Entry

D00483                      Drug

Name

Propranolol hydrochloride (JP18/USP);
Inderal (TN);
Innopran XL (TN)

Product

INDERAL (ANI Pharmaceuticals), INDERAL XL (ANI Pharmaceuticals), INNOPRAN XL (ANI Pharmaceuticals), HEMANGEOL (Pierre Fabre Pharmaceuticals)

Generic

PROPRANOLOL HCL ER (Direct Rx), PROPRANOLOL HYDROCHLORIDE (A-S Medication Solutions), PROPRANOLOL HYDROCHLORIDE (A-S Medication Solutions), PROPRANOLOL HYDROCHLORIDE (A-S Medication Solutions), PROPRANOLOL HYDROCHLORIDE (A-S Medication Solutions), PROPRANOLOL HYDROCHLORIDE (A-S Medication Solutions), PROPRANOLOL HYDROCHLORIDE (A-S Medication Solutions), PROPRANOLOL HYDROCHLORIDE (AMICI PHARMACEUTICALS LLC), PROPRANOLOL HYDROCHLORIDE (ANI Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (ATLANTIC BIOLOGICALS CORP.), PROPRANOLOL HYDROCHLORIDE (Actavis Pharma), PROPRANOLOL HYDROCHLORIDE (Actavis Pharma), PROPRANOLOL HYDROCHLORIDE (American Health Packaging), PROPRANOLOL HYDROCHLORIDE (American Health Packaging), PROPRANOLOL HYDROCHLORIDE (American Health Packaging), PROPRANOLOL HYDROCHLORIDE (Amneal Pharmaceuticals NY LLC), PROPRANOLOL HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), PROPRANOLOL HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), PROPRANOLOL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), PROPRANOLOL HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), PROPRANOLOL HYDROCHLORIDE (AvKARE), PROPRANOLOL HYDROCHLORIDE (AvPAK), PROPRANOLOL HYDROCHLORIDE (Breckenridge Pharmaceutical), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Bryant Ranch Prepack), PROPRANOLOL HYDROCHLORIDE (Cadila Healthcare Limited), PROPRANOLOL HYDROCHLORIDE (DIRECT RX), PROPRANOLOL HYDROCHLORIDE (DIRECT RX), PROPRANOLOL HYDROCHLORIDE (DOH CENTRAL PHARMACY), PROPRANOLOL HYDROCHLORIDE (Denton Pharma), PROPRANOLOL HYDROCHLORIDE (Direct Rx), PROPRANOLOL HYDROCHLORIDE (Direct_Rx), PROPRANOLOL (Fresenius Kabi USA), PROPRANOLOL HYDROCHLORIDE (General Injectables and Vaccines), PROPRANOLOL HYDROCHLORIDE (Golden State Medical Supply), PROPRANOLOL HYDROCHLORIDE (Golden State Medical Supply), PROPRANOLOL HYDROCHLORIDE (HF Acquisition Co LLC), PROPRANOLOL HYDROCHLORIDE (Henry Schein), PROPRANOLOL HYDROCHLORIDE (Hikma Pharmaceuticals USA), PROPRANOLOL HYDROCHLORIDE (Lannett Company), PROPRANOLOL HYDROCHLORIDE (Major Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Medical Purchasing Solutions), PROPRANOLOL (Medical Purchasing Solutions), PROPRANOLOL HYDROCHLORIDE (Mylan Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (NCS HealthCare of KY), PROPRANOLOL HYDROCHLORIDE (NCS HealthCare of KY), PROPRANOLOL HYDROCHLORIDE (NCS HealthCare of KY), PROPRANOLOL HYDROCHLORIDE (NCS HealthCare of KY), PROPRANOLOL HYDROCHLORIDE (Northwind Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Northwind Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (NuCare Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (NuCare Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (NuCare Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (NuCare Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (NuCare Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (NuCare Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (NuCare Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (NuCare Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (PD-Rx Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (PD-Rx Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Par Pharmaceutical), PROPRANOLOL HYDROCHLORIDE (Pharmaceutical Associates), PROPRANOLOL HYDROCHLORIDE (Preferred Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Preferred Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Preferred Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Preferred Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (Proficient Rx LP), PROPRANOLOL HYDROCHLORIDE (Proficient Rx LP), PROPRANOLOL HYDROCHLORIDE (Proficient Rx LP), PROPRANOLOL HYDROCHLORIDE (Proficient Rx LP), PROPRANOLOL HYDROCHLORIDE (Proficient Rx LP), PROPRANOLOL HYDROCHLORIDE (Quality Care Products), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (REMEDYREPACK), PROPRANOLOL HYDROCHLORIDE (RPK Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (RPK Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (RPK Pharmaceuticals), PROPRANOLOL HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), PROPRANOLOL HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), PROPRANOLOL HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), PROPRANOLOL HYDROCHLORIDE (West Ward Pharmaceuticals Corp.), PROPRANOLOL HYDROCHLORIDE (Zydus Pharmaceuticals (USA))

