus Pharmaceuticals (USA)) | ||||||||||
| Formula | C20H24ClN3S. (C4H4O4)2 | ||||||||||
| Exact mass | 605.1599 | ||||||||||
| Mol weight | 606.087 | ||||||||||
| Structure |  | ||||||||||
| Simcomp | |||||||||||
| Class | Neuropsychiatric agent DG01478 Dopamine antagonist DG01474 Dopamine D2-receptor antagonist DG03200 Antipsychotic agent DG01905 Phenothiazine antipsychotics | ||||||||||
| Remark |
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| Efficacy | Antipsychotic, Anti-emetic, Dopamine D2 receptor antagonist | ||||||||||
| Disease | Schizophrenia [DS:H01649] | ||||||||||
| Comment | Phenothiazine derivative | ||||||||||
| Target | DRD2 [HSA:1813] [KO:K04145] | ||||||||||
| Pathway |
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| Interaction | |||||||||||
| Structure map |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] N NERVOUS SYSTEM N05 PSYCHOLEPTICS N05A ANTIPSYCHOTICS N05AB Phenothiazines with piperazine structure N05AB04 Prochlorperazine D00479 Prochlorperazine maleate (JP18/USP) <JP/US> USP drug classification [BR:br08302] Antiemetics Antiemetics, Other Prochlorperazine D00479 Prochlorperazine maleate (JP18/USP) Antipsychotics 1st Generation/Typical Prochlorperazine D00479 Prochlorperazine maleate (JP18/USP) Therapeutic category of drugs in Japan [BR:br08301] 1 Agents affecting nervous system and sensory organs 11 Agents affecting central nervous system 117 Psychotropics 1172 Phenothiazines D00479 Prochlorperazine maleate (JP18/USP) Drug groups [BR:br08330] Neuropsychiatric agent DG01478 Dopamine antagonist DG01474 Dopamine D2-receptor antagonist DG00876 Prochlorperazine D00479 Prochlorperazine maleate DG03200 Antipsychotic agent DG01905 Phenothiazine antipsychotics DG00876 Prochlorperazine D00479 Prochlorperazine maleate Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Rhodopsin family Dopamine DRD2 D00479 Prochlorperazine maleate (JP18/USP) <JP/US> Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D00479 Prochlorperazine maleate D00479 Prochlorperazine maleate tablets Drug groups [BR:br08330] Neuropsychiatric agent DG01478 Dopamine antagonist DG01474 Dopamine D2-receptor antagonist DG00876 Prochlorperazine DG03200 Antipsychotic agent DG01905 Phenothiazine antipsychotics DG00876 Prochlorperazine | ||||||||||
| Other DBs |
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| KCF data | ATOM 41 1 C2b C 39.0699 -17.9328 2 C2b C 37.4396 -17.9386 3 C6a C 39.7454 -19.1089 4 C6a C 36.7699 -19.1205 5 O6a O 39.0756 -20.2792 6 O6a O 41.1078 -19.0915 7 O6a O 35.4074 -19.1205 8 O6a O 37.4510 -20.2909 9 C8x C 22.1200 -19.3900 10 C8x C 22.1200 -20.7900 11 C8x C 23.3100 -21.4900 12 C8y C 24.5700 -20.7900 13 C8y C 24.5700 -19.3900 14 C8x C 23.3100 -18.6900 15 S2x S 25.7600 -21.4900 16 C8y C 26.9500 -20.7900 17 C8y C 26.9500 -19.3900 18 N4y N 25.7600 -18.6900 19 C8x C 28.2100 -21.4900 20 C8x C 29.4000 -20.7900 21 C8y C 29.4000 -19.3900 22 C8x C 28.2100 -18.6900 23 C1b C 25.7600 -17.2900 24 X Cl 30.5900 -18.6900 25 C1b C 26.9500 -16.5900 26 C1b C 28.1400 -17.2900 27 N1y N 29.3300 -16.5900 28 C1x C 30.5200 -17.2900 29 C1x C 31.7800 -16.5900 30 N1y N 31.7800 -15.1900 31 C1x C 30.5900 -14.4900 32 C1x C 29.3300 -15.1900 33 C1a C 32.9700 -14.4900 34 C2b C 39.0699 -17.9328 35 C2b C 37.4396 -17.9386 36 C6a C 36.7699 -19.1205 37 O6a O 35.4074 -19.1205 38 O6a O 37.4510 -20.2909 39 C6a C 39.7454 -19.1089 40 O6a O 39.0756 -20.2792 41 O6a O 41.1078 -19.0915 BOND 42 1 9 10 2 2 10 11 1 3 11 12 2 4 12 13 1 5 13 14 2 6 9 14 1 7 12 15 1 8 15 16 1 9 16 17 1 10 17 18 1 11 13 18 1 12 16 19 2 13 19 20 1 14 20 21 2 15 21 22 1 16 17 22 2 17 18 23 1 18 21 24 1 19 23 25 1 20 25 26 1 21 26 27 1 22 27 28 1 23 28 29 1 24 29 30 1 25 30 31 1 26 31 32 1 27 27 32 1 28 30 33 1 29 1 2 2 30 1 3 1 31 2 4 1 32 3 5 1 33 3 6 2 34 4 7 1 35 4 8 2 36 34 35 2 37 34 39 1 38 35 36 1 39 39 40 1 40 39 41 2 41 36 37 1 42 36 38 2 BRACKET 1 34.1600 -21.1400 34.1600 -16.9400 1 41.6500 -16.9400 41.6500 -21.1400 1 2 ORIGINAL 1 1 2 4 7 8 3 5 6 REPEAT 1 34 35 36 37 38 39 40 41 |