Entry

D00539                      Drug

Name

Ethosuximide (JP18/USP/INN);
Zarontin (TN)

Product

ZARONTIN (Parke-Davis Div of Pfizer)

Generic

ETHOSUXIMIDE (Akorn), ETHOSUXIMIDE (Bionpharma), ETHOSUXIMIDE (Bryant Ranch Prepack), ETHOSUXIMIDE (Bryant Ranch Prepack), ETHOSUXIMIDE (Epic Pharma), ETHOSUXIMIDE (Greenstone LLC), ETHOSUXIMIDE (Greenstone LLC), ETHOSUXIMIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), ZARONTIN (Parke-Davis Div of Pfizer), ETHOSUXIMIDE (Pharmaceutical Associates), ETHOSUXIMIDE (Strides Pharma Science Limited)

Formula

C7H11NO2

Exact mass

141.079

Mol weight

141.1677

Structure

Simcomp

Class

Cardiovascular agent
DG01575  Calcium channel blocker
  DG01573  Calcium channel T type blocker
Neuropsychiatric agent
DG03199  Antiepileptic agent
  DG02033  Succinimide antiepileptic
Metabolizing enzyme substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate

Remark

Same as:

C07505

Therapeutic category:

1139

ATC code:

N03AD01

Product:

D00539<JP/US>

Efficacy

Antiepileptic

Comment

Succinimide derivative

Target

CACNA1-T [HSA:8911 8912 8913] [KO:K04856 K04855 K04854]

Pathway

hsa04010

MAPK signaling pathway

hsa04020

Calcium signaling pathway

Metabolism

Enzyme: CYP3A4 [HSA:1576]

Interaction

Structure map

map07033

Anticonvulsants

map07036

Calcium channel blocking drugs

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AD Succinimide derivatives
     N03AD01 Ethosuximide
      D00539  Ethosuximide (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Anticonvulsants
  Calcium Channel Modifying Agents
   Ethosuximide
    D00539  Ethosuximide (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D00539  Ethosuximide (JP18/USP/INN)
Drug groups [BR:br08330]
Cardiovascular agent
  DG01575  Calcium channel blocker
   DG01573  Calcium channel T type blocker
    D00539  Ethosuximide
Neuropsychiatric agent
  DG03199  Antiepileptic agent
   DG02033  Succinimide antiepileptic
    D00539  Ethosuximide
Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D00539  Ethosuximide
Drug classes [BR:br08332]
Neuropsychiatric agent
  DG03199  Antiepileptic agent
   D00539  Ethosuximide
Target-based classification of drugs [BR:br08310]
Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA1-T
     D00539  Ethosuximide (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00539  Ethosuximide
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00539

Other DBs

CAS:

77-67-8

PubChem:

7847605

ChEBI:

4887

LigandBox:

D00539

NIKKAJI:

J1.477J

KCF data

ATOM        10
            1   C1z C    30.2572  -15.7833
            2   C5x C    31.0718  -14.6371
            3   C1x C    28.9189  -15.3703
            4   C1b C    31.5607  -16.2779
            5   C1a C    29.4311  -16.9121
            6   N1x N    30.2341  -13.5199
            7   O5x O    32.4683  -14.6255
            8   C5x C    28.9016  -13.9681
            9   C1a C    31.5774  -17.6569
            10  O5x O    27.7611  -13.1534
BOND        10
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 1
            6     2   7 2
            7     3   8 1
            8     4   9 1
            9     8  10 2
            10    6   8 1