Entry

D00578                      Drug

Name

Voriconazole (JP18/USP/INN);
Vfend (TN)

Abbr

VRC

Product

VFEND (Roerig), VFEND (Roerig), VFEND (Roerig), VFEND (Roerig), VORICONAZOLE (XGen Pharmaceuticals DJB)

Generic

VORICONAZOLE (Ajanta Pharma USA), VORICONAZOLE (Alvogen), VORICONAZOLE (American Health Packaging), VORICONAZOLE (Amneal Pharmaceuticals LLC), VORICONAZOLE (Aurobindo Pharma Limited), VORICONAZOLE (AvPAK), VORICONAZOLE (Bryant Ranch Prepack), VORICONAZOLE (Cadila Healthcare Limited), VORICONAZOLE (Cadila Healthcare Limited), VORICONAZOLE (Fosun Pharma USA), VORICONAZOLE (Fresenius Kabi USA), VORICONAZOLE (Gland Pharma Limited), VORICONAZOLE (Glenmark Pharmaceuticals), VORICONAZOLE (Golden State Medical Supply), VORICONAZOLE (Greenstone LLC), VORICONAZOLE (Lupin Pharmaceuticals), VORICONAZOLE (Lupin Pharmaceuticals), VORICONAZOLE (Major Pharmaceuticals), VORICONAZOLE (Major Pharmaceuticals), VORICONAZOLE (Mckesson Corporation DBA SKY Packaginng), VORICONAZOLE (Meitheal Pharmaceuticals), VORICONAZOLE (Mylan Institutional), VORICONAZOLE (Mylan Pharmaceuticals), VORICONAZOLE (NorthStar Rx LLC), VORICONAZOLE (Novel Laboratories), VORICONAZOLE (Novel Laboratories), VORICONAZOLE (Rising Pharmaceuticals), VORICONAZOLE (Sandoz), VORICONAZOLE (Sandoz), VORICONAZOLE (Slate Run Pharmaceuticals), VORICONAZOLE (Solco Healthcare U.S.), VORICONAZOLE (Viona Pharmaceuticals), VORICONAZOLE (Zydus Pharmaceuticals (USA))

Formula

C16H14F3N5O

Exact mass

349.115

Mol weight

349.3105

Structure

Simcomp

Class

Antifungal
DG01523 Triazole antifungal
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor

Remark

Same as:

C07622

Therapeutic category:

6179

ATC code:

J02AC03

Product:

D00578<JP/US>

Efficacy

Antifungal, Ergosterol biosynthesis inhibitor

Disease

Invasive aspergillosis [DS:H01328]
Esophageal candidiasis [DS:H00363]
Scedosporiosis [DS:H02392]

Target

sterol 14alpha-demethylase [KO:K05917]

Pathway

ko00100

Steroid biosynthesis

Interaction

CYP inhibition: CYP3A [HSA:1576 1577 1551]

Structure map

map07026

Antifungal agents

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
  J02 ANTIMYCOTICS FOR SYSTEMIC USE
   J02A ANTIMYCOTICS FOR SYSTEMIC USE
    J02AC Triazole and tetrazole derivatives
     J02AC03 Voriconazole
      D00578  Voriconazole (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antifungals
  Voriconazole
   D00578  Voriconazole (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
6  Agents against pathologic organisms and parasites
  61  Antibiotics
   617  Acting mainly on mold
    6179  Others
     D00578  Voriconazole (JP18/USP/INN)
Drug groups [BR:br08330]
Antifungal
  DG01523  Triazole antifungal
   D00578  Voriconazole
Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   D00578  Voriconazole
Drug classes [BR:br08332]
Antifungal
  DG01523  Triazole antifungal
   D00578  Voriconazole
Antimicrobials [BR:br08307]
Antifungals
  Ergosterol biosynthesis inhibitor
   Triazole
    D00578  Voriconazole (JP18/USP/INN) <JP/US>
Antimicrobials abbreviations [BR:br08327]
Antifungals
  Ergosterol biosynthesis inhibitor
   Triazole
    D00578  Voriconazole (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00578  Voriconazole
  D00578  Voriconazole tablets
  D00578  Voriconazole for injection
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D00578
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D00578
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D00578
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D00578
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00578
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
  D00578

Other DBs

CAS:	137234-62-9

PubChem:

7847644

ChEBI:

10023

PDB-CCD:

VOR[PDBj]

LigandBox:

D00578

NIKKAJI:

J709.476K

KCF data

ATOM        25
            1   C1d C    25.0014  -20.8416
            2   C8y C    25.0014  -18.5274
            3   C1c C    23.8241  -21.5118
            4   C1b C    26.1673  -21.5178
            5   O1a O    25.0014  -22.1939
            6   C8y C    26.1614  -17.8513
            7   C8x C    23.8241  -17.8513
            8   C8y C    22.6232  -20.8240
            9   C1a C    23.8181  -22.8992
            10  N4y N    27.3447  -20.8357
            11  C8x C    26.1614  -16.5049
            12  X   F    27.3389  -18.5274
            13  C8x C    23.8241  -16.5049
            14  C8y C    21.4225  -21.5118
            15  N5x N    22.6349  -19.4367
            16  C8x C    27.4030  -19.4950
            17  N5x N    28.5688  -21.3895
            18  C8y C    25.0014  -15.8228
            19  C8x C    20.2216  -20.8183
            20  X   F    21.4225  -22.8992
            21  C8x C    21.4283  -18.7374
            22  N5x N    28.7960  -19.2095
            23  C8x C    29.4839  -20.3869
            24  X   F    25.0014  -14.4647
            25  N5x N    20.2216  -19.4310
BOND        27
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Down
            5     2   6 2
            6     2   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    6  11 1
            11    6  12 1
            12    7  13 2
            13    8  14 1
            14    8  15 2
            15   10  16 1
            16   10  17 1
            17   11  18 2
            18   14  19 2
            19   14  20 1
            20   15  21 1
            21   16  22 2
            22   17  23 2
            23   18  24 1
            24   19  25 1
            25   13  18 1
            26   21  25 2
            27   22  23 1