Entry

D00516                      Drug

Name

Isosorbide dinitrate (JP18/USP/INN);
Dilatrate-sr (TN);
Isordil (TN)

Product

ISORDIL (Bausch Health US LLC), ISOSORBIDE DINITRATE (Oceanside Pharmaceuticals)

Generic

ISOSORBIDE DINITRATE (Advagen Pharma), ISOSORBIDE DINITRATE (American Health Packaging), ISOSORBIDE DINITRATE (Aphena Pharma Solutions - Tennessee), ISOSORBIDE DINITRATE (AvKARE), ISOSORBIDE DINITRATE (AvPAK), ISOSORBIDE (BluePoint Laboratories), ISOSORBIDE DINITRATE (Bryant Ranch Prepack), ISOSORBIDE DINITRATE (Cadila Healthcare Limited), ISOSORBIDE DINITRATE (Cardinal Health), ISOSORBIDE DINITRATE (Golden State Medical Supply), ISOSORBIDE DINITRATE (Hikma Pharmaceuticals USA), ISOSORBIDE DINITRATE (Major Pharmaceuticals), ISOSORBIDE DINITRATE (McKesson Corporation dba SKY Packaging), ISOSORBIDE DINITRATE (NCS HealthCare of KY), ISOSORBIDE DINITRATE (Northstar Rx LLC), ISOSORBIDE DINITRATE (Par Pharmaceutical), ISOSORBIDE DINITRATE (Par Pharmaceutical), ISOSORBIDE DINITRATE (REMEDYREPACK), ISOSORBIDE DINITRATE (REMEDYREPACK), ISOSORBIDE DINITRATE (REMEDYREPACK), ISOSORBIDE DINITRATE (REMEDYREPACK), ISOSORBIDE DINITRATE (REMEDYREPACK), ISOSORBIDE DINITRATE (Sandoz), ISOSORBIDE DINITRATE (Zydus Pharmaceuticals (USA))

Formula

C6H8N2O8

Exact mass

236.0281

Mol weight

236.1363

Structure

Simcomp

Class

Cardiovascular agent
DG01657 Nitrovasodilator

Remark

Same as:

C07456

Therapeutic category:

2171

ATC code:

C01DA08 C05AE02

Chemical structure group:

DG01270

Product (DG01270):

D00516<JP/US> D00630<JP/US>

Product (mixture):

D10209<US>

Efficacy

Vasodilator (coronary)

Disease

Angina pectoris [DS:H01632]

Comment

Organic nitrate
Osmotic diuretics
Nitric oxide donor

Interaction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01D VASODILATORS USED IN CARDIAC DISEASES
    C01DA Organic nitrates
     C01DA08 Isosorbide dinitrate
      D00516  Isosorbide dinitrate (JP18/USP/INN) <JP/US>
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AE Muscle relaxants
     C05AE02 Isosorbide dinitrate
      D00516  Isosorbide dinitrate (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
  Vasodilators
   Direct-acting Arterial/Venous
    Isosorbide Dinitrate
     D00516  Isosorbide dinitrate (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  21  Cardiovascular agents
   217  Vasodilators
    2171  Coronary dilators
     D00516  Isosorbide dinitrate (JP18/USP/INN)
Drug groups [BR:br08330]
Cardiovascular agent
  DG01657  Nitrovasodilator
   DG01270  Isosorbide nitrate
    D00516  Isosorbide dinitrate
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00516  Isosorbide dinitrate
  D00516  Isosorbide dinitrate tablets
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
  D00516
Drug groups [BR:br08330]
Cardiovascular agent
  DG01657  Nitrovasodilator
   DG01270  Isosorbide nitrate

Other DBs

CAS:

87-33-2

PubChem:

7847582

ChEBI:

6061

LigandBox:

D00516

NIKKAJI:

J3.899G

KCF data

ATOM        16
            1   C1y C    20.6734  -17.3108
            2   C1y C    20.6734  -15.9089
            3   C1y C    19.3401  -15.4757
            4   C1x C    18.5160  -16.6098
            5   O2x O    19.3401  -17.7440
            6   C1y C    22.0067  -17.7440
            7   C1x C    22.8307  -16.6098
            8   O2x O    22.0067  -15.4757
            9   O2a O    22.4361  -19.0654
            10  O2a O    18.9107  -14.1543
            11  N2b N    17.4407  -14.1543 #+
            12  O3a O    16.7319  -12.9265 #-
            13  O3a O    16.7441  -15.3605
            14  N2b N    23.8361  -19.0654 #+
            15  O3a O    24.5334  -20.2728 #-
            16  O3a O    24.5550  -17.7490
BOND        17
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     1   6 1
            7     6   7 1
            8     7   8 1
            9     2   8 1
            10    6   9 1 #Up
            11    3  10 1 #Down
            12   10  11 1
            13   11  12 1
            14   11  13 2
            15    9  14 1
            16   14  15 1
            17   14  16 2