Entry

D00676                      Drug

Name

Sumatriptan succinate (JAN/USP);
Alsuma (TN);
Imitrex (TN);
Sumave dosepro (TN);
Zecutity (TN)

Product

IMITREX (GlaxoSmithKline LLC), IMITREX (GlaxoSmithKline LLC), ZEMBRACE SYMTOUCH (Promius Pharma), ONZETRA XSAIL (Currax Pharmaceuticals LLC), ZEMBRACE SYMTOUCH (Upsher-Smith laboratories)

Generic

SUMATRIPTAN (A-S Medication Solutions), SUMATRIPTAN (A-S Medication Solutions), SUMATRIPTAN (AuroMedics Pharma LLC), SUMATRIPTAN (AuroMedics Pharma LLC), SUMATRIPTAN (Bionpharma), SUMATRIPTAN (Caplin Steriles Limited), SUMATRIPTAN (Golden State Medical Supply), SUMATRIPTAN (OrchidPharma), SUMATRIPTAN (Prasco Laboratories), SUMATRIPTAN (Proficient Rx LP), SUMATRIPTAN (Proficient Rx LP), SUMATRIPTAN (Quality Care Products), SUMATRIPTAN (Quality Care Products), SUMATRIPTAN (RPK Pharmaceuticals), SUMATRIPTAN (SUN PHARMACEUTICAL INDUSTRIES), SUMATRIPTAN (Somerset Therapeutics), SUMATRIPTAN (West-Ward Pharmaceuticals Corp), SUMATRIPTAN (A-S Medication Solutions), SUMATRIPTAN SUCCINATE (A-S Medication Solutions), SUMATRIPTAN SUCCINATE (Asclemed USA), SUMATRIPTAN (Aurobindo Pharma Limited), SUMATRIPTAN (Bryant Ranch Prepack), SUMATRIPTAN SUCCINATE (Dr. Reddy's Laboratories Limited), SUMATRIPTAN SUCCINATE (Dr. Reddy's Laboratories Limited), SUMATRIPTAN SUCCINATE (Fresenius Kabi USA), SUMATRIPTAN SUCCINATE (Golden State Medical Supply), SUMATRIPTAN (Golden State Medical Supply), SUMATRIPTAN SUCCINATE (Lake Erie Medical DBA Quality Care Products LLC), SUMATRIPTAN SUCCINATE (Medsource Pharmaceuticals), SUMATRIPTAN SUCCINATE (Mylan Pharmaceuticals), SUMATRIPTAN (NorthStar Rx LLC), SUMATRIPTAN SUCCINATE (NorthStar Rx LLC), SUMATRIPTAN (NuCare Pharmaceuticals), SUMATRIPTAN SUCCINATE (NuCare Pharmaceuticals), SUMATRIPTAN SUCCINATE (NuCare Pharmaceuticals), SUMATRIPTAN (NuCare Pharmaceuticals), SUMATRIPTAN (NuCare Pharmaceuticals), SUMATRIPTAN SUCCINATE (NuCare Pharmaceuticals), SUMATRIPTAN SUCCINATE (Preferred Pharmaceuticals), SUMATRIPTAN (Preferred Pharmaceuticals), SUMATRIPTAN (Preferred Pharmaceuticals), SUMATRIPTAN (Preferred Pharmaceuticals), SUMATRIPTAN (Proficient Rx LP), SUMATRIPTAN SUCCINATE (Proficient Rx LP), SUMATRIPTAN SUCCINATE (Proficient Rx LP), SUMATRIPTAN SUCCINATE (Proficient Rx LP), SUMATRIPTAN SUCCINATE (Proficient Rx LP), SUMATRIPTAN (Proficient Rx LP), SUMATRIPTAN SUCCINATE (Proficient Rx LP), SUMATRIPTAN SUCCINATE (Proficient Rx LP), SUMATRIPTAN (Proficient Rx LP), SUMATRIPTAN (Quality Care Products), SUMATRIPTAN (Quality Care Products), SUMATRIPTAN (Quality Care Products), SUMATRIPTAN SUCCINATE (Quality Care Products), SUMATRIPTAN SUCCINATE (REMEDYREPACK), SUMATRIPTAN (REMEDYREPACK), SUMATRIPTAN SUCCINATE (REMEDYREPACK), SUMATRIPTAN (RPK Pharmaceuticals), SUMATRIPTAN SUCCINATE (RPK Pharmaceuticals), SUMATRIPTAN SUCCINATE (Sun Pharmaceutical Industries), SUMATRIPTAN SUCCINATE (Sun Pharmaceutical Industries), SUMATRIPTAN (Teva Pharmaceuticals USA), SUMATRIPTAN SUCCINATE (Wockhardt USA LLC.), SUMATRIPTAN (Xellia Pharmaceuticals USA LLC), SUMATRIPTAN (NuCare Pharmaceuticals)

