Entry

D00722                      Drug

Name

Oxybutynin chloride (USP);
Oxybutynin hydrochloride (JAN);
Ditropan (TN);
Gelnique (TN)

Product

GELNIQUE (Allergan), DITROPAN (Janssen Pharmaceuticals)

Generic

OXYBUTYNIN (A-S Medication Solutions), OXYBUTYNIN (A-S Medication Solutions), OXYBUTYNIN (Bryant Ranch Prepack), OXYBUTYNIN (Cadila Healthcare Limited), OXYBUTYNIN (NCS HealthCare of KY), OXYBUTYNIN (NCS HealthCare of KY), OXYBUTYNIN (Zydus Pharmaceuticals (USA)), OXYBUTYNIN CHLORIDE (A-S Medication Solutions), OXYBUTYNIN CHLORIDE (A-S Medication Solutions), OXYBUTYNIN CHLORIDE (A-S Medication Solutions), OXYBUTYNIN CHLORIDE (A-S Medication Solutions), OXYBUTYNIN CHLORIDE (A-S Medication Solutions), OXYBUTYNIN CHLORIDE (A-S Medication Solutions), OXYBUTYNIN CHLORIDE (A-S Medication Solutions), OXYBUTYNIN CHLORIDE (A-S Medication Solutions), OXYBUTYNIN CHLORIDE (Accord Healthcare), OXYBUTYNIN CHLORIDE (Advagen Pharma Limited), OXYBUTYNIN CHLORIDE (Ajanta Pharma USA), OXYBUTYNIN CHLORIDE (American Health Packaging), OXYBUTYNIN CHLORIDE (American Health Packaging), OXYBUTYNIN CHLORIDE (American Health Packaging), OXYBUTYNIN CHLORIDE (Amneal Pharmaceuticals LLC), OXYBUTYNIN CHLORIDE (Aphena Pharma Solutions - Tennessee), OXYBUTYNIN CHLORIDE (Aphena Pharma Solutions - Tennessee), OXYBUTYNIN CHLORIDE (Aphena Pharma Solutions - Tennessee), OXYBUTYNIN CHLORIDE (Aphena Pharma Solutions - Tennessee), OXYBUTYNIN CHLORIDE (Aphena Pharma Solutions - Tennessee), OXYBUTYNIN CHLORIDE (Aphena Pharma Solutions - Tennessee), OXYBUTYNIN CHLORIDE (Aphena Pharma Solutions - Tennessee), OXYBUTYNIN CHLORIDE (Atlantic Biologicals Corps), OXYBUTYNIN CHLORIDE (AvKARE), OXYBUTYNIN CHLORIDE (AvPAK), OXYBUTYNIN CHLORIDE (Bionpharma), OXYBUTYNIN CHLORIDE (Bryant Ranch Prepack), OXYBUTYNIN CHLORIDE (Bryant Ranch Prepack), OXYBUTYNIN CHLORIDE (Bryant Ranch Prepack), OXYBUTYNIN CHLORIDE (Bryant Ranch Prepack), OXYBUTYNIN CHLORIDE (Bryant Ranch Prepack), OXYBUTYNIN CHLORIDE (Bryant Ranch Prepack), OXYBUTYNIN CHLORIDE (Bryant Ranch Prepack), OXYBUTYNIN CHLORIDE (Bryant Ranch Prepack), OXYBUTYNIN CHLORIDE (Bryant Ranch Prepack), OXYBUTYNIN CHLORIDE (Cardinal Health), OXYBUTYNIN CHLORIDE (DIRECT RX), OXYBUTYNIN CHLORIDE (DOH CENTRAL PHARMACY), OXYBUTYNIN CHLORIDE (Denton Pharma), OXYBUTYNIN CHLORIDE (Eywa Pharma), OXYBUTYNIN CHLORIDE (Golden State Medical Supply), OXYBUTYNIN CHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), OXYBUTYNIN CHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), OXYBUTYNIN CHLORIDE (KVK-Tech), OXYBUTYNIN CHLORIDE (Lannett Company), OXYBUTYNIN CHLORIDE (Lannett Company), OXYBUTYNIN CHLORIDE (Leading Pharma), OXYBUTYNIN CHLORIDE (Major Pharmaceuticals), OXYBUTYNIN CHLORIDE (Major Pharmaceuticals), OXYBUTYNIN CHLORIDE (Major Pharmaceuticals), OXYBUTYNIN CHLORIDE (McKesson Corporation dba SKY Packaging), OXYBUTYNIN CHLORIDE (Morton Grove Pharmaceuticals), OXYBUTYNIN CHLORIDE (NCS HealthCare of KY), OXYBUTYNIN CHLORIDE (NCS HealthCare of KY), OXYBUTYNIN CHLORIDE (Novitium Pharma LLC), OXYBUTYNIN CHLORIDE (NuCare Pharmaceuticals), OXYBUTYNIN CHLORIDE (NuCare Pharmaceuticals), OXYBUTYNIN CHLORIDE (PD-Rx Pharmaceuticals), OXYBUTYNIN CHLORIDE (PD-Rx Pharmaceuticals), OXYBUTYNIN CHLORIDE (PD-Rx Pharmaceuticals), OXYBUTYNIN CHLORIDE (PD-Rx Pharmaceuticals), OXYBUTYNIN CHLORIDE (Par Pharmaceutical), OXYBUTYNIN CHLORIDE (Preferred Pharmaceuticals), OXYBUTYNIN CHLORIDE (Preferred Pharmaceuticals), OXYBUTYNIN CHLORIDE (Proficient Rx LP), OXYBUTYNIN CHLORIDE (Proficient Rx LP), OXYBUTYNIN CHLORIDE (REMEDYREPACK), OXYBUTYNIN CHLORIDE (REMEDYREPACK), OXYBUTYNIN CHLORIDE (REMEDYREPACK), OXYBUTYNIN CHLORIDE (REMEDYREPACK), OXYBUTYNIN CHLORIDE (REMEDYREPACK), OXYBUTYNIN CHLORIDE (REMEDYREPACK), OXYBUTYNIN CHLORIDE (REMEDYREPACK), OXYBUTYNIN CHLORIDE (REMEDYREPACK), OXYBUTYNIN CHLORIDE (RedPharm Drug), OXYBUTYNIN CHLORIDE (Rising Pharmaceuticals), OXYBUTYNIN CHLORIDE (Rising Pharmaceuticals), OXYBUTYNIN CHLORIDE (Strides Pharma Science Limited), OXYBUTYNIN CHLORIDE (Teva Pharmaceuticals USA), OXYBUTYNIN CHLORIDE (TruPharma LLC), OXYBUTYNIN CHLORIDE (Upsher-Smith Laboratories), OXYBUTYNIN CHLORIDE (direct rx)

