Entry

D00640                      Drug

Name

Propafenone hydrochloride (JP18/USP);
Rythmol (TN)

Product

RYTHMOL (GlaxoSmithKline LLC)

Generic

PROPAFENONE HYDROCHLORIDE (Golden State Medical Supply), PROPAFENONE HYDROCHLORIDE (Proficient Rx LP), PROPAFENONE HYDROCHLORIDE (TWi Pharmaceuticals), PROPAFENONE HYDROCHLORIDE (Vitruvias Therapeutics), PROPAFENONE HYDROCHLORIDE (A-S Medication Solutions), PROPAFENONE HYDROCHLORIDE (A-S Medication Solutions), PROPAFENONE HCL (A-S Medication Solutions), PROPAFENONE HYDROCHLORIDE (ANI Pharmaceuticals), PROPAFENONE HYDROCHLORIDE (Actavis Pharma), PROPAFENONE HCL (Actavis Pharma), PROPAFENONE HYDROCHLORIDE (American Health Packaging), PROPAFENONE HYDROCHLORIDE (American Health Packaging), PROPAFENONE HYDROCHLORIDE (American Health Packaging), PROPAFENONE HYDROCHLORIDE (American Health Packaging), PROPAFENONE HYDROCHLORIDE (Aurobindo Pharma Limited), PROPAFENONE HYDROCHLORIDE (AvKARE), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Bryant Ranch Prepack), PROPAFENONE HYDROCHLORIDE (Cadila Healthcare Limited), PROPAFENONE HYDROCHLORIDE (Glenmark Pharmaceuticals), PROPAFENONE HYDROCHLORIDE (Golden State Medical Supply), PROPAFENONE HYDROCHLORIDE (Golden State Medical Supply), PROPAFENONE HYDROCHLORIDE (Golden State Medical Supply), PROPAFENONE HYDROCHLORIDE (Northstar Rx LLC), PROPAFENONE HYDROCHLORIDE (Par Pharmaceutical), PROPAFENONE HYDROCHLORIDE (Par Pharmaceutical), PROPAFENONE HYDROCHLORIDE (Rising Pharma Holdings), PROPAFENONE HYDROCHLORIDE (Strides Pharma Science Limited), PROPAFENONE HYDROCHLORIDE (Strides Pharma Science Limited), PROPAFENONE HYDROCHLORIDE (Sun Pharmaceutical Industries), PROPAFENONE HYDROCHLORIDE (Upsher-Smith Laboratories), PROPAFENONE HYDROCHLORIDE (Zydus Pharmaceuticals (USA))

Formula

C21H27NO3. HCl

Exact mass

377.1758

Mol weight

377.9049

Structure

Simcomp

Class

Cardiovascular agent
DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01650  Class Ic antiarrhythmic agent
Metabolizing enzyme substrate
DG01892  CYP1A2 substrate
DG01644  CYP2D6 substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate

Remark

Therapeutic category:

2129

ATC code:

C01BC03

Chemical structure group:

DG00200

Product (DG00200):

D00640<JP/US>

Efficacy

Antiarrhythmic, Sodium channel blocker

Target

SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]

Pathway

hsa04261

Adrenergic signaling in cardiomyocytes

hsa04728

Dopaminergic synapse

Metabolism

Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576], CYP1A2 [HSA:1544]

Interaction

Structure map

map07037

Antiarrhythmic drugs

map07231

Sodium channel blocking drugs

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BC Antiarrhythmics, class Ic
     C01BC03 Propafenone
      D00640  Propafenone hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
  Antiarrhythmics
   Vaughn Williams-Class I
    Propafenone
     D00640  Propafenone hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D00640  Propafenone hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01650  Class Ic antiarrhythmic agent
     DG00200  Propafenone
      D00640  Propafenone hydrochloride
Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00200  Propafenone
    D00640  Propafenone hydrochloride
  DG01644  CYP2D6 substrate
   DG00200  Propafenone
    D00640  Propafenone hydrochloride
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00200  Propafenone
     D00640  Propafenone hydrochloride
Drug classes [BR:br08332]
Cardiovascular agent
  DG01653  Antiarrhythmics
   D00640  Propafenone hydrochloride
Target-based classification of drugs [BR:br08310]
Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00640  Propafenone hydrochloride (JP18/USP) <JP/US>
    SCN2A
     D00640  Propafenone hydrochloride (JP18/USP) <JP/US>
    SCN3A
     D00640  Propafenone hydrochloride (JP18/USP) <JP/US>
    SCN4A
     D00640  Propafenone hydrochloride (JP18/USP) <JP/US>
    SCN5A
     D00640  Propafenone hydrochloride (JP18/USP) <JP/US>
    SCN8A
     D00640  Propafenone hydrochloride (JP18/USP) <JP/US>
    SCN9A
     D00640  Propafenone hydrochloride (JP18/USP) <JP/US>
    SCN10A
     D00640  Propafenone hydrochloride (JP18/USP) <JP/US>
    SCN11A
     D00640  Propafenone hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00640  Propafenone hydrochloride
  D00640  Propafenone hydrochloride tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00640
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
  D00640
Drug groups [BR:br08330]
Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01650  Class Ic antiarrhythmic agent
     DG00200  Propafenone
Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00200  Propafenone
  DG01644  CYP2D6 substrate
   DG00200  Propafenone
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00200  Propafenone

Other DBs

CAS:	34183-22-7

PubChem:

7847706

ChEBI:

8466

LigandBox:

D00640

NIKKAJI:

J252.813D

KCF data

ATOM        26
            1   C8y C    27.3415  -18.7772
            2   C8y C    27.3474  -20.1862
            3   O2a O    26.1247  -18.0844
            4   C8x C    28.5641  -18.0785
            5   C5a C    26.1363  -20.8906
            6   C8x C    28.5641  -20.8849
            7   C1b C    26.1363  -16.6871
            8   C8x C    29.7753  -18.7772
            9   C1b C    24.9311  -20.1919
            10  O5a O    26.1422  -22.2880
            11  C8x C    29.7693  -20.1803
            12  C1c C    24.9311  -15.9825
            13  C1b C    23.7259  -20.8965
            14  C1b C    23.7259  -16.6928
            15  O1a O    24.9253  -14.5851
            16  C8y C    22.5090  -20.2036
            17  N1b N    22.5149  -15.9941
            18  C8x C    22.5090  -18.8005
            19  C8x C    21.3097  -20.9082
            20  C1b C    21.3097  -16.6987
            21  C8x C    21.2921  -18.1135
            22  C8x C    20.0869  -20.2212
            23  C1b C    20.0928  -16.0000
            24  C8x C    20.0754  -18.8121
            25  C1a C    18.8819  -16.7045
            26  X   Cl   31.8596  -18.4395
BOND        26
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 1
            8     5   9 1
            9     5  10 2
            10    6  11 1
            11    7  12 1
            12    9  13 1
            13   12  14 1
            14   12  15 1
            15   13  16 1
            16   14  17 1
            17   16  18 2
            18   16  19 1
            19   17  20 1
            20   18  21 1
            21   19  22 2
            22   20  23 1
            23   21  24 2
            24   23  25 1
            25    8  11 2
            26   22  24 1