Levofloxacin


Entry
D00588                      Drug                                   
Name
Levofloxacin (USP);
Levofloxacin hydrate (JP18);
Levofloxacin hemihydrate;
Iquix (TN);
Levaquin (TN);
Quixin (TN)
Product
  Generic
LEVOFLOXACIN (A-S Medication Solutions), LEVOFLOXACIN (A-S Medication Solutions), LEVOFLOXACIN (A-S Medication Solutions), LEVOFLOXACIN (A-S Medication Solutions), LEVOFLOXACIN (A-S Medication Solutions), LEVOFLOXACIN (A-S Medication Solutions), LEVOFLOXACIN (A-S Medication Solutions), LEVOFLOXACIN (A-S Medication Solutions), LEVOFLOXACIN (ACETRIS HEALTH), LEVOFLOXACIN (ADVANCED RX PHARMACY OF TENNESSEE), LEVOFLOXACIN (Advanced Rx Pharmacy of Tennessee), LEVOFLOXACIN (Advanced Rx Pharmacy of Tennessee), LEVOFLOXACIN (Advanced Rx Pharmacy of Tennessee), LEVOFLOXACIN (Advanced Rx Pharmacy of Tennessee), LEVOFLOXACIN (Akorn), LEVOFLOXACIN (Akorn), LEVOFLOXACIN (Akorn), LEVOFLOXACIN (AuroMedics Pharma LLC), LEVOFLOXACIN (Aurobindo Pharma Limited), LEVOFLOXACIN (BPI LABS LLC), LEVOFLOXACIN (Baxter Healthcare Corporation), LEVOFLOXACIN (Baxter Healthcare Corporation), LEVOFLOXACIN (Bryant Ranch Prepack), LEVOFLOXACIN (Bryant Ranch Prepack), LEVOFLOXACIN (Bryant Ranch Prepack), LEVOFLOXACIN (Bryant Ranch Prepack), LEVOFLOXACIN (Bryant Ranch Prepack), LEVOFLOXACIN (Bryant Ranch Prepack), LEVOFLOXACIN (Bryant Ranch Prepack), LEVOFLOXACIN (Bryant Ranch Prepack), LEVOFLOXACIN (Bryant Ranch Prepack), LEVOFLOXACIN (Bryant Ranch Prepack), LEVOFLOXACIN (Bryant Ranch Prepack), LEVOFLOXACIN (Bryant Ranch Prepack), LEVOFLOXACIN (Cadila Healthcare Limited), LEVOFLOXACIN (Cadila Healthcare Limited), LEVOFLOXACIN (Camber Pharmaceuticals), LEVOFLOXACIN (Cardinal Health), LEVOFLOXACIN (Cipla USA), LEVOFLOXACIN (Clinical Solutions Wholesale), LEVOFLOXACIN (DIRECT RX), LEVOFLOXACIN (DIRECT RX), LEVOFLOXACIN (Denton Pharma), LEVOFLOXACIN (Denton Pharma), LEVOFLOXACIN (Denton Pharma), LEVOFLOXACIN (DirectRx), LEVOFLOXACIN (Direct_Rx), LEVOFLOXACIN (Direct_Rx), LEVOFLOXACIN (Dr. Reddy's Laboratories Limited), LEVOFLOXACIN (Fresenius Kabi USA), LEVOFLOXACIN (Gland Pharma Limited), LEVOFLOXACIN (Gland Pharma Limited), LEVOFLOXACIN (Golden State Medical Supply), LEVOFLOXACIN (Hikma Pharmaceuticals USA), LEVOFLOXACIN (Hikma Pharmaceuticals USA), LEVOFLOXACIN (Hospira), LEVOFLOXACIN (Lannett Company), LEVOFLOXACIN (Lupin Pharmaceuticals), LEVOFLOXACIN (Macleods Pharmaceuticals Limited), LEVOFLOXACIN (Major Pharmaceuticals), LEVOFLOXACIN (Medsource Pharmaceuticals), LEVOFLOXACIN (Micro Labs Limited), LEVOFLOXACIN (NuCare Pharmaceuticals), LEVOFLOXACIN (NuCare Pharmaceuticals), LEVOFLOXACIN (NuCare Pharmaceuticals), LEVOFLOXACIN (NuCare Pharmaceuticals), LEVOFLOXACIN (NuCare Pharmaceuticals), LEVOFLOXACIN (NuCare Pharmaceuticals), LEVOFLOXACIN (NuCare Pharmaceuticals), LEVOFLOXACIN (NuCare Pharmaceuticals), LEVOFLOXACIN (NuCare Pharmaceuticals), LEVOFLOXACIN (NuCare Pharmaceuticals), LEVOFLOXACIN (NuCare Pharmaceuticals), LEVOFLOXACIN (NuCare Pharmaceuticals), LEVOFLOXACIN (NuCarePharmaceuticals), LEVOFLOXACIN (PD-Rx Pharmaceuticals), LEVOFLOXACIN (PD-Rx Pharmaceuticals), LEVOFLOXACIN (PD-Rx Pharmaceuticals), LEVOFLOXACIN (PD-Rx Pharmaceuticals), LEVOFLOXACIN (PD-Rx Pharmaceuticals), LEVOFLOXACIN (PD-Rx Pharmaceuticals), LEVOFLOXACIN (PD-Rx Pharmaceuticals), LEVOFLOXACIN (PharmPak), LEVOFLOXACIN (Preferred Pharmaceuticals), LEVOFLOXACIN (Proficient Rx), LEVOFLOXACIN (Proficient Rx LP), LEVOFLOXACIN (Proficient Rx LP), LEVOFLOXACIN (Proficient Rx LP), LEVOFLOXACIN (Proficient Rx LP), LEVOFLOXACIN (Proficient Rx LP), LEVOFLOXACIN (Proficient Rx LP), LEVOFLOXACIN (Proficient Rx LP), LEVOFLOXACIN (Proficient Rx LP), LEVOFLOXACIN (QPharma), LEVOFLOXACIN (Quality Care Products), LEVOFLOXACIN (REMEDYREPACK), LEVOFLOXACIN (REMEDYREPACK), LEVOFLOXACIN (REMEDYREPACK), LEVOFLOXACIN (REMEDYREPACK), LEVOFLOXACIN (REMEDYREPACK), LEVOFLOXACIN (REMEDYREPACK), LEVOFLOXACIN (REMEDYREPACK), LEVOFLOXACIN (RPK Pharmaceuticals), LEVOFLOXACIN (RPK Pharmaceuticals), LEVOFLOXACIN (RPK Pharmaceuticals), LEVOFLOXACIN (RPK Pharmaceuticals), LEVOFLOXACIN (RPK Pharmaceuticals), LEVOFLOXACIN (RedPharm Drug), LEVOFLOXACIN (RedPharm Drug), LEVOFLOXACIN (RedPharm Drug), LEVOFLOXACIN (RedPharm Drug), LEVOFLOXACIN (RedPharm Drug), LEVOFLOXACIN (RedPharm Drug), LEVOFLOXACIN (RedPharm Drug), LEVOFLOXACIN (RedPharm Drug), LEVOFLOXACIN (RedPharm Drug), LEVOFLOXACIN (RedPharm Drug), LEVOFLOXACIN (RedPharm Drug), LEVOFLOXACIN (RedPharm Drug), LEVOFLOXACIN (RedPharm Drug), LEVOFLOXACIN (RedPharm Drug), LEVOFLOXACIN (Sagent Pharmaceuticals), LEVOFLOXACIN (Sandoz), LEVOFLOXACIN (Torrent Pharmaceuticals Limited), LEVOFLOXACIN (Viona Pharmaceuticals), LEVOFLOXACIN (WG Critical Care), LEVOFLOXACIN (Zydus Pharmaceuticals (USA)), LEVOFLOXACIN (AuroMedics Pharma LLC)
Formula
(C18H20FN3O4)2. H2O
Exact mass
740.2981
Mol weight
740.7503
Structure
Simcomp
Class
Antibacterial
 DG01550  Quinolone
  DG01549  Fluoroquinolone
 DG01966  Antitubercular
Transporter substrate
 DG02857  SLCO1A2 substrate
Remark
Therapeutic category: 1319 6241
ATC code: J01MA12 S01AE05
Chemical structure group: DG00624
Product (DG00624): D00588<JP/US>
Efficacy
Antibacterial, Nucleic acid biosynthesis inhibitor
  Disease
Inhalational anthrax [DS:H00328]
Plague [DS:H00297]
Uncomplicated urinary tract infections [DS:H01176]
Target
DNA gyrase [KO:K02469 K02470]
topoisomerase IV [KO:K02621 K02622]
Metabolism
Transporter: SLCO1A2 [HSA:6579]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA12 Levofloxacin
      D00588  Levofloxacin (USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AE Fluoroquinolones
     S01AE05 Levofloxacin
      D00588  Levofloxacin (USP) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Quinolones
   Levofloxacin
    D00588  Levofloxacin (USP)
 Ophthalmic Agents
  Ophthalmic Anti-Infectives
   Antibacterials, Ophthalmic
    Levofloxacin
     D00588  Levofloxacin (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00588  Levofloxacin (USP); Levofloxacin hydrate (JP18)
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   624  Synthetic antibacterials
    6241  Pyridonecarboxylic acids
     D00588  Levofloxacin (USP); Levofloxacin hydrate (JP18)
Drug groups [BR:br08330]
 Antibacterial
  DG01550  Quinolone
   DG01549  Fluoroquinolone
    DG00624  Levofloxacin
     D00588  Levofloxacin
  DG01966  Antitubercular
   DG00624  Levofloxacin
    D00588  Levofloxacin
 Transporter substrate
  DG02857  SLCO1A2 substrate
   DG00624  Levofloxacin
    D00588  Levofloxacin
Drug classes [BR:br08332]
 Antibacterial
  DG01549  Fluoroquinolone
   D00588  Levofloxacin
Antimicrobials [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   Fluoroquinolone
    D00588  Levofloxacin (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00588  Levofloxacin hydrate
  D00588  Levofloxacin tablets
  D00588  Levofloxacin fine granules
  D00588  Levofloxacin injection
  D00588  Levofloxacin ophthalmic solution
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00588
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D00588
Drug groups [BR:br08330]
 Antibacterial
  DG01550  Quinolone
   DG01549  Fluoroquinolone
    DG00624  Levofloxacin
  DG01966  Antitubercular
   DG00624  Levofloxacin
 Transporter substrate
  DG02857  SLCO1A2 substrate
   DG00624  Levofloxacin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Nucleic acid synthesis inhibitor
   Fluoroquinolone
    DG00624  Levofloxacin
Other DBs
CAS: 138199-71-0
PubChem: 7847654
LigandBox: D00588
KCF data

ATOM        53
            1   C8y C    25.5128  -19.2413
            2   C8y C    24.2948  -19.9406
            3   C8y C    25.5070  -17.8485
            4   N4y N    26.7249  -19.9406
            5   C8y C    23.0828  -19.2354
            6   O2x O    24.2948  -21.3449
            7   C8y C    26.7133  -17.1434
