Dicyclomine hydrochloride


Entry
D00717                      Drug                                   
Name
Dicyclomine hydrochloride (JAN/USP);
Dicycloverine hydrochloride;
Bentyl (TN);
Urispas (TN)
Product
BENTYL (A-S Medication Solutions), BENTYL (Allergan)
  Generic
DICYCLOMINE HYDROCHLORIDE (A-S Medication Solutions), DICYCLOMINE HYDROCHLORIDE (A-S Medication Solutions), DICYCLOMINE HYDROCHLORIDE (A-S Medication Solutions), DICYCLOMINE HYDROCHLORIDE (A-S Medication Solutions), DICYCLOMINE (A-S Medication Solutions), DICYCLOMINE HYDROCHLORIDE (A-S Medication Solutions), DICYCLOMINE HYDROCHLORIDE (A-S Medication Solutions), DICYCLOMINE HYDROCHLORIDE (A-S Medication Solutions), DICYCLOMINE HYDROCHLORIDE (A-S Medication Solutions), DICYCLOMINE HYDROCHLORIDE (ATLANTIC BIOLOGICALS CORP.), DICYCLOMINE HYDROCHLORIDE (Actavis Pharma), DICYCLOMINE (Akorn), DICYCLOMINE HYDROCHLORIDE (American Health Packaging), DICYCLOMINE HYDROCHLORIDE (American Regent), DICYCLOMINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), DICYCLOMINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), DICYCLOMINE HYDROCHLORIDE (Bryant Ranch Prepack), DICYCLOMINE HYDROCHLORIDE (Bryant Ranch Prepack), DICYCLOMINE HYDROCHLORIDE (Bryant Ranch Prepack), DICYCLOMINE HYDROCHLORIDE (Bryant Ranch Prepack), DICYCLOMINE HYDROCHLORIDE (Bryant Ranch Prepack), DICYCLOMINE HYDROCHLORIDE (Bryant Ranch Prepack), DICYCLOMINE HYDROCHLORIDE (Bryant Ranch Prepack), DICYCLOMINE HYDROCHLORIDE (Bryant Ranch Prepack), DICYCLOMINE HYDROCHLORIDE (Camber Pharmaceuticals), DICYCLOMINE HYDROCHLORIDE (Cardinal Health), DICYCLOMINE HYDROCHLORIDE (Cardinal Health 107), DICYCLOMINE HYDROCHLORIDE (Clinical Solutions Wholesale), DICYCLOMINE HYDROCHLORIDE (DIRECT RX), DICYCLOMINE HYDROCHLORIDE (DIRECT RX), DICYCLOMINE HYDROCHLORIDE (Denton Pharma), DICYCLOMINE (Denton Pharma), DICYCLOMINE HYDROCHLORIDE (Denton Pharma), DICYCLOMINE HYDROCHLORIDE (Denton Pharma), DICYCLOMINE HYDROCHLORIDE (Denton Pharma), DICYCLOMINE HYDROCHLORIDE (Denton Pharma), DICYCLOMINE HYDROCHLORIDE (Direct_Rx), DICYCLOMINE HYDROCHLORIDE (Fosun Pharma USA), DICYCLOMINE HYDROCHLORIDE (Fresenius Kabi USA), DICYCLOMINE HYDROCHLORIDE (Gland Pharma Limited), DICYCLOMINE HYDROCHLORIDE (Golden State Medical Supply), DICYCLOMINE HYDROCHLORIDE (HF Acquisition Co LLC), DICYCLOMINE HYDROCHLORIDE (Hikma Pharmaceuticals USA), DICYCLOMINE HYDROCHLORIDE (Hikma Pharmaceuticals USA), DICYCLOMINE (Hikma Pharmaceuticals USA), DICYCLOMINE HYDROCHLORIDE (Hikma Pharmaceuticals USA), DICYCLOMINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), DICYCLOMINE HYDROCHLORIDE (Lannett Company), DICYCLOMINE HYDROCHLORIDE (Major Pharmaceuticals), DICYCLOMINE HYDROCHLORIDE (Marlex Pharmaceuticals), DICYCLOMINE HYDROCHLORIDE (Mylan Pharmaceuticals), DICYCLOMINE (NCS HealthCare of KY), DICYCLOMINE HCL (Nexus Pharmaceuticals), DICYCLOMINE HYDROCHLORIDE (Northwind Pharmaceuticals), DICYCLOMINE HYDROCHLORIDE (Novitium Pharma LLC), DICYCLOMINE HYDROCHLORIDE (NuCare Pharmaceuticals), DICYCLOMINE HYDROCHLORIDE (NuCare Pharmaceuticals), DICYCLOMINE HYDROCHLORIDE (NuCare Pharmaceuticals), DICYCLOMINE HYDROCHLORIDE (NuCare Pharmaceuticals), DICYCLOMINE HYDROCHLORIDE (NuCare Pharmaceuticals), DICYCLOMINE HYDROCHLORIDE (NuCare Pharmaceuticals), DICYCLOMINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), DICYCLOMINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), DICYCLOMINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), DICYCLOMINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), DICYCLOMINE HYDROCHLORIDE (Par Pharmaceutical), DICYCLOMINE HYDROCHLORIDE (Praxgen Pharmaceuticals LLC), DICYCLOMINE HYDROCHLORIDE (Preferred Pharmaceuticals), DICYCLOMINE HYDROCHLORIDE (Preferred Pharmaceuticals), DICYCLOMINE HYDROCHLORIDE (Preferred Pharmaceuticals), DICYCLOMINE HYDROCHLORIDE (Preferred Pharmaceuticals), DICYCLOMINE HYDROCHLORIDE (Proficient Rx LP), DICYCLOMINE HYDROCHLORIDE (Proficient Rx LP), DICYCLOMINE HYDROCHLORIDE (Proficient Rx LP), DICYCLOMINE HYDROCHLORIDE (Proficient Rx LP), DICYCLOMINE HYDROCHLORIDE (Quality Care Products), DICYCLOMINE (Quality Care Products), DICYCLOMINE HYDROCHLORIDE (REMEDYREPACK), DICYCLOMINE HYDROCHLORIDE (REMEDYREPACK), DICYCLOMINE HYDROCHLORIDE (REMEDYREPACK), DICYCLOMINE HYDROCHLORIDE (REMEDYREPACK), DICYCLOMINE HYDROCHLORIDE (REMEDYREPACK), DICYCLOMINE HYDROCHLORIDE (RPK Pharmaceuticals), DICYCLOMINE HYDROCHLORIDE (RPK Pharmaceuticals), DICYCLOMINE HYDROCHLORIDE (RedPharm Drug), DICYCLOMINE HYDROCHLORIDE (RedPharm Drug), DICYCLOMINE HYDROCHLORIDE (RedPharm Drug), DICYCLOMINE (RedPharm Drug), DICYCLOMINE HYDROCHLORIDE (RedPharm Drug), DICYCLOMINE HYDROCHLORIDE (Slate Run Pharmaceuticals), DICYCLOMINE HYDROCHLORIDE (St Mary's Medical Park Pharmacy), DICYCLOMINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), DICYCLOMINE HYDROCHLORIDE (Leucadia Pharmaceuticals)
Formula
C19H35NO2. HCl
Exact mass
345.2435
Mol weight
345.9476
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
Remark
ATC code: A03AA07
Chemical structure group: DG00032
Product (DG00032): D00717<US>
Product (mixture): D04364<JP>
Efficacy
Antispasmodic, Muscarinic acetylcholine receptor antagonist
  Disease
Functional bowel/irritable bowel syndrome [DS:H01615]
Target
CHRM1 [HSA:1128] [KO:K04129]
CHRM3 [HSA:1131] [KO:K04131]
CHRM2 [HSA:1129] [KO:K04130]
  Pathway
hsa04020  Calcium signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion
hsa04972  Pancreatic secretion
Interaction
Structure map
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A03 DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
   A03A DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
    A03AA Synthetic anticholinergics, esters with tertiary amino group
     A03AA07 Dicycloverine
      D00717  Dicyclomine hydrochloride (JAN/USP) <US>
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Antispasmodics, Gastrointestinal
   Dicyclomine
    D00717  Dicyclomine hydrochloride (JAN/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for digestive organs
  15 Stomach pain and cramp relievers
   D00717  Dicyclomine hydrochloride (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Dicycloverine
    D00717  Dicyclomine hydrochloride (JAN/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG00032  Dicycloverine
    D00717  Dicyclomine hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM1
     D00717  Dicyclomine hydrochloride (JAN/USP) <US>
    CHRM2
     D00717  Dicyclomine hydrochloride (JAN/USP) <US>
    CHRM3
     D00717  Dicyclomine hydrochloride (JAN/USP) <US>
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG00032  Dicycloverine
Other DBs
CAS: 67-92-5
PubChem: 7847782
ChEBI: 4515
LigandBox: D00717
NIKKAJI: J277.875K
KCF data

ATOM        23
            1   X   Cl   19.4100  -24.2269
            2   C7a C    22.9995  -21.0687
            3   O7a O    21.8052  -20.2963
            4   O6a O    22.9995  -22.4294
            5   C1b C    20.6584  -21.0687
            6   C1b C    19.4937  -20.3973
            7   N1c N    18.3113  -21.0687
            8   C1b C    17.1407  -20.3973
            9   C1b C    18.3113  -22.4294
            10  C1a C    15.9761  -21.0687
            11  C1a C    17.1407  -23.0949
            12  C1z C    24.2547  -20.3859
            13  C1y C    25.4975  -21.1457
            14  C1x C    25.4621  -22.5461
            15  C1x C    26.6758  -23.2883
            16  C1x C    27.9254  -22.6083
            17  C1x C    27.9607  -21.2079
            18  C1x C    26.7470  -20.4657
            19  C1x C    25.5110  -19.7020
            20  C1x C    25.5466  -18.2798
            21  C1x C    24.3328  -17.5378
            22  C1x C    23.0767  -18.2217
            23  C1x C    23.0409  -19.6439
BOND        23
            1     2   3 1
            2     2   4 2
            3     3   5 1
            4     5   6 1
            5     6   7 1
            6     7   8 1
            7     7   9 1
            8     8  10 1
            9     9  11 1
            10    2  12 1
            11   12  13 1
            12   13  14 1
            13   14  15 1
            14   15  16 1
            15   16  17 1
            16   17  18 1
            17   13  18 1
            18   12  19 1
            19   19  20 1
            20   20  21 1
            21   21  22 1
            22   22  23 1
            23   12  23 1