Formula

C22H31NO3. HCl

Exact mass

393.2071

Mol weight

393.9474

Structure

Simcomp

Class

Neuropsychiatric agent
DG01491  Muscarinic cholinergic receptor antagonist
Metabolizing enzyme substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
DG02925  CYP3A5 substrate

Remark

Therapeutic category:

2590

ATC code:

G04BD04

Chemical structure group:

DG00478

Product (DG00478):

D00465<US> D00722<JP/US>

Efficacy

Antipollakisuria, Overactive bladder agent, Muscarinic acetylcholine receptor antagonist

Target

CHRM [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]

Pathway

hsa04020

Calcium signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04725

Cholinergic synapse

Metabolism

Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577]

Interaction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BD Urinary antispasmodics
     G04BD04 Oxybutynin
      D00722  Oxybutynin chloride (USP) <JP/US>
USP drug classification [BR:br08302]
Genitourinary Agents
  Antispasmodics, Urinary
   Oxybutynin
    D00722  Oxybutynin chloride (USP)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  25  Urogenital and anal organ agents
   259  Miscellaneous
    2590  Miscellaneous
     D00722  Oxybutynin chloride (USP); Oxybutynin hydrochloride (JAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG00478  Oxybutynin
    D00722  Oxybutynin chloride
Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00478  Oxybutynin
     D00722  Oxybutynin chloride
  DG02925  CYP3A5 substrate
   DG00478  Oxybutynin
    D00722  Oxybutynin chloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM
     D00722  Oxybutynin chloride (USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00722
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG00478  Oxybutynin
Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00478  Oxybutynin
  DG02925  CYP3A5 substrate
   DG00478  Oxybutynin

Other DBs

CAS:

1508-65-2

PubChem:

7847787

ChEBI:

7857

LigandBox:

D00722

NIKKAJI:

J244.850E

KCF data

ATOM        27
            1   X   Cl   40.2271  -21.8179
            2   C3b C    28.3117  -21.2592
            3   C1b C    29.5266  -21.9607
            4   O7a O    30.7417  -21.2592
            5   C7a C    31.9567  -21.9607
            6   C1d C    33.1717  -21.2592
            7   C8y C    34.3868  -21.9607
            8   C8x C    35.6018  -21.2592
            9   C8x C    36.8167  -21.9607
            10  C8x C    34.3868  -23.3637
            11  C8x C    35.6018  -24.0652
            12  C8x C    36.8167  -23.3637
            13  C1y C    33.1717  -19.8562
            14  C1x C    34.3718  -19.1632
            15  C1x C    34.3717  -17.7602
            16  C1x C    33.1567  -17.0588
            17  C1x C    31.9565  -17.7518
            18  C1x C    31.9566  -19.1548
            19  O1a O    34.3868  -20.5577
            20  O6a O    31.9567  -23.3637
            21  C3b C    27.0967  -20.5577
            22  C1b C    25.8816  -19.8562
            23  N1c N    24.6479  -20.5687
            24  C1b C    23.4400  -19.8715
            25  C1b C    24.6482  -21.9606
            26  C1a C    22.2552  -20.5558
            27  C1a C    23.4450  -22.6556
BOND        27
            1     2   3 1
            2     3   4 1
            3     4   5 1
            4     5   6 1
            5     6   7 1
            6     7   8 1
            7     8   9 2
            8     7  10 2
            9    10  11 1
            10   11  12 2
            11    9  12 1
            12    6  13 1
            13   13  14 1
            14   14  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   13  18 1
            19    6  19 1
            20    5  20 2
            21    2  21 3
            22   21  22 1
            23   22  23 1
            24   23  24 1
            25   23  25 1
            26   24  26 1
            27   25  27 1