Entry

D00559                      Drug

Name

Pramipexole dihydrochloride (USP);
Pramipexole hydrochloride hydrate (JAN);
Pramipexole dihydrochloride monohydrate;
Mirapex (TN)

Product

MIRAPEX (Boehringer Ingelheim Pharmaceuticals)

Generic

PRAMIPEXOLE (Camber Pharmaceuticals), PRAMIPEXOLE DIHYDROCHLORIDE (Par Pharmaceutical), PRAMIPEXOLE DIHYDROCHLORIDE (A-S Medication Solutions), PRAMIPEXOLE DIHYDROCHLORIDE (A-S Medication Solutions), PRAMIPEXOLE DIHYDROCHLORIDE (A-S Medication Solutions), PRAMIPEXOLE DIHYDROCHLORIDE (A-S Medication Solutions), PRAMIPEXOLE DIHYDROCHLORIDE (Alembic Pharmaceuticals), PRAMIPEXOLE DIHYDROCHLORIDE (Alembic Pharmaceuticals), PRAMIPEXOLE DIHYDROCHLORIDE (Alembic Pharmaceuticals Limited), PRAMIPEXOLE DIHYDROCHLORIDE (Alembic Pharmaceuticals Limited), PRAMIPEXOLE DIHYDROCHLORIDE (Alembic Pharmaceuticals Limited), PRAMIPEXOLE DIHYDROCHLORIDE (American Health Packaging), PRAMIPEXOLE DIHYDROCHLORIDE (Aurobindo Pharma Limited), PRAMIPEXOLE DIHYDROCHLORIDE (Bryant Ranch Prepack), PRAMIPEXOLE DIHYDROCHLORIDE (Bryant Ranch Prepack), PRAMIPEXOLE DIHYDROCHLORIDE (Bryant Ranch Prepack), PRAMIPEXOLE DIHYDROCHLORIDE (Bryant Ranch Prepack), PRAMIPEXOLE DIHYDROCHLORIDE (Bryant Ranch Prepack), PRAMIPEXOLE DIHYDROCHLORIDE (Bryant Ranch Prepack), PRAMIPEXOLE DIHYDROCHLORIDE (Bryant Ranch Prepack), PRAMIPEXOLE DIHYDROCHLORIDE (Bryant Ranch Prepack), PRAMIPEXOLE DIHYDROCHLORIDE (Bryant Ranch Prepack), PRAMIPEXOLE DIHYDROCHLORIDE (Cadila Healthcare Limited), PRAMIPEXOLE DIHYDROCHLORIDE (Cadila Healthcare Limited), PRAMIPEXOLE DIHYDROCHLORIDE (Dr. Reddy's Laboratories Limited), PRAMIPEXOLE DIHYDROCHLORIDE (Glenmark Pharmaceuticals), PRAMIPEXOLE DIHYDROCHLORIDE (Golden State Medical Supply), PRAMIPEXOLE DIHYDROCHLORIDE (Ingenus Pharmaceuticals), PRAMIPEXOLE DIHYDROCHLORIDE (Macleods Pharmaceuticals Limited), PRAMIPEXOLE DIHYDROCHLORIDE (Major Pharmaceuticals), PRAMIPEXOLE DIHYDROCHLORIDE (NorthStar RxLLC), PRAMIPEXOLE DIHYDROCHLORIDE (Rising Health), PRAMIPEXOLE DIHYDROCHLORIDE (ScieGen Pharmaceuticals), PRAMIPEXOLE DIHYDROCHLORIDE (Strides Pharma Science Limited), PRAMIPEXOLE DIHYDROCHLORIDE (Torrent Pharmaceuticals Limited), PRAMIPEXOLE DIHYDROCHLORIDE (Unichem Pharmaceuticals (USA)), PRAMIPEXOLE DIHYDROCHLORIDE (Vitruvias Therapeutics), PRAMIPEXOLE DIHYDROCHLORIDE (Xiamen LP Pharmaceutical), PRAMIPEXOLE DIHYDROCHLORIDE (Zydus Pharmaceuticals (USA)), PRAMIPEXOLE DIHYDROCHLORIDE (Zydus Pharmaceuticals (USA))

