Entry

D00690                      Drug

Name

Mometasone furoate (JAN/USP);
Asmanex (TN);
Elocon (TN)

Product

SINUVA (Intersect ENT), ASMANEX HFA (Organon LLC), ASMANEX (Organon LLC)

Generic

MOMETASONE FUROATE (Amneal Pharmaceuticals LLC), MOMETASONE FUROATE (A-S Medication Solutions), MOMETASONE FUROATE (Apotex Corp.), MOMETASONE FUROATE (Bryant Ranch Prepack), MOMETASONE FUROATE (Bryant Ranch Prepack), MOMETASONE FUROATE (Bryant Ranch Prepack), MOMETASONE FUROATE (Bryant Ranch Prepack), MOMETASONE FUROATE (Bryant Ranch Prepack), MOMETASONE FUROATE (Bryant Ranch Prepack), MOMETASONE FUROATE (Bryant Ranch Prepack), MOMETASONE FUROATE (Bryant Ranch Prepack), MOMETASONE FUROATE (Cosette Pharmaceuticals), MOMETASONE FUROATE (Cosette Pharmaceuticals), MOMETASONE FUROATE (Cosette Pharmaceuticals), MOMETASONE FUROATE (Cosette Pharmaceuticals), MOMETASONE FUROATE (E. Fougera & Co. a division of Fougera Pharmaceuticals), MOMETASONE FUROATE (E. Fougera & Co. a division of Fougera Pharmaceuticals), MOMETASONE FUROATE (E. Fougera & Co. a division of Fougera Pharmaceuticals), MOMETASONE FUROATE (Glenmark Pharmaceuticals), MOMETASONE FUROATE (Glenmark Pharmaceuticals), MOMETASONE FUROATE (Glenmark Pharmaceuticals), MOMETASONE FUROATE (Golden State Medical Supply), MOMETASONE FUROATE (NORTHSTAR RX LLC), MOMETASONE FUROATE (NuCare Pharmaceuticals), MOMETASONE FUROATE (NuCare Pharmaceuticals), MOMETASONE FUROATE (NuCare Pharmaceuticals), MOMETASONE FUROATE (Padagis Israel Pharmaceuticals), MOMETASONE FUROATE (Padagis Israel Pharmaceuticals), MOMETASONE FUROATE (Perrigo New York), MOMETASONE FUROATE (Proficient Rx LP), MOMETASONE FUROATE (Proficient Rx LP), MOMETASONE FUROATE (Proficient Rx LP), MOMETASONE FUROATE (REMEDYREPACK), MOMETASONE FUROATE (RPK Pharmaceuticals), MOMETASONE FUROATE (RPK Pharmaceuticals), MOMETASONE FUROATE (Taro Pharmaceuticals U.S.A.), MOMETASONE FUROATE (Taro Pharmaceuticals U.S.A.), MOMETASONE FUROATE (Taro Pharmaceuticals U.S.A.), MOMETASONE FUROATE (Torrent Pharmaceuticals Limited), QUINIXIL (V2 Pharma)

Formula

C27H30Cl2O6

Exact mass

520.1419

Mol weight

521.4295

Structure

Simcomp

Class

Anti-inflammatory
DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate

Remark

Same as:

C07817

Therapeutic category:

2290 2646

ATC code:

D07AC13 D07XC03 R01AD09 R03BA07

Chemical structure group:

DG00419

Product (DG00419):

D00690<JP/US> D03325<JP>

Product (mixture):

D10295<US> D11861<JP> D11862<JP>

Efficacy

Antiasthmatic, Anti-inflammatory, Glucocorticoid receptor agonist

Disease

Asthma [DS:H00079]
Seasonal allergic rhinitis [DS:H01360]

Target

NR3C1 (GR) [HSA:2908] [KO:K05771]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

Metabolism

Enzyme: CYP3A4 [HSA:1576]

