| Entry |
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| Name | Diphenhydramine hydrochloride (JP18/USP); Benadryl (TN) | ||||||||||||
| Product | |||||||||||||
| Generic | DIPHENHYDRAMINE HCI (HF Acquisition Co LLC), DIPHENHYDRAMINE HYDROCHLORIDE (A-S Medication Solutions), DIPHENHYDRAMINE HYDROCHLORIDE (A-S Medication Solutions), DIPHENHYDRAMINE HYDROCHLORIDE (Armas Pharmaceuticals), DIPHENHYDRAMINE HYDROCHLORIDE (Cardinal Health), DIPHENHYDRAMINE HYDROCHLORIDE (Cardinal Health), DIPHENHYDRAMINE HYDROCHLORIDE (Fresenius Kabi USA), DIPHENHYDRAMINE (Fresenius Kabi USA), DIPHENHYDRAMINE (Fresenius Kabi USA), DIPHENHYDRAMINE HYDROCHLORIDE (General Injectables & Vaccines), DIPHENHYDRAMINE HYDROCHLORIDE (HF Acquisition Co LLC), DIPHENHYDRAMINE HYDROCHLORIDE (HF Acquisition Co LLC), DIPHENHYDRAMINE HYDROCHLORIDE (HF Acquisition Co. LLC), DIPHENHYDRAMINE HYDROCHLORIDE (Henry Schein), DIPHENHYDRAMINE HYDROCHLORIDE (Hikma Pharmaceuticals USA), DIPHENHYDRAMINE HYDROCHLORIDE (Medical Purchasing Solutions), DIPHENHYDRAMINE HYDROCHLORIDE (Medical Purchasing Solutions), DIPHENHYDRAMINE HYDROCHLORIDE (Medical Purchasing Solutions), DIPHENHYDRAMINE (Micro Labs Limited), DIPHENHYDRAMINE HYDROCHLORIDE (Mylan Institutional LLC), DIPHENHYDRAMINE HYDROCHLORIDE (Pharmaceutical Associates), DIPHENHYDRAMINE HYDROCHLORIDE (REMEDYREPACK), DIPHENHYDRAMINE HYDROCHLORIDE (REMEDYREPACK) | ||||||||||||
| Formula | C17H21NO. HCl | ||||||||||||
| Exact mass | 291.139 | ||||||||||||
| Mol weight | 291.8157 | ||||||||||||
| Structure |  | ||||||||||||
| Simcomp | |||||||||||||
| Class | Anti-allergic agent DG01557 Histamine receptor antagonist DG01482 Histamine receptor H1 antagonist | ||||||||||||
| Remark |
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| Efficacy | Antiallergic, H1 receptor antagonist | ||||||||||||
| Disease | Parkinsonism [DS:H01600] Nighttime sleep-aid [DS:H01609] | ||||||||||||
| Comment | Diphenhydramine derivative | ||||||||||||
| Target | HRH1 [HSA:3269] [KO:K04149] | ||||||||||||
| Pathway |
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| Interaction | |||||||||||||
| Structure map |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] D DERMATOLOGICALS D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. D04AA Antihistamines for topical use D04AA32 Diphenhydramine D00669 Diphenhydramine hydrochloride (JP18/USP) <JP/US> R RESPIRATORY SYSTEM R06 ANTIHISTAMINES FOR SYSTEMIC USE R06A ANTIHISTAMINES FOR SYSTEMIC USE R06AA Aminoalkyl ethers R06AA02 Diphenhydramine D00669 Diphenhydramine hydrochloride (JP18/USP) <JP/US> USP drug classification [BR:br08302] Antiemetics Antiemetics, Other Diphenhydramine D00669 Diphenhydramine hydrochloride (JP18/USP) Antiparkinson Agents Anticholinergics Diphenhydramine D00669 Diphenhydramine hydrochloride (JP18/USP) Respiratory Tract/Pulmonary Agents Antihistamines Histamine (H1) Receptor Antagonists, Sedating Diphenhydramine D00669 Diphenhydramine hydrochloride (JP18/USP) Therapeutic category of drugs in Japan [BR:br08301] 4 Agents affecting cellular function 44 Allergic agents 441 Antihistamines 4411 Diphenhydramines D00669 Diphenhydramine hydrochloride (JP18/USP) Classification of Japanese OTC drugs [BR:br08313] Agents for nervous and sensory systems 01 Cold remedy (oral use) D00669 Diphenhydramine hydrochloride (JP18/USP) 04 Sedative hypnotic agents D00669 Diphenhydramine hydrochloride (JP18/USP) 06 Antivertigo drugs (incl. motion/morning sickness remedies) D00669 Diphenhydramine hydrochloride (JP18/USP) Allergic agents 52 Antihistamine based drugs D00669 Diphenhydramine hydrochloride (JP18/USP) Agents for integumentary system 57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches) D00669 Diphenhydramine hydrochloride (JP18/USP) Agents for ophthalmologic use 64 Allergy eye drops D00669 Diphenhydramine hydrochloride (JP18/USP) Risk category of Japanese OTC drugs [BR:br08312] Designated second-class OTC drugs Inorganic and organic chemicals Diphenhydramine D00669 Diphenhydramine hydrochloride (JP18/USP) Second-class OTC drugs Inorganic and organic chemicals Diphenhydramine D00669 Diphenhydramine hydrochloride (JP18/USP) Third-class OTC drugs Inorganic and organic chemicals Diphenhydramine D00669 Diphenhydramine hydrochloride (JP18/USP) Drug groups [BR:br08330] Anti-allergic agent DG01557 Histamine receptor antagonist DG01482 Histamine receptor H1 antagonist DG00390 Diphenhydramine D00669 Diphenhydramine hydrochloride Drug classes [BR:br08332] Anti-allergic agent DG01482 Histamine receptor H1 antagonist D00669 Diphenhydramine hydrochloride Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Rhodopsin family Histamine HRH1 D00669 Diphenhydramine hydrochloride (JP18/USP) <JP/US> Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D00669 Diphenhydramine hydrochloride Rx-to-OTC switch list in the USA [br08315.html] D00669 Drug groups [BR:br08330] Anti-allergic agent DG01557 Histamine receptor antagonist DG01482 Histamine receptor H1 antagonist DG00390 Diphenhydramine | ||||||||||||
| Other DBs |
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| KCF data | ATOM 20 1 X Cl 34.6500 -16.2400 2 C1c C 28.0247 -15.1856 3 C8y C 26.8139 -15.8899 4 C8y C 29.2415 -15.8899 5 O2a O 28.0306 -13.7884 6 C8x C 26.8139 -17.2930 7 C8x C 25.6030 -15.1856 8 C8x C 29.2358 -17.2930 9 C8x C 30.4465 -15.1856 10 C1b C 29.2415 -13.0840 11 C8x C 25.6030 -17.9856 12 C8x C 24.3862 -15.8899 13 C8x C 30.4465 -17.9856 14 C8x C 31.6632 -15.8899 15 C8x C 24.3862 -17.2930 16 C8x C 31.6573 -17.2930 17 C1b C 30.4774 -13.7950 18 N1c N 31.6739 -13.1016 19 C1a C 32.8632 -13.7857 20 C1a C 31.6717 -11.6927 BOND 20 1 6 11 2 2 7 12 1 3 8 13 1 4 9 14 2 5 11 15 1 6 13 16 2 7 12 15 2 8 14 16 1 9 2 3 1 10 2 4 1 11 2 5 1 12 3 6 1 13 3 7 2 14 4 8 2 15 4 9 1 16 5 10 1 17 10 17 1 18 17 18 1 19 18 19 1 20 18 20 1 |