| Entry |
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|---|---|---|---|---|---|---|---|---|---|---|---|
| Name | Ranitidine hydrochloride (JP18/USP); Zantac (TN) | ||||||||||
| Product | |||||||||||
| Generic | RANITIDINE (A-S Medication Solutions), RANITIDINE (Ajanta Pharma USA), RANITIDINE (Amneal Pharmaceuticals LLC), RANITIDINE (Amneal Pharmaceuticals LLC), RANITIDINE (Amneal Pharmaceuticals of New York LLC), RANITIDINE (Aphena Pharma Solutions - Tennessee), RANITIDINE (Aphena Pharma Solutions - Tennessee), RANITIDINE (Aphena Pharma Solutions - Tennessee), RANITIDINE (Aphena Pharma Solutions - Tennessee), RANITIDINE (Aphena Pharma Solutions - Tennessee), RANITIDINE (Aphena Pharma Solutions - Tennessee), RANITIDINE (Bryant Ranch Prepack), RANITIDINE (Bryant Ranch Prepack), RANITIDINE (Bryant Ranch Prepack), RANITIDINE (Bryant Ranch Prepack), RANITIDINE (Bryant Ranch Prepack), RANITIDINE (Bryant Ranch Prepack), RANITIDINE (Bryant Ranch Prepack), RANITIDINE (Bryant Ranch Prepack), RANITIDINE (Bryant Ranch Prepack), RANITIDINE (Glenmark Pharmaceuticals), RANITIDINE (Golden State Medical Supply), RANITIDINE (Medsource Pharmaceuticals), RANITIDINE (NuCare Pharmaceuticals), RANITIDINE (NuCare Pharmaceuticals), RANITIDINE (NuCare Pharmaceuticals), RANITIDINE (NuCare Pharmaceuticals), RANITIDINE (NuCarePharmaceuticals), RANITIDINE (Pharmaceutical Associates), RANITIDINE (RedPharm Drug), RANITIDINE (Strides Pharma Science Limited), RANITIDINE (A-S Medication Solutions), RANITIDINE HYDROCHLORIDE (Cadila Healthcare Limited), RANITIDINE HYDROCHLORIDE (Cadila Healthcare Limited), RANITIDINE HYDROCHLORIDE (Dr. Reddy's Laboratories Limited), RANITIDINE (Lannett Company), RANITIDINE HYDROCHLORIDE (Sandoz), RANITIDINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), RANITIDINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA)) | ||||||||||
| Formula | C13H22N4O3S. HCl | ||||||||||
| Exact mass | 350.1179 | ||||||||||
| Mol weight | 350.8647 | ||||||||||
| Structure |  | ||||||||||
| Simcomp | |||||||||||
| Class | Gastrointestinal agent DG01975 Agents for peptic ulcer DG01481 Histamine receptor H2 antagonist Metabolizing enzyme inhibitor DG01645 CYP2D6 inhibitor DG02852 CYP3A/CYP3A4 inhibitor Transporter substrate DG02854 SLC22A2 substrate Transporter inhibitor DG02863 SLC22A2 inhibitor | ||||||||||
| Remark |
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| Efficacy | Anti-ulcerative, H2 receptor antagonist | ||||||||||
| Disease | Duodenal ulcer [DS:H01634] Zollinger-Ellison syndrome [DS:H01522] Gastric ulcer [DS:H01634] GERD [DS:H01602] | ||||||||||
| Target | HRH2 [HSA:3274] [KO:K04150] | ||||||||||
| Pathway |
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| Metabolism | Transporter: SLC22A2 [HSA:6582] | ||||||||||
| Interaction | CYP inhibition: CYP2D6 [HSA:1565], CYP3A [HSA:1576 1577 1551] Transporter inhibition: SLC22A2 [HSA:6582] | ||||||||||