Interaction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC13 Mometasone
      D00690  Mometasone furoate (JAN/USP) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XC Corticosteroids, potent, other combinations
     D07XC03 Mometasone
      D00690  Mometasone furoate (JAN/USP) <JP/US>
R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD09 Mometasone
      D00690  Mometasone furoate (JAN/USP) <JP/US>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
    R03BA Glucocorticoids
     R03BA07 Mometasone
      D00690  Mometasone furoate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Medium Potency
    Mometasone
     D00690  Mometasone furoate (JAN/USP)
Respiratory Tract/Pulmonary Agents
  Anti-inflammatories, Inhaled Corticosteroids
   Mometasone
    D00690  Mometasone furoate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  22  Respiratory organ agents
   229  Miscellaneous
    2290  Miscellaneous
     D00690  Mometasone furoate (JAN/USP)
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D00690  Mometasone furoate (JAN/USP)
Drug groups [BR:br08330]
Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00419  Mometasone
     D00690  Mometasone furoate
Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00419  Mometasone
     D00690  Mometasone furoate
Drug classes [BR:br08332]
Anti-inflammatory
  DG01955  Corticosteroid
   D00690  Mometasone furoate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00690  Mometasone furoate (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00690
Topical steroids potency [br08317.html]
Classification in the USA
  D00690
Classification in Japan
  D00690
Drug groups [BR:br08330]
Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00419  Mometasone
Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00419  Mometasone

Other DBs

CAS:	83919-23-7

PubChem:

7847756

ChEBI:

47564

PDB-CCD:

MOF[PDBj]

LigandBox:

D00690

NIKKAJI:

J258.527H

KCF data

ATOM        35
            1   C1z C    33.4094  -17.0168
            2   C1z C    32.2455  -17.6911
            3   C1y C    34.5745  -17.6967
            4   O7a O    35.2692  -15.9227
            5   C5a C    33.3979  -15.6626
            6   C1y C    32.2455  -19.0336
            7   C1x C    31.0814  -17.0111
            8   C1a C    32.2396  -16.3195
            9   C1x C    34.5676  -19.0395
            10  C1a C    35.8931  -18.0539
            11  C7a C    36.6407  -15.9227
            12  C1b C    34.5851  -14.9768
            13  O5a O    32.2109  -14.9883
            14  C1y C    31.0758  -19.7079
            15  C1y C    29.9116  -17.6852
            16  C8y C    37.3207  -14.7357
            17  O6a O    37.3207  -17.1098
            18  X   Cl   34.5736  -13.6053
            19  C1z C    29.9060  -19.0336
            20  C1x C    31.0814  -21.0563
            21  O1a O    28.7362  -16.9995
            22  C8x C    38.6969  -14.7425
            23  O2x O    36.9040  -13.4470
            24  C1z C    28.7418  -19.7079
            25  X   Cl   29.9001  -20.3763
            26  C1x C    29.9116  -21.7363
            27  C8x C    39.1183  -13.4369
            28  C8x C    38.0098  -12.6305
            29  C2y C    28.7418  -21.0620
            30  C2x C    27.5721  -19.0336
            31  C1a C    28.7303  -18.3595
            32  C2x C    27.5721  -21.7363
            33  C2x C    26.4023  -19.7079
            34  C5x C    26.4023  -21.0620
            35  O5x O    25.2268  -21.7305
BOND        39
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 1
            7     2   8 1 #Up
            8     3   9 1
            9     3  10 1 #Down
            10    4  11 1
            11    5  12 1
            12    5  13 2
            13    6  14 1
            14    7  15 1
            15   11  16 1
            16   11  17 2
            17   12  18 1
            18   14  19 1
            19   14  20 1
            20   15  21 1 #Up
            21   16  22 2
            22   16  23 1
            23   19  24 1
            24   19  25 1 #Down
            25   20  26 1
            26   22  27 1
            27   23  28 1
            28   24  29 1
            29   24  30 1
            30   24  31 1 #Up
            31   29  32 2
            32   30  33 2
            33   32  34 1
            34   34  35 2
            35    6   9 1
            36   15  19 1
            37   26  29 1
            38   27  28 2
            39   33  34 1