Formula

C16H21NO2. HCl

Exact mass

295.1339

Mol weight

295.8044

Structure

Simcomp

Class

Cardiovascular agent
DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist (Beta blocker)
DG01653  Antiarrhythmics
  DG01806  Class II antiarrhythmic agent
DG03231  Antihypertensive
Metabolizing enzyme substrate
DG01892  CYP1A2 substrate
DG01639  CYP2C19 substrate
DG01644  CYP2D6 substrate

Remark

Therapeutic category:

2123 2149 2900

ATC code:

C07AA05

Chemical structure group:

DG00305

Product (DG00305):

D00483<JP/US>

Efficacy

Antiarrhythmic, Antihypertensive, Vasodilator, beta-Adrenergic receptor antagonist

Disease

Hypertension [DS:H01633]
Angina pectoris due to coronary atherosclerosis [DS:H01632]
Atrial fibrillation [DS:H00731]
Myocardial infarction [DS:H01730]
Essential tremor [DS:H01577]
Infantile hemangioma [DS:H01482]

Comment

Class II antiarrhythmic agent
Propranolol derivative

Target

ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04261

Adrenergic signaling in cardiomyocytes

Metabolism

Enzyme: CYP2D6 [HSA:1565], CYP1A2 [HSA:1544], CYP2C19 [HSA:1557]

Interaction

Structure map

map07037

Antiarrhythmic drugs

map07048

Antimigraines

map07114

Naphthalene family

map07214

beta-Adrenergic receptor agonists/antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AA Beta blocking agents, non-selective
     C07AA05 Propranolol
      D00483  Propranolol hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Antimigraine Agents
  Antimigraine Agents, Other
   Propranolol
    D00483  Propranolol hydrochloride (JP18/USP)
Cardiovascular Agents
  Antiarrhythmics
   Vaughn Williams-Class II
    Propranolol
     D00483  Propranolol hydrochloride (JP18/USP)
  Beta-adrenergic Blocking Agents
   Non-Selective
    Propranolol
     D00483  Propranolol hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2123  Beta blockers
     D00483  Propranolol hydrochloride (JP18/USP)
   214  Antihypertensives
    2149  Others
     D00483  Propranolol hydrochloride (JP18/USP)
  29  Other agents affecting individual organs
   290  Other agents affecting individual organs
    2900  Other agents affecting individual organs
     D00483  Propranolol hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG01464  beta-Adrenergic receptor antagonist (Beta blocker)
    DG00305  Propranolol
     D00483  Propranolol hydrochloride
  DG01653  Antiarrhythmics
   DG01806  Class II antiarrhythmic agent
    DG00305  Propranolol
     D00483  Propranolol hydrochloride
  DG03231  Antihypertensive
   DG00305  Propranolol
    D00483  Propranolol hydrochloride
Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00305  Propranolol
    D00483  Propranolol hydrochloride
  DG01639  CYP2C19 substrate
   DG00305  Propranolol
    D00483  Propranolol hydrochloride
  DG01644  CYP2D6 substrate
   DG00305  Propranolol
    D00483  Propranolol hydrochloride
Drug classes [BR:br08332]
Cardiovascular agent
  DG03231  Antihypertensive
   D00483  Propranolol hydrochloride
  DG01653  Antiarrhythmics
   D00483  Propranolol hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRB
     D00483  Propranolol hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00483  Propranolol hydrochloride
  D00483  Propranolol hydrochloride tablets
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D00483
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00483
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
  D00483
Drug groups [BR:br08330]
Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG01464  beta-Adrenergic receptor antagonist (Beta blocker)
    DG00305  Propranolol
  DG01653  Antiarrhythmics
   DG01806  Class II antiarrhythmic agent
    DG00305  Propranolol
  DG03231  Antihypertensive
   DG00305  Propranolol
Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00305  Propranolol
  DG01639  CYP2C19 substrate
   DG00305  Propranolol
  DG01644  CYP2D6 substrate
   DG00305  Propranolol

Other DBs

CAS:

318-98-9

PubChem:

7847549

ChEBI:

8500

LigandBox:

D00483

NIKKAJI:

J262.867H

KCF data

ATOM        20
            1   C8x C     7.6300  -12.9500
            2   C8x C     7.6300  -14.3500
            3   C8x C     8.8424  -15.0500
            4   C8y C    10.0549  -14.3500
            5   C8y C    10.0549  -12.9500
            6   C8x C     8.8424  -12.2500
            7   C8x C    11.2673  -15.0500
            8   C8x C    12.4797  -14.3500
            9   C8x C    12.4797  -12.9500
            10  C8y C    11.2673  -12.2500
            11  O2a O    11.2673  -10.8500
            12  C1b C    12.4818  -10.1488
            13  C1c C    13.6783  -10.8398
            14  C1b C    14.8651  -10.1546
            15  O1a O    13.6784  -12.2497
            16  N1b N    16.0566  -10.8428
            17  C1c C    17.2460  -10.1561
            18  C1a C    18.4362  -10.8435
            19  C1a C    17.2462   -8.7502
            20  X   Cl   18.7600  -14.2800
BOND        20
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12   10  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   13  15 1
            17   14  16 1
            18   16  17 1
            19   17  18 1
            20   17  19 1