Perphenazine


Entry
D00503                      Drug                                   
Name
Perphenazine (JP18/USP/INN);
Trilafon (TN)
Product
  Generic
PERPHENAZINE (Actavis Pharma), PERPHENAZINE (American Health Packaging), PERPHENAZINE (Bryant Ranch Prepack), PERPHENAZINE (Bryant Ranch Prepack), PERPHENAZINE (Bryant Ranch Prepack), PERPHENAZINE (Bryant Ranch Prepack), PERPHENAZINE (Bryant Ranch Prepack), PERPHENAZINE (Bryant Ranch Prepack), PERPHENAZINE (Bryant Ranch Prepack), PERPHENAZINE (Cadila Healthcare Limited), PERPHENAZINE (DOH CENTRAL PHARMACY), PERPHENAZINE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), PERPHENAZINE (Major Pharmaceuticals), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (REMEDYREPACK), PERPHENAZINE (Rising Pharmaceuticals), PERPHENAZINE (Sandoz), PERPHENAZINE (Wilshire Pharmaceuticals), PERPHENAZINE (Zydus Pharmaceuticals (USA))
Formula
C21H26ClN3OS
Exact mass
403.1485
Mol weight
403.9686
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
 DG03200  Antipsychotic agent
  DG01905  Phenothiazine antipsychotics
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
Remark
Same as: C07427
Therapeutic category: 1172
ATC code: N05AB03
Chemical structure group: DG00875
Product (DG00875): D00503<JP/US> D02037<JP> D04038<JP> D04965<JP>
Product (mixture): D10294<US>
Efficacy
Antipsychotic, Dopamine D2 receptor antagonist
  Disease
Schizophrenia [DS:H01649]
Comment
Phenothiazine derivative
Target
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Structure map
map07029  Antipsychotics - phenothiazines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AB Phenothiazines with piperazine structure
     N05AB03 Perphenazine
      D00503  Perphenazine (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Perphenazine
    D00503  Perphenazine (JP18/USP/INN)
 Antipsychotics
  1st Generation/Typical
   Perphenazine
    D00503  Perphenazine (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1172  Phenothiazines
     D00503  Perphenazine (JP18/USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00875  Perphenazine
     D00503  Perphenazine
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG00875  Perphenazine
     D00503  Perphenazine
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00875  Perphenazine
    D00503  Perphenazine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D00503  Perphenazine (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00503  Perphenazine
  D00503  Perphenazine tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00503
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00503
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00875  Perphenazine
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG00875  Perphenazine
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00875  Perphenazine
Other DBs
CAS: 58-39-9
PubChem: 7847569
ChEBI: 8028
LigandBox: D00503
NIKKAJI: J1.387K
KCF data

ATOM        27
            1   C8x C    16.1000  -11.4100
            2   C8x C    16.1000  -12.8100
            3   C8x C    17.3124  -13.5100
            4   C8y C    18.5249  -12.8100
            5   C8y C    18.5249  -11.4100
            6   C8x C    17.3124  -10.7100
            7   S2x S    19.7373  -13.5100
            8   C8y C    20.9497  -12.8100
            9   C8y C    20.9497  -11.4100
            10  N4y N    19.7373  -10.7100
            11  C8x C    22.1622  -13.5100
            12  C8x C    23.3746  -12.8100
            13  C8y C    23.3746  -11.4100
            14  C8x C    22.1622  -10.7100
            15  C1b C    19.7373   -9.3100
            16  C1b C    20.9518   -8.6088
            17  C1b C    22.1483   -9.2998
            18  N1y N    23.3351   -8.6146
            19  C1x C    24.5266   -9.3028
            20  C1x C    25.7391   -8.6029
            21  N1y N    25.7393   -7.2029
            22  C1x C    24.5478   -6.5148
            23  C1x C    23.3353   -7.2146
            24  C1b C    26.9641   -6.4958
            25  C1b C    28.1720   -7.1932
            26  O1a O    29.3532   -6.5113
            27  X   Cl   24.5911  -10.7077
BOND        30
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    8  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16    9  14 2
            17   10  15 1
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   18  23 1
            27   21  24 1
            28   24  25 1
            29   25  26 1
            30   13  27 1