Methanthelinium bromide


Entry
D00721                      Drug                                   
Name
Methanthelinium bromide (INN);
Methantheline bromide;
Banthine (TN)
Formula
C21H26NO3. Br
Exact mass
419.1096
Mol weight
420.34
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
Remark
ATC code: A03AB07
Chemical structure group: DG00036
Efficacy
Antispasmodic, Muscarinic acetylcholine receptor antagonist
Comment
Quaternary ammonium compound
Target
CHRM [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
HRH2 [HSA:3274] [KO:K04150]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04971  Gastric acid secretion
Interaction
Structure map
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A03 DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
   A03A DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
    A03AB Synthetic anticholinergics, quaternary ammonium compounds
     A03AB07 Methantheline
      D00721  Methanthelinium bromide (INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG00036  Methantheline
    D00721  Methanthelinium bromide
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM
     D00721  Methanthelinium bromide (INN)
   Histamine
    HRH2
     D00721  Methanthelinium bromide (INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG00036  Methantheline
Other DBs
CAS: 53-46-3
PubChem: 7847786
ChEBI: 6818
LigandBox: D00721
NIKKAJI: J231.246H
KCF data

ATOM        26
            1   X   Br   34.1650   -9.6382 #-
            2   C8x C    27.3700  -13.6500
            3   C8x C    27.3700  -15.0500
            4   C8x C    28.5824  -15.7500
            5   C8y C    29.7949  -15.0500
            6   C8y C    29.7949  -13.6500
            7   C8x C    28.5824  -12.9500
            8   O2x O    31.0073  -15.7500
            9   C8y C    32.2197  -15.0500
            10  C8y C    32.2197  -13.6500
            11  C1y C    31.0073  -12.9500
            12  C8x C    33.4322  -15.7500
            13  C8x C    34.6446  -15.0500
            14  C8x C    34.6446  -13.6500
            15  C8x C    33.4322  -12.9500
            16  C7a C    31.0073  -11.5500
            17  O7a O    32.2218  -10.8488
            18  O6a O    29.7969  -10.8512
            19  C1b C    33.4183  -11.5398
            20  C1b C    34.6051  -10.8546
            21  N1d N    35.7966  -11.5428 #+
            22  C1b C    36.9860  -10.8561
            23  C1a C    35.7966  -12.9497
            24  C1a C    38.1762  -11.5435
            25  C1b C    35.7966  -10.1428
            26  C1a C    36.9859   -9.4560
BOND        27
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     5   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11    6  11 1
            12    9  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   10  15 2
            17   11  16 1
            18   16  17 1
            19   16  18 2
            20   17  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   21  23 1
            25   22  24 1
            26   21  25 1
            27   25  26 1