Entry

D00620                      Drug

Name

Benazepril hydrochloride (JAN/USP);
Lotensin (TN)

Product

LOTENSIN (Validus Pharmaceuticals LLC)

Generic

BENAZEPRIL (Direct_Rx), BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions), BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions), BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions), BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions), BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions), BENAZEPRIL HYDROCHLORIDE (A-S Medication Solutions), BENAZEPRIL HYDROCHLORIDE (Amneal Pharmaceuticals LLC), BENAZEPRIL HYDROCHLORIDE (Aurobindo Pharma Limited), BENAZEPRIL HYDROCHLORIDE (AvKARE), BENAZEPRIL HYDROCHLORIDE (AvPAK), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Bryant Ranch Prepack), BENAZEPRIL HYDROCHLORIDE (Cadila Healthcare Limited), BENAZEPRIL HYDROCHLORIDE (Cardinal Health), BENAZEPRIL HYDROCHLORIDE (DIRECT RX), BENAZEPRIL HYDROCHLORIDE (DIRECT RX), BENAZEPRIL HYDROCHLORIDE (Denton Pharma), BENAZEPRIL HYDROCHLORIDE (Denton Pharma), BENAZEPRIL HYDROCHLORIDE (Denton Pharma), BENAZEPRIL HYDROCHLORIDE (Denton Pharma), BENAZEPRIL HYDROCHLORIDE (Denton Pharma), BENAZEPRIL HYDROCHLORIDE (Denton Pharma), BENAZEPRIL HYDROCHLORIDE (Denton Pharma), BENAZEPRIL HYDROCHLORIDE (Golden State Medical Supply), BENAZEPRIL HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (International Laboratories), BENAZEPRIL HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (NuCare Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (PD-Rx Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Preferred Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Preferred Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Preferred Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Preferred Pharmaceuticlas), BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP), BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP), BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP), BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP), BENAZEPRIL HYDROCHLORIDE (Proficient Rx LP), BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK), BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK), BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK), BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK), BENAZEPRIL HYDROCHLORIDE (REMEDYREPACK), BENAZEPRIL HYDROCHLORIDE (RPK Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (RPK Pharmaceuticals), BENAZEPRIL HYDROCHLORIDE (Solco healthcare U.S.), BENAZEPRIL HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), BENAZEPRIL HYDROCHLORIDE (St. Mary's Medical Park Pharmacy)

Formula

C24H28N2O5. HCl

Exact mass

460.1765

Mol weight

460.9505

Structure

Simcomp

Class

Cardiovascular agent
DG01925  Renin-angiotensin system inhibitor
  DG01501  Angiotensin-converting enzyme inhibitor
DG03231  Antihypertensive
  DG01501  Angiotensin-converting enzyme inhibitor
Metabolizing enzyme substrate
DG02924  UGT substrate

Remark

Same as:

C07701

Therapeutic category:

2144

ATC code:

C09AA07

Chemical structure group:

DG00339

Product (DG00339):

D00620<JP/US>

Product (mixture):

D10279<US> D11069<US>

Efficacy

Antihypertensive, Angiotensin-converting enzyme inhibitor

Disease

Hypertension [DS:H01633]

Comment

Active form of prodrug: Benazeprilat [DR:D03077]

Target

ACE (CD143) [HSA:1636] [KO:K01283]

Pathway

hsa04614

Renin-angiotensin system

Metabolism

Enzyme: UGT [KO:K00699]

Interaction

Structure map

map07217

Renin-angiotensin system inhibitors

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09A ACE INHIBITORS, PLAIN
    C09AA ACE inhibitors, plain
     C09AA07 Benazepril
      D00620  Benazepril hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
  Angiotensin-converting Enzyme (ACE) Inhibitors
   Benazepril
    D00620  Benazepril hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  21  Cardiovascular agents
   214  Antihypertensives
    2144  Angiotensin converting enzyme inhibitors
     D00620  Benazepril hydrochloride (JAN/USP)
Drug groups [BR:br08330]
Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00339  Benazepril
     D00620  Benazepril hydrochloride
  DG03231  Antihypertensive
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00339  Benazepril
     D00620  Benazepril hydrochloride
Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG00339  Benazepril
    D00620  Benazepril hydrochloride
Drug classes [BR:br08332]
Cardiovascular agent
  DG01501  Angiotensin-converting enzyme inhibitor
   D00620  Benazepril hydrochloride
  DG03231  Antihypertensive
   D00620  Benazepril hydrochloride
Target-based classification of drugs [BR:br08310]
Enzymes
  Hydrolases (EC3)
   Peptidyl-dipeptidases
    ACE (CD143)
     D00620  Benazepril hydrochloride (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00620
Drug groups [BR:br08330]
Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00339  Benazepril
  DG03231  Antihypertensive
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00339  Benazepril
Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG00339  Benazepril
Prodrugs [br08324.html]
DG00339

Other DBs

CAS:	86541-74-4

PubChem:

7847686

ChEBI:

3012

LigandBox:

D00620

NIKKAJI:

J550.745F

KCF data

ATOM        32
            1   C1x C    23.3231  -19.6615
            2   C8y C    22.4372  -18.5840
            3   C8y C    22.7197  -17.2133
            4   N1y N    23.9591  -16.5857
            5   C1x C    24.7308  -19.7019
            6   C5x C    25.2377  -17.1596
            7   C1y C    25.5777  -18.5180
            8   C8x C    21.6743  -16.2838
            9   C8x C    20.3466  -16.7242
            10  C8x C    20.0641  -18.0949
            11  C8x C    21.1095  -19.0246
            12  C1b C    23.9262  -15.1817
            13  C6a C    25.1248  -14.4519
            14  O6a O    26.3615  -15.1276
            15  O6a O    25.1625  -13.0836
            16  O5x O    26.3330  -16.2423
            17  N1b N    26.9766  -18.5180
            18  C1c C    27.6929  -19.7595
            19  C1b C    29.1069  -19.7602
            20  C7a C    27.0102  -20.9405
            21  C1b C    29.8213  -18.5252
            22  C8y C    31.2056  -18.5264
            23  O6a O    25.6102  -20.9399
            24  O7a O    27.6989  -22.1343
            25  C1b C    29.1070  -22.1349
            26  C1a C    29.7937  -23.3254
            27  C8x C    31.9096  -19.7481
            28  C8x C    33.3085  -19.7492
            29  C8x C    34.0091  -18.5383
            30  C8x C    33.3051  -17.3167
            31  C8x C    31.9062  -17.3155
            32  X   Cl   34.6331  -22.3162
BOND        33
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    4  12 1
            14   12  13 1
            15   13  14 1
            16   13  15 2
            17    6  16 2
            18    7  17 1 #Up
            19   17  18 1
            20   18  19 1 #Up
            21   18  20 1
            22   19  21 1
            23   21  22 1
            24   20  23 2
            25   20  24 1
            26   24  25 1
            27   25  26 1
            28   22  27 2
            29   27  28 1
            30   28  29 2
            31   29  30 1
            32   30  31 2
            33   22  31 1