            8   C8x C    24.3007  -17.1318
            9   C8x C    27.9312  -19.2354
            10  C1y C    26.7249  -21.3449
            11  N1y N    21.8590  -19.9406
            12  C8y C    23.0828  -17.8311
            13  C1x C    25.5128  -22.0383
            14  C8y C    27.9312  -17.8368
            15  O5x O    26.7074  -15.7506
            16  C1a C    27.9312  -22.0442
            17  C1x C    21.8532  -21.3449
            18  C1x C    20.6470  -19.2296
            19  X   F    21.8590  -17.1434
            20  C6a C    29.1316  -17.1434
            21  C1x C    20.6353  -22.0325
            22  C1x C    19.4407  -19.9289
            23  O6a O    30.3378  -17.8427
            24  O6a O    29.1258  -15.7448
            25  N1y N    19.4290  -21.3333
            26  C1a C    18.2111  -22.0325
            27  O0  O    34.9829  -18.9205
            28  C8y C    25.5128  -19.2413
            29  C8y C    24.2948  -19.9406
            30  C8y C    23.0828  -19.2354
            31  N1y N    21.8590  -19.9406
            32  C1x C    21.8532  -21.3449
            33  C1x C    20.6353  -22.0325
            34  N1y N    19.4290  -21.3333
            35  C1a C    18.2111  -22.0325
            36  C1x C    19.4407  -19.9289
            37  C1x C    20.6470  -19.2296
            38  C8y C    23.0828  -17.8311
            39  C8x C    24.3007  -17.1318
            40  C8y C    25.5070  -17.8485
            41  C8y C    26.7133  -17.1434
            42  C8y C    27.9312  -17.8368
            43  C8x C    27.9312  -19.2354
            44  N4y N    26.7249  -19.9406
            45  C1y C    26.7249  -21.3449
            46  C1x C    25.5128  -22.0383
            47  O2x O    24.2948  -21.3449
            48  C1a C    27.9312  -22.0442
            49  C6a C    29.1316  -17.1434
            50  O6a O    30.3378  -17.8427
            51  O6a O    29.1258  -15.7448
            52  O5x O    26.7074  -15.7506
            53  X   F    21.8590  -17.1434
BOND        58
            1    25  26 1
            2     8  12 2
            3     9  14 2
            4    10  13 1
            5    22  25 1
            6     1   2 1
            7     1   3 2
            8     1   4 1
            9     2   5 2
            10    2   6 1
            11    3   7 1
            12    3   8 1
            13    4   9 1
            14    4  10 1
            15    5  11 1
            16    5  12 1
            17    6  13 1
            18    7  14 1
            19    7  15 2
            20   10  16 1 #Up
            21   11  17 1
            22   11  18 1
            23   12  19 1
            24   14  20 1
            25   17  21 1
            26   18  22 1
            27   20  23 1
            28   20  24 2
            29   21  25 1
            30   34  35 1
            31   39  38 2
            32   43  42 2
            33   45  46 1
            34   36  34 1
            35   28  29 1
            36   28  40 2
            37   28  44 1
            38   29  30 2
            39   29  47 1
            40   40  41 1
            41   40  39 1
            42   44  43 1
            43   44  45 1
            44   30  31 1
            45   30  38 1
            46   47  46 1
            47   41  42 1
            48   41  52 2
            49   45  48 1 #Up
            50   31  32 1
            51   31  37 1
            52   38  53 1
            53   42  49 1
            54   32  33 1
            55   37  36 1
            56   49  50 1
            57   49  51 2
            58   33  34 1
BRACKET     1    16.7300  -23.0300   16.7300  -15.1200
            1    31.5700  -15.1200   31.5700  -23.0300
            1  2
 ORIGINAL  1    1   2   5  11  17  21  25  26  22  18  12   8   3   7  14   9
            1    4  10  13   6  16  20  23  24  15  19
 REPEAT    1   28  29  30  31  32  33  34  35  36  37  38  39  40  41  42  43
            1   44  45  46  47  48  49  50  51  52  53