Entry

D00630                      Drug

Name

Isosorbide mononitrate (JP18/USP/INN);
Imdur (TN);
Ismo (TN)

Product

MONOKET (Lannett Company)

Generic

ISOSORBIDE MONONITRATE (A-S Medication Solutions), ISOSORBIDE MONONITRATE (A-S Medication Solutions), ISOSORBIDE MONONITRATE (A-S Medication Solutions), ISOSORBIDE MONONITRATE (A-S Medication Solutions), ISOSORBIDE MONONITRATE (Actavis Pharma), ISOSORBIDE MONONITRATE (American Health Packaging), ISOSORBIDE MONONITRATE (Aphena Pharma Solutions - Tennessee), ISOSORBIDE MONONITRATE (Aphena Pharma Solutions - Tennessee), ISOSORBIDE MONONITRATE (Aphena Pharma Solutions - Tennessee), ISOSORBIDE MONONITRATE (Aphena Pharma Solutions - Tennessee), ISOSORBIDE MONONITRATE (AvPAK), ISOSORBIDE MONONITRATE (Bryant Ranch Prepack), ISOSORBIDE MONONITRATE (Bryant Ranch Prepack), ISOSORBIDE MONONITRATE (Bryant Ranch Prepack), ISOSORBIDE MONONITRATE (Bryant Ranch Prepack), ISOSORBIDE MONONITRATE (Cardinal Health), ISOSORBIDE MONONITRATE (Cardinal Health), ISOSORBIDE MONONITRATE (Denton Pharma), ISOSORBIDE MONONITRATE (Golden State Medical Supply), ISOSORBIDE MONONITRATE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), ISOSORBIDE MONONITRATE (Ingenus Pharmaceuticals), ISOSORBIDE MONONITRATE (Lannett Company), ISOSORBIDE MONONITRATE (Lannett Company), ISOSORBIDE MONONITRATE (Major Pharmaceuticals), ISOSORBIDE MONONITRATE (NCS HealthCare of KY), ISOSORBIDE MONONITRATE (NCS HealthCare of KY), ISOSORBIDE MONONITRATE (NCS HealthCare of KY), ISOSORBIDE MONONITRATE (Northwind Pharmaceuticals), ISOSORBIDE MONONITRATE (NuCare Pharmaceuticals), ISOSORBIDE MONONITRATE (NuCare Pharmaceuticals), ISOSORBIDE (NuCare Pharmaceuticals), ISOSORBIDE (NuCare Pharmaceuticals), ISOSORBIDE MONONITRATE (PD-Rx Pharmaceuticals), ISOSORBIDE MONONITRATE (Proficient Rx LP), ISOSORBIDE MONONITRATE (Proficient Rx LP), ISOSORBIDE MONONITRATE (REMEDYREPACK), ISOSORBIDE MONONITRATE (REMEDYREPACK), ISOSORBIDE MONONITRATE (REMEDYREPACK), ISOSORBIDE MONONITRATE (REMEDYREPACK), ISOSORBIDE MONONITRATE (REMEDYREPACK), ISOSORBIDE MONONITRATE (REMEDYREPACK), ISOSORBIDE MONONITRATE (REMEDYREPACK), ISOSORBIDE MONONITRATE (REMEDYREPACK), ISOSORBIDE MONONITRATE (REMEDYREPACK), ISOSORBIDE MONONITRATE (REMEDYREPACK), ISOSORBIDE MONONITRATE (RPK Pharmaceuticals), ISOSORBIDE MONONITRATE (Torrent Pharmaceuticals Limited), ISOSORBIDE MONONITRATE ER (Direct Rx), TIMOLOL MALEATE (Akorn)

Formula

C6H9NO6

Exact mass

191.043

Mol weight

191.1388

Structure

Simcomp

Class

Cardiovascular agent
DG01657 Nitrovasodilator

Remark

Same as:

C07714

Therapeutic category:

2171

ATC code:

C01DA14

Chemical structure group:

DG01270

Product (DG01270):

D00516<JP/US> D00630<JP/US>

Efficacy

Vasodilator (coronary)

Disease

Angina pectoris [DS:H01632]

Comment

Organic nitrate
Osmotic diuretic
Nitric oxide donor

Interaction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01D VASODILATORS USED IN CARDIAC DISEASES
    C01DA Organic nitrates
     C01DA14 Isosorbide mononitrate
      D00630  Isosorbide mononitrate (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
  Vasodilators
   Direct-acting Arterial/Venous
    Isosorbide Mononitrate
     D00630  Isosorbide mononitrate (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  21  Cardiovascular agents
   217  Vasodilators
    2171  Coronary dilators
     D00630  Isosorbide mononitrate (JP18/USP/INN)
Drug groups [BR:br08330]
Cardiovascular agent
  DG01657  Nitrovasodilator
   DG01270  Isosorbide nitrate
    D00630  Isosorbide mononitrate
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00630  Isosorbide mononitrate tablets
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
  D00630
Drug groups [BR:br08330]
Cardiovascular agent
  DG01657  Nitrovasodilator
   DG01270  Isosorbide nitrate

Other DBs

CAS:	16051-77-7

PubChem:

7847696

ChEBI:

6062

LigandBox:

D00630

NIKKAJI:

J22.753F

KCF data

ATOM        13
            1   C1y C    32.1300  -17.9200
            2   C1y C    32.1300  -16.5200
            3   C1y C    30.8000  -16.1000
            4   C1x C    30.0300  -17.2200
            5   O2x O    30.8000  -18.3400
            6   C1y C    33.4600  -18.3400
            7   C1x C    34.2300  -17.2200
            8   O2x O    33.4600  -16.1000
            9   O2a O    33.8100  -19.6700
            10  O1a O    30.3800  -14.7700
            11  N2b N    35.2100  -19.6700 #+
            12  O3a O    35.9100  -20.8600 #-
            13  O3a O    35.9100  -18.3400
BOND        14
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     1   6 1
            7     6   7 1
            8     7   8 1
            9     2   8 1
            10    6   9 1 #Up
            11    3  10 1 #Down
            12    9  11 1
            13   11  12 1
            14   11  13 2