Formula

C14H21N3O2S. C4H6O4

Exact mass

413.1621

Mol weight

413.4885

Structure

Simcomp

Class

Analgesic
DG01484  5-HT1B-receptor agonist
DG01485  5-HT1D-receptor agonist
DG01518  5-HT1B/1D-receptor agonist
DG01943  Triptan
Metabolizing enzyme substrate
DG02917  MAO substrate
  DG03178  MAOA substrate

Remark

Therapeutic category:

2160

ATC code:

N02CC01

Chemical structure group:

DG00836

Product (DG00836):

D00451<JP/US> D00676<JP/US>

Product (mixture):

D11577<US>

Efficacy

Antimigraine, Vasoconstrictor, Serotonin receptor agonist

Disease

Cluster headache [DS:H01588]

Comment

Triptans

Target

HTR1B [HSA:3351] [KO:K04153]
HTR1D [HSA:3352] [KO:K04153]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04726

Serotonergic synapse

Metabolism

Enzyme: MAOA [HSA:4128]

Interaction

Structure map

map07048

Antimigraines

map07211

Serotonin receptor agonists/antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CC Selective serotonin (5HT1) agonists
     N02CC01 Sumatriptan
      D00676  Sumatriptan succinate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Antimigraine Agents
  Serotonin (5-HT) Receptor Agonists
   Sumatriptan
    D00676  Sumatriptan succinate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  21  Cardiovascular agents
   216  Vasoconstrictors
    2160  Vasoconstrictors
     D00676  Sumatriptan succinate (JAN/USP)
Drug groups [BR:br08330]
Analgesic
  DG01484  5-HT1B-receptor agonist
   DG00836  Sumatriptan
    D00676  Sumatriptan succinate
  DG01485  5-HT1D-receptor agonist
   DG00836  Sumatriptan
    D00676  Sumatriptan succinate
  DG01518  5-HT1B/1D-receptor agonist
   DG00836  Sumatriptan
    D00676  Sumatriptan succinate
  DG01943  Triptan
   DG00836  Sumatriptan
    D00676  Sumatriptan succinate
Metabolizing enzyme substrate
  DG02917  MAO substrate
   DG03178  MAOA substrate
    DG00836  Sumatriptan
     D00676  Sumatriptan succinate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    HTR1B
     D00676  Sumatriptan succinate (JAN/USP) <JP/US>
    HTR1D
     D00676  Sumatriptan succinate (JAN/USP) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D00676
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00676
Drug groups [BR:br08330]
Analgesic
  DG01484  5-HT1B-receptor agonist
   DG00836  Sumatriptan
  DG01485  5-HT1D-receptor agonist
   DG00836  Sumatriptan
  DG01518  5-HT1B/1D-receptor agonist
   DG00836  Sumatriptan
  DG01943  Triptan
   DG00836  Sumatriptan
Metabolizing enzyme substrate
  DG02917  MAO substrate
   DG03178  MAOA substrate
    DG00836  Sumatriptan

Other DBs

CAS:	103628-48-4

PubChem:

7847742

ChEBI:

64359

LigandBox:

D00676

NIKKAJI:

J528.534H

KCF data

ATOM        28
            1   C8y C    23.6794  -17.9951
            2   C8y C    23.6853  -19.3996
            3   C8y C    25.0140  -17.5639
            4   C8x C    22.4731  -17.2843
            5   N4x N    25.0197  -19.8250
            6   C8x C    22.4673  -20.0930
            7   C8x C    25.8357  -18.6886
            8   C1b C    25.3287  -16.1944
            9   C8y C    21.2553  -17.9893
            10  C8x C    21.2610  -19.3937
            11  C1b C    26.6633  -15.7807
            12  C1b C    20.0373  -17.2957
            13  N1c N    26.9720  -14.4170
            14  S4a S    18.8310  -18.0010
            15  C1a C    28.3066  -14.0033
            16  C1a C    25.9464  -13.4671
            17  N1b N    17.6247  -17.3017
            18  O3c O    19.8217  -19.0033
            19  O3c O    17.8344  -19.0033
            20  C1a C    16.4124  -18.0067
            21  C1b C    30.7583  -18.8477
            22  C1b C    31.9646  -18.1484
            23  C6a C    29.5461  -18.1543
            24  C6a C    33.1767  -18.8420
            25  O6a O    28.3397  -18.8536
            26  O6a O    29.5461  -16.7557
            27  O6a O    34.3889  -18.1426
            28  O6a O    33.1767  -20.2406
BOND        28
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     6  10 1
            10    8  11 1
            11    9  12 1
            12   11  13 1
            13   12  14 1
            14   13  15 1
            15   13  16 1
            16   14  17 1
            17   14  18 2
            18   14  19 2
            19   17  20 1
            20    5   7 1
            21    9  10 2
            22   21  22 1
            23   21  23 1
            24   22  24 1
            25   23  25 1
            26   23  26 2
            27   24  27 1
            28   24  28 2