Methazolamide

Entry

D00655                      Drug

Name

Methazolamide (JAN/USP/INN);
Neptazane (TN)

Product

Generic

METHAZOLAMIDE (A-S Medication Solutions), METHAZOLAMIDE (ANI Pharmaceuticals), METHAZOLAMIDE (Bausch & Lomb Incorporated), METHAZOLAMIDE (Bryant Ranch Prepack), METHAZOLAMIDE (Bryant Ranch Prepack), METHAZOLAMIDE (Bryant Ranch Prepack), METHAZOLAMIDE (Effcon Laboratories), METHAZOLAMIDE (Golden State Medical Supply), METHAZOLAMIDE (Micro Labs Limited), METHAZOLAMIDE (Oceanside Pharmaceuticals), METHAZOLAMIDE (Padagis US LLC)

Formula

C5H8N4O3S2

Exact mass

236.0038

Mol weight

236.272

Structure

Simcomp

Class

Cardiovascular agent
DG01534 Carbonic anhydrase inhibitor
Ophthalmic agent
DG03201 Intraocular pressure lowering agent

Remark

Same as:

C07764

ATC code:

S01EC05

Product:

D00655<US>

Efficacy

Antiglaucoma, Carbonic anhydrase inhibitor

Disease

Open-angle glaucoma [DS:H00612]

Target

CA [HSA:759 760 761 762 763 11238 765 766 767 768 771 377677 23632] [KO:K01672 K18245 K18246]

Pathway

hsa04964

Proximal tubule bicarbonate reclamation

Interaction

Structure map

map07017

Sulfonamide derivatives - diuretics

map07054

Antiglaucoma agents

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EC Carbonic anhydrase inhibitors
     S01EC05 Methazolamide
      D00655  Methazolamide (JAN/USP/INN) <US>
USP drug classification [BR:br08302]
Ophthalmic Agents
  Intraocular Pressure Lowering Agents
   Carbonic Anhydrase Inhibitors, Ophthalmic
    Methazolamide
     D00655  Methazolamide (JAN/USP/INN)
Drug groups [BR:br08330]
Cardiovascular agent
  DG01534  Carbonic anhydrase inhibitor
   D00655  Methazolamide
Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   D00655  Methazolamide
Drug classes [BR:br08332]
Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   D00655  Methazolamide
Target-based classification of drugs [BR:br08310]
Enzymes
  Lyases (EC4)
   Aldehyde-lyases
    CA
     D00655  Methazolamide (JAN/USP/INN) <US>

Other DBs

CAS:

554-57-4

PubChem:

7847721

ChEBI:

6822

LigandBox:

D00655

NIKKAJI:

J2.070B

KCF data

ATOM        14
            1   C8y C    26.4566  -18.5315
            2   S2x S    25.3215  -17.7066
            3   N4y N    26.0236  -19.8597
            4   N2b N    27.6618  -17.8177
            5   C8y C    24.1866  -18.5315
            6   N5x N    24.6254  -19.8597
            7   C1a C    26.8486  -20.9889
            8   C5a C    28.8729  -18.5198
            9   S4a S    22.7882  -18.5258
            10  C1a C    30.0841  -17.8120
            11  O5a O    28.8729  -19.9183
            12  N1a N    22.8465  -19.9240
            13  O3c O    22.8465  -17.1273
            14  O3c O    21.3840  -18.5258
BOND        14
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 1
            8     5   9 1
            9     8  10 1
            10    8  11 2
            11    9  12 1
            12    9  13 2
            13    9  14 2
            14    5   6 2