Entry

D00711                      Drug

Name

Ketamine hydrochloride (JP18/USP);
Ketalar (TN)

Product

KETALAR (General Injectables & Vaccines), KETALAR (Henry Schein), KETALAR (Par Pharmaceutical)

Generic

KETAMINE HYDROCHLORIDE (AuroMedics Pharma LLC), KETAMINE HYDROCHLORIDE (Civica), KETAMINE HYDROCHLORIDE (General Injectables & Vaccines), KETAMINE HYDROCHLORIDE (General Injectables & Vaccines), KETAMINE HYDROCHLORIDE (Henry Schein), KETAMINE HYDROCHLORIDE (Henry Schein), KETAMINE HYDROCHLORIDE (Hikma Pharmaceuticals USA), KETAMINE HYDROCHLORIDE (Hospira), KETAMINE HYDROCHLORIDE (Medical Purchasing Solutions), KETAMINE HYDROCHLORIDE (Mylan Institutional LLC)

Formula

C13H16ClNO. HCl

Exact mass

273.0687

Mol weight

274.1862

Structure

Simcomp

Class

Neuropsychiatric agent
DG02030  Anesthetics
  DG02027  General anesthetics
DG01498  NMDA receptor antagonist

Remark

Same as:

C07843

Therapeutic category:

1119

ATC code:

N01AX03

Chemical structure group:

DG00796

Product (DG00796):

D00711<JP/US>

Efficacy

Anesthetic (intravenous), NMDA receptor antagonist

Comment

Phencyclidine derivative

Target

GRIN (NMDAR) [HSA:2902 2903 2904 2905 2906] [KO:K05208 K05209 K05210 K05211 K05212]

Pathway

hsa04020

Calcium signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04724

Glutamatergic synapse

Interaction

Structure map

map07235

N-Methyl-D-aspartic acid (NMDA) receptor antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01A ANESTHETICS, GENERAL
    N01AX Other general anesthetics
     N01AX03 Ketamine
      D00711  Ketamine hydrochloride (JP18/USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   111  General anesthetics
    1119  Others
     D00711  Ketamine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG02030  Anesthetics
   DG02027  General anesthetics
    DG00796  Ketamine
     D00711  Ketamine hydrochloride
  DG01498  NMDA receptor antagonist
   DG00796  Ketamine
    D00711  Ketamine hydrochloride
Target-based classification of drugs [BR:br08310]
Ion channels
  Ligand-gated ion channels
   Glutamate (ionotropic), NMDA
    GRIN (NMDAR)
     D00711  Ketamine hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00711  Ketamine hydrochloride
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG02030  Anesthetics
   DG02027  General anesthetics
    DG00796  Ketamine
  DG01498  NMDA receptor antagonist
   DG00796  Ketamine

Other DBs

CAS:

1867-66-9

PubChem:

7847776

ChEBI:

650657

LigandBox:

D00711

NIKKAJI:

J330.890A

KCF data

ATOM        17
            1   C1z C    25.6660  -16.9811
            2   C8y C    24.4548  -17.6859
            3   C5x C    27.0636  -17.0395
            4   C1x C    24.9498  -15.7756
            5   N1b N    26.3588  -18.1925
            6   C8y C    23.2376  -16.9870
            7   C8x C    24.4548  -19.0836
            8   C1x C    27.7508  -15.7523
            9   O5x O    27.7741  -18.1809
            10  C1x C    25.6427  -14.5585
            11  C1a C    25.6660  -19.4038
            12  C8x C    22.0262  -17.6859
            13  X   Cl   23.2493  -15.5893
            14  C8x C    23.2434  -19.7882
            15  C1x C    27.0403  -14.5411
            16  C8x C    22.0262  -19.0836
            17  X   Cl   30.1792  -16.9112
BOND        17
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 2
            6     2   7 1
            7     3   8 1
            8     3   9 2
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    6  13 1
            13    7  14 2
            14    8  15 1
            15   12  16 2
            16   10  15 1
            17   14  16 1