Entry

D00538                      Drug

Name

Zonisamide (JP18/USP/INN);
Excegran (TN)

Product

ZONISADE (Azurity Phramaceuticals), ZONEGRAN (Concordia Pharmaceuticals)

Generic

ZONISAMIDE (American Health Packaging), ZONISAMIDE (Aurobindo Pharma Limited), ZONISAMIDE (AvPAK), ZONISAMIDE (BluePoint Laboratories), ZONISAMIDE (Bryant Ranch Prepack), ZONISAMIDE (Bryant Ranch Prepack), ZONISAMIDE (Bryant Ranch Prepack), ZONISAMIDE (Bryant Ranch Prepack), ZONISAMIDE (Cadila Healthcare Limited), ZONISAMIDE (Cipla USA), ZONISAMIDE (DIRECT RX), ZONISAMIDE (Direct_Rx), ZONISAMIDE (Direct_Rx), ZONISAMIDE (Direct_Rx), ZONISAMIDE (Exelan Pharmaceuticals), ZONISAMIDE (Glenmark Pharmaceuticals), ZONISAMIDE (Golden State Medical Supply), ZONISAMIDE (NCS HealthCare of KY), ZONISAMIDE (NuCare Pharmaceuticals), ZONISAMIDE (PD-Rx Pharmaceuticals), ZONISAMIDE (Preferred Pharmaceuticals), ZONISAMIDE (Proficient Rx LP), ZONISAMIDE (Proficient Rx LP), ZONISAMIDE (Quality Care Products LLC), ZONISAMIDE (REMEDYREPACK), ZONISAMIDE (REMEDYREPACK), ZONISAMIDE (Sun Pharmaceutical Industries), ZONISAMIDE (Unichem Pharmaceuticals (USA)), ZONISAMIDE (Viona Pharmaceuticals)

Formula

C8H8N2O3S

Exact mass

212.0256

Mol weight

212.2257

Structure

Simcomp

Class

Cardiovascular agent
DG01575  Calcium channel blocker
  DG01573  Calcium channel T type blocker
Neuropsychiatric agent
DG03199  Antiepileptic agent
Metabolizing enzyme substrate
DG01633  CYP3A/CYP3A4 substrate

Remark

Same as:

C07504

Therapeutic category:

1139 1169

ATC code:

N03AX15

Product:

D00538<JP/US>

Efficacy

Anticonvulsant, Antiepileptic

Comment

Benzisoxazole derivative

Target

SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
CACNA1-T [HSA:8911 8912 8913] [KO:K04856 K04855 K04854]

Pathway

hsa04010

MAPK signaling pathway

hsa04020

Calcium signaling pathway

hsa04728

Dopaminergic synapse

Metabolism

Enzyme: CYP3A [HSA:1576 1577 1551]

Interaction

Structure map

map07033

Anticonvulsants

map07057

Antiparkinsonian agents

map07231

Sodium channel blocking drugs

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX15 Zonisamide
      D00538  Zonisamide (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Anticonvulsants
  Sodium Channel Agents
   Zonisamide
    D00538  Zonisamide (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D00538  Zonisamide (JP18/USP/INN)
   116  Antiparkinsonian agents
    1169  Others
     D00538  Zonisamide (JP18/USP/INN)
Drug groups [BR:br08330]
Cardiovascular agent
  DG01575  Calcium channel blocker
   DG01573  Calcium channel T type blocker
    D00538  Zonisamide
Neuropsychiatric agent
  DG03199  Antiepileptic agent
   D00538  Zonisamide
Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   D00538  Zonisamide
Target-based classification of drugs [BR:br08310]
Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN2A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN3A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN4A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN5A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN8A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN9A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN10A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN11A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
   Calcium channels
    CACNA1-T
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00538  Zonisamide
  D00538  Zonisamide tablets
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D00538
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D00538
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D00538
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00538

Other DBs

CAS:	68291-97-4

PubChem:

7847604

ChEBI:

10127

PDB-CCD:

ZON[PDBj]

LigandBox:

D00538

NIKKAJI:

J20.559A

KCF data

ATOM        14
            1   C8y C    23.2246  -18.0420
            2   C8y C    24.5519  -17.6112
            3   C8y C    23.2246  -19.4447
            4   C8x C    22.0139  -17.3435
            5   N5x N    25.3783  -18.7462
            6   O2x O    24.5576  -19.8813
            7   C8x C    22.0139  -20.1433
            8   C8x C    20.7973  -18.0420
            9   C8x C    20.7973  -19.4447
            10  C1b C    24.5519  -16.2112
            11  S4a S    25.7651  -15.5107
            12  O3c O    26.9775  -14.8107
            13  N1a N    25.0763  -14.3183
            14  O3c O    26.4767  -16.7426
BOND        15
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     7   9 2
            9     5   6 1
            10    8   9 1
            11    2  10 1
            12   10  11 1
            13   11  12 2
            14   11  13 1
            15   11  14 2