| Entry |
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|---|---|---|---|---|---|---|---|---|---|---|---|
| Name | Acebutolol hydrochloride (JP18/USP); Sectral (TN) | ||||||||||
| Product | |||||||||||
| Generic | ACEBUTOLOL HYDROCHLORIDE (ANI Pharmaceuticals), ACEBUTOLOL HYDROCHLORIDE (Amneal Pharmaceuticals LLC), ACEBUTOLOL HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), ACEBUTOLOL HYDROCHLORIDE (AvPAK), ACEBUTOLOL HYDROCHLORIDE (Marlex Pharmaceuticals) | ||||||||||
| Formula | C18H28N2O4. HCl | ||||||||||
| Exact mass | 372.1816 | ||||||||||
| Mol weight | 372.8869 | ||||||||||
| Structure |  | ||||||||||
| Simcomp | |||||||||||
| Class | Cardiovascular agent DG01466 Adrenergic receptor antagonist DG01464 beta-Adrenergic receptor antagonist (Beta blocker) DG01461 beta1-Adrenergic receptor antagonist DG01653 Antiarrhythmics DG01806 Class II antiarrhythmic agent | ||||||||||
| Remark |
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| Efficacy | Antiarrhythmic, Antihypertensive, Vasodilator, beta1-Adrenergic receptor antagonist | ||||||||||
| Disease | Hypertension [DS:H01633] | ||||||||||
| Comment | Propranolol derivative | ||||||||||
| Target | ADRB1 [HSA:153] [KO:K04141] | ||||||||||
| Pathway |
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| Interaction | |||||||||||
| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] C CARDIOVASCULAR SYSTEM C07 BETA BLOCKING AGENTS C07A BETA BLOCKING AGENTS C07AB Beta blocking agents, selective C07AB04 Acebutolol D00597 Acebutolol hydrochloride (JP18/USP) <US> USP drug classification [BR:br08302] Cardiovascular Agents Antiarrhythmics Vaughn Williams-Class II Acebutolol D00597 Acebutolol hydrochloride (JP18/USP) Beta-adrenergic Blocking Agents Beta-adrenergic Blocking Agents, Other Acebutolol D00597 Acebutolol hydrochloride (JP18/USP) Therapeutic category of drugs in Japan [BR:br08301] 2 Agents affecting individual organs 21 Cardiovascular agents 212 Antiarrhythmic agents 2123 Beta blockers D00597 Acebutolol hydrochloride (JP18/USP) Drug groups [BR:br08330] Cardiovascular agent DG01466 Adrenergic receptor antagonist DG01464 beta-Adrenergic receptor antagonist (Beta blocker) DG01461 beta1-Adrenergic receptor antagonist DG00314 Acebutolol D00597 Acebutolol hydrochloride DG01653 Antiarrhythmics DG01806 Class II antiarrhythmic agent DG00314 Acebutolol D00597 Acebutolol hydrochloride Drug classes [BR:br08332] Cardiovascular agent DG01653 Antiarrhythmics D00597 Acebutolol hydrochloride Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Rhodopsin family Adrenaline ADRB1 D00597 Acebutolol hydrochloride (JP18/USP) <US> Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D00597 Acebutolol hydrochloride Drug groups [BR:br08330] Cardiovascular agent DG01466 Adrenergic receptor antagonist DG01464 beta-Adrenergic receptor antagonist (Beta blocker) DG01461 beta1-Adrenergic receptor antagonist DG00314 Acebutolol DG01653 Antiarrhythmics DG01806 Class II antiarrhythmic agent DG00314 Acebutolol | ||||||||||
| Other DBs |
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| KCF data | ATOM 25 1 C8y C 21.9841 -14.0731 2 C8y C 20.7938 -14.7732 3 C8x C 23.2443 -14.7732 4 O2a O 21.9841 -12.6728 5 C8x C 20.7938 -16.1735 6 C5a C 19.5336 -14.0731 7 C8x C 23.2443 -16.1035 8 C1b C 23.1743 -11.9727 9 C8y C 22.0541 -16.8737 10 C1a C 18.3433 -14.7732 11 O5a O 19.5336 -12.6728 12 C1c C 24.3646 -12.6028 13 N1b N 22.0541 -18.2740 14 C1b C 25.6248 -11.9026 15 O1a O 24.3646 -14.0031 16 C5a C 20.8638 -18.9741 17 N1b N 26.8151 -12.6028 18 C1b C 19.6036 -18.2740 19 O5a O 20.8638 -20.3744 20 C1c C 28.0053 -11.9026 21 C1b C 18.4133 -19.0441 22 C1a C 29.2656 -12.5328 23 C1a C 28.0053 -10.5024 24 C1a C 17.2231 -18.3440 25 X Cl 31.9262 -16.3136 BOND 24 1 1 2 1 2 1 3 2 3 1 4 1 4 2 5 2 5 2 6 1 6 3 7 1 7 4 8 1 8 5 9 1 9 6 10 1 10 6 11 2 11 8 12 1 12 9 13 1 13 12 14 1 14 12 15 1 15 13 16 1 16 14 17 1 17 16 18 1 18 16 19 2 19 17 20 1 20 18 21 1 21 20 22 1 22 20 23 1 23 21 24 1 24 7 9 2 |