Fosinopril sodium

Entry

D00622                      Drug

Name

Fosinopril sodium (USP);
Monopril (TN)

Product

Generic

FOSINOPRIL SODIUM (A-S Medication Solutions), FOSINOPRIL SODIUM (AvPAK), FOSINOPRIL SODIUM (Bryant Ranch Prepack), FOSINOPRIL SODIUM (Solco Healthcare LLC), FOSINOPRIL SODIUM (A-S Medication Solutions), FOSINOPRIL SODIUM (Bryant Ranch Prepack), FOSINOPRIL SODIUM (Bryant Ranch Prepack), FOSINOPRIL SODIUM (Bryant Ranch Prepack), FOSINOPRIL SODIUM (Cipla USA), FOSINOPRIL SODIUM (Preferred Pharmaceuticals), FOSINOPRIL SODIUM (A-S Medication Solutions), FOSINOPRIL SODIUM (Aurobindo Pharma Limited), FOSINOPRIL SODIUM (Bryant Ranch Prepack), FOSINOPRIL SODIUM (Bryant Ranch Prepack), FOSINOPRIL SODIUM (Denton Pharma), FOSINOPRIL SODIUM (Exelan Pharmaceuticals), FOSINOPRIL SODIUM (Rising Pharma Holdings)

Formula

C30H45NO7P. Na

Exact mass

585.2831

Mol weight

585.6443

Structure

Simcomp

Class

Cardiovascular agent
DG01925  Renin-angiotensin system inhibitor
  DG01501  Angiotensin-converting enzyme inhibitor
DG03231  Antihypertensive
  DG01501  Angiotensin-converting enzyme inhibitor

Remark

ATC code:

C09AA09

Chemical structure group:

DG00341

Product (DG00341):

D00622<US>

Product (mixture):

D10280<US>

Efficacy

Antihypertensive, Angiotensin-converting enzyme inhibitor

Disease

Hypertension [DS:H01633]

Comment

Active form of prodrug: Fosinoprilat [DR:D03772]

Target

ACE (CD143) [HSA:1636] [KO:K01283]

Pathway

hsa04614

Renin-angiotensin system

Interaction

Structure map

map07217

Renin-angiotensin system inhibitors

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09A ACE INHIBITORS, PLAIN
    C09AA ACE inhibitors, plain
     C09AA09 Fosinopril
      D00622  Fosinopril sodium (USP) <US>
USP drug classification [BR:br08302]
Cardiovascular Agents
  Angiotensin-converting Enzyme (ACE) Inhibitors
   Fosinopril
    D00622  Fosinopril sodium (USP)
Drug groups [BR:br08330]
Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00341  Fosinopril
     D00622  Fosinopril sodium
  DG03231  Antihypertensive
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00341  Fosinopril
     D00622  Fosinopril sodium
Drug classes [BR:br08332]
Cardiovascular agent
  DG01501  Angiotensin-converting enzyme inhibitor
   D00622  Fosinopril sodium
  DG03231  Antihypertensive
   D00622  Fosinopril sodium
Target-based classification of drugs [BR:br08310]
Enzymes
  Hydrolases (EC3)
   Peptidyl-dipeptidases
    ACE (CD143)
     D00622  Fosinopril sodium (USP) <US>
Drug groups [BR:br08330]
Cardiovascular agent
  DG01925  Renin-angiotensin system inhibitor
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00341  Fosinopril
  DG03231  Antihypertensive
   DG01501  Angiotensin-converting enzyme inhibitor
    DG00341  Fosinopril
Prodrugs [br08324.html]
DG00341

Other DBs

CAS:	88889-14-9

PubChem:

7847688

ChEBI:

5164

LigandBox:

D00622

NIKKAJI:

J351.178B

KCF data

ATOM        40
            1   C8x C    10.2582  -15.1697
            2   C8x C    10.2582  -16.5677
            3   C8x C    11.4466  -17.2668
            4   C8x C    12.7048  -16.5677
            5   C8y C    12.7048  -15.1697
            6   C8x C    11.4466  -14.4707
            7   C1b C    13.8932  -14.4707
            8   C1b C    15.1515  -15.1697
            9   C1b C    16.3398  -14.4707
            10  C1b C    17.5282  -15.1697
            11  P1a P    18.7864  -14.4707
            12  C1b C    19.9748  -15.1697
            13  C5a C    21.1631  -14.4707
            14  N1y N    22.4214  -15.1697
            15  O3b O    18.7864  -13.0028
            16  O5a O    21.1631  -13.0727
            17  C1x C    22.8408  -16.4978
            18  C1y C    24.2389  -16.4978
            19  C1x C    24.6583  -15.1697
            20  C1y C    23.5398  -14.3309
            21  C1y C    24.9379  -17.7561
            22  C1x C    24.2389  -18.9444
            23  C1x C    24.9379  -20.1328
            24  C1x C    26.3360  -20.1328
            25  C1x C    27.0350  -18.9444
            26  C1x C    26.3360  -17.7561
            27  C6a C    23.5398  -12.9329
            28  O6a O    24.7282  -12.2338 #-
            29  O6a O    22.3515  -12.2338
            30  O2b O    18.7864  -16.0085
            31  C1c C    18.7864  -17.4066
            32  O7a O    17.5981  -18.1056
            33  C1c C    19.9748  -18.1056
            34  C1a C    21.1631  -17.4066
            35  C1a C    19.9748  -19.5037
            36  C7a C    16.4097  -17.4066
            37  C1b C    15.2214  -18.1056
            38  O6a O    16.4097  -16.0085
            39  C1a C    14.0330  -17.4066
            40  Z   Na   26.2661  -12.2338 #+
BOND        41
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   11  15 2
            16   13  16 2
            17   14  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   14  20 1
            22   21  22 1
            23   22  23 1
            24   23  24 1
            25   24  25 1
            26   25  26 1
            27   21  26 1
            28   18  21 1 #Up
            29   20  27 1 #Down
            30   27  28 1
            31   27  29 2
            32   11  30 1
            33   30  31 1
            34   31  32 1 #Up
            35   31  33 1
            36   33  34 1
            37   33  35 1
            38   32  36 1
            39   36  37 1
            40   36  38 2
            41   37  39 1