| Structure map |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] A ALIMENTARY TRACT AND METABOLISM A02 DRUGS FOR ACID RELATED DISORDERS A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) A02BA H2-receptor antagonists A02BA02 Ranitidine D00673 Ranitidine hydrochloride (JP18/USP) <JP/US> USP drug classification [BR:br08302] Gastrointestinal Agents Histamine2 (H2) Receptor Antagonists Ranitidine D00673 Ranitidine hydrochloride (JP18/USP) Therapeutic category of drugs in Japan [BR:br08301] 2 Agents affecting individual organs 23 Digestive organ agents 232 Peptic ulcer agents 2325 H2 blockers D00673 Ranitidine hydrochloride (JP18/USP) Classification of Japanese OTC drugs [BR:br08313] Agents for digestive organs 09 Histamine H2 receptor blocker containing drugs D00673 Ranitidine hydrochloride (JP18/USP) Risk category of Japanese OTC drugs [BR:br08312] First-class OTC drugs Inorganic and organic chemicals Ranitidine D00673 Ranitidine hydrochloride (JP18/USP) Drug groups [BR:br08330] Gastrointestinal agent DG01975 Agents for peptic ulcer DG01481 Histamine receptor H2 antagonist DG00018 Ranitidine D00673 Ranitidine hydrochloride Metabolizing enzyme inhibitor DG01645 CYP2D6 inhibitor DG00018 Ranitidine D00673 Ranitidine hydrochloride DG02852 CYP3A/CYP3A4 inhibitor DG00018 Ranitidine D00673 Ranitidine hydrochloride Transporter substrate DG02854 SLC22A2 substrate DG00018 Ranitidine D00673 Ranitidine hydrochloride Transporter inhibitor DG02863 SLC22A2 inhibitor DG00018 Ranitidine D00673 Ranitidine hydrochloride Drug classes [BR:br08332] Gastrointestinal agent DG01481 Histamine receptor H2 antagonist D00673 Ranitidine hydrochloride Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Rhodopsin family Histamine HRH2 D00673 Ranitidine hydrochloride (JP18/USP) <JP/US> Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D00673 Ranitidine hydrochloride Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D00673 Drug transporters D00673 Rx-to-OTC switch list in Japan [br08314.html] D00673 Drug groups [BR:br08330] Gastrointestinal agent DG01975 Agents for peptic ulcer DG01481 Histamine receptor H2 antagonist DG00018 Ranitidine Metabolizing enzyme inhibitor DG01645 CYP2D6 inhibitor DG00018 Ranitidine DG02852 CYP3A/CYP3A4 inhibitor DG00018 Ranitidine Transporter substrate DG02854 SLC22A2 substrate DG00018 Ranitidine Transporter inhibitor DG02863 SLC22A2 inhibitor DG00018 Ranitidine | ||||||||||
| Other DBs |
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| KCF data | ATOM 22 1 C8y C 19.1062 -21.6933 2 O2x O 20.2292 -22.5356 3 C8x C 19.5273 -20.3597 4 C1b C 17.8427 -22.3952 5 C8y C 21.3523 -21.6933 6 C8x C 20.9311 -20.3597 7 N1c N 16.6495 -21.6933 8 C1b C 22.5455 -22.3952 9 C1a C 15.4562 -22.3952 10 C1a C 16.6495 -20.2895 11 S2a S 23.7388 -21.6933 12 C1b C 25.0022 -22.3952 13 C1b C 26.1956 -21.6933 14 N1b N 27.3890 -22.3952 15 C2c C 28.5822 -21.6933 16 C2b C 29.8457 -22.3952 17 N1b N 28.5822 -20.2895 18 N2b N 31.0389 -21.6933 #+ 19 C1a C 27.3890 -19.5875 20 O3a O 31.0389 -20.2895 #- 21 O3a O 32.2322 -22.3952 22 X Cl 30.1262 -25.5343 BOND 21 1 1 2 1 2 1 3 2 3 1 4 1 4 2 5 1 5 3 6 1 6 4 7 1 7 5 8 1 8 7 9 1 9 7 10 1 10 8 11 1 11 11 12 1 12 12 13 1 13 13 14 1 14 14 15 1 15 15 16 2 16 15 17 1 17 16 18 1 18 17 19 1 19 18 20 1 20 18 21 2 21 5 6 2 |