Formula

C10H17N3S. 2HCl. H2O

Exact mass

301.0782

Mol weight

302.2642

Structure

Simcomp

Class

Neuropsychiatric agent
DG01472 Dopamine agonist
DG01967 Antiparkinson agent

Remark

Therapeutic category:

1169 1190

ATC code:

N04BC05

Chemical structure group:

DG00863

Product (DG00863):

D00559<JP/US>

Efficacy

Antidepressant, Antiparkinsonian, Dopamine receptor agonist

Disease

Parkinson disease [DS:H00057]
Restless legs syndrome [DS:H01597]

Target

DRD2 [HSA:1813] [KO:K04145]
DRD3 [HSA:1814] [KO:K04146]
DRD4 [HSA:1815] [KO:K04147]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04728

Dopaminergic synapse

hsa05012

Parkinson disease

Interaction

Structure map

map07057

Antiparkinsonian agents

map07213

Dopamine receptor agonists/antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04B DOPAMINERGIC AGENTS
    N04BC Dopamine agonists
     N04BC05 Pramipexole
      D00559  Pramipexole dihydrochloride (USP) <JP/US>
USP drug classification [BR:br08302]
Antiparkinson Agents
  Dopamine Agonists
   Pramipexole
    D00559  Pramipexole dihydrochloride (USP)
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   116  Antiparkinsonian agents
    1169  Others
     D00559  Pramipexole dihydrochloride (USP); Pramipexole hydrochloride hydrate (JAN)
   119  Miscellaneous
    1190  Miscellaneous
     D00559  Pramipexole dihydrochloride (USP); Pramipexole hydrochloride hydrate (JAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01472  Dopamine agonist
   DG00863  Pramipexole
    D00559  Pramipexole dihydrochloride
  DG01967  Antiparkinson agent
   DG00863  Pramipexole
    D00559  Pramipexole dihydrochloride
Drug classes [BR:br08332]
Neuropsychiatric agent
  DG01967  Antiparkinson agent
   D00559  Pramipexole dihydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D00559  Pramipexole dihydrochloride (USP) <JP/US>
    DRD3
     D00559  Pramipexole dihydrochloride (USP) <JP/US>
    DRD4
     D00559  Pramipexole dihydrochloride (USP) <JP/US>
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D00559
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D00559
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01472  Dopamine agonist
   DG00863  Pramipexole
  DG01967  Antiparkinson agent
   DG00863  Pramipexole

Other DBs

CAS:	191217-81-9

PubChem:

7847625

ChEBI:

51147 8356

LigandBox:

D00559

NIKKAJI:

J1.992.469F

KCF data

ATOM        17
            1   C8y C    21.1335  -18.9431
            2   C8y C    21.1744  -17.5455
            3   N5x N    22.5777  -19.3681
            4   C1x C    20.0330  -19.6475
            5   C1x C    20.0274  -16.8467
            6   S2x S    22.5720  -17.1086
            7   C8y C    23.3987  -18.2384
            8   C1x C    18.8276  -18.9548
            9   C1y C    18.8219  -17.5513
            10  N1a N    24.8023  -18.2793
            11  N1b N    17.6048  -16.8524
            12  C1b C    16.3936  -17.5572
            13  C1b C    15.1884  -16.8583
            14  C1a C    13.9771  -17.5629
            15  X   Cl   29.1282  -17.3329
            16  O0  O    29.1804  -19.7534
            17  X   Cl   29.1282  -17.3329
BOND        15
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     7  10 1
            10    9  11 1 #Down
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14    6   7 1
            15    8   9 1
BRACKET     1    27.5100  -18.2000   27.5100  -16.5200
            1    30.0300  -16.5200   30.0300  -18.2000
            1  2
ORIGINAL  1   15
REPEAT    1   17