Entry

D00724                      Drug

Name

Rabeprazole sodium (JP18/USP);
Aciphex (TN);
Pariet (TN)

Product

ACIPHEX (Eisai), ACIPHEX (Woodward Pharma Services LLC)

Generic

RABEPRAZOLE SODIUM (Amneal Pharmaceuticals LLC), RABEPRAZOLE SODIUM (A-S Medication Solutions), RABEPRAZOLE SODIUM (A-S Medication Solutions), RABEPRAZOLE SODIUM (A-S Medication Solutions), RABEPRAZOLE SODIUM (A-S Medication Solutions), RABEPRAZOLE SODIUM (A-S Medication Solutions), RABEPRAZOLE SODIUM (Advagen Pharma Limited), RABEPRAZOLE SODIUM (Advanced Rx Pharmacy of Tennessee), RABEPRAZOLE SODIUM (Advanced Rx Pharmacy of Tennessee), RABEPRAZOLE SODIUM (Ascend Laboratories), RABEPRAZOLE SODIUM (Asclemed USA), RABEPRAZOLE SODIUM (Asclemed USA), RABEPRAZOLE SODIUM (Aurobindo Pharma Limited), RABEPRAZOLE SODIUM (Bryant Ranch Prepack), RABEPRAZOLE SODIUM (Bryant Ranch Prepack), RABEPRAZOLE SODIUM (Bryant Ranch Prepack), RABEPRAZOLE SODIUM (Bryant Ranch Prepack), RABEPRAZOLE SODIUM (Bryant Ranch Prepack), RABEPRAZOLE SODIUM (DIRECT RX), RABEPRAZOLE SODIUM (DIRECT RX), RABEPRAZOLE SODIUM (Golden State Medical Supply), RABEPRAZOLE SODIUM (Lannett Company), RABEPRAZOLE SODIUM (Lupin Pharmaceuticals), RABEPRAZOLE SODIUM (Medsource Pharmaceuticals), RABEPRAZOLE SODIUM (Preferred Pharmaceuticals), RABEPRAZOLE SODIUM (Preferred Pharmaceuticals), RABEPRAZOLE SODIUM (Proficient Rx LP), RABEPRAZOLE SODIUM (Proficient Rx LP), RABEPRAZOLE SODIUM (Proficient Rx LP), RABEPRAZOLE SODIUM (Proficient Rx LP), RABEPRAZOLE SODIUM (Proficient Rx LP), RABEPRAZOLE SODIUM (Quality Care Products), RABEPRAZOLE SODIUM (REMEDYREPACK), RABEPRAZOLE SODIUM (REMEDYREPACK), RABEPRAZOLE SODIUM (REMEDYREPACK), RABEPRAZOLE SODIUM (St. Mary's Medical Park Pharmacy), RABEPRAZOLE SODIUM (St. Mary's Medical Park Pharmacy), RABEPRAZOLE SODIUM (Torrent Pharmaceuticals Limited), RABEPRAZOLE SODIUM (medsource pharmaceuticals), RABERPRAZOLE SODIUM D/R (DIRECT RX), RABERPRAZOLE SODIUM D/R (Direct_Rx)

Formula

C18H20N3O3S. Na

Exact mass

381.1123

Mol weight

381.4245

Structure

Simcomp

Class

Gastrointestinal agent
DG01975  Agents for peptic ulcer
  DG01646  Proton pump inhibitor (PPI)
Metabolizing enzyme substrate
DG01639  CYP2C19 substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate

Remark

Same as:

C07865

Therapeutic category:

2329

ATC code:

A02BC04

Chemical structure group:

DG00022

Product (DG00022):

D00724<JP/US>

Product (mixture):

D10519<JP> D10520<JP>

Efficacy

Antisecretory (gastric acid), Anti-ulcerative, Proton pump inhibitor

Disease

Erosive or ulcerative GERD [DS:H01602]
Duodenal ulcer [DS:H01634]
Helicobacter pylori eradication [DS:H00320]
Zollinger-Ellison syndrome [DS:H01522]

Comment

Benzimidazole derivative

Target

ATP4 [HSA:495 496] [KO:K01542 K01543]

Pathway

hsa04966

Collecting duct acid secretion

hsa04971

Gastric acid secretion

Metabolism

Enzyme: CYP2C19 [HSA:1557], CYP3A4 [HSA:1576]

Interaction

Structure map

map07038

Antiulcer drugs

map07233

Ion transporter inhibitors

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BC Proton pump inhibitors
     A02BC04 Rabeprazole
      D00724  Rabeprazole sodium (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Gastrointestinal Agents
  Proton Pump Inhibitors
   Rabeprazole
    D00724  Rabeprazole sodium (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2329  Others
     D00724  Rabeprazole sodium (JP18/USP)
Drug groups [BR:br08330]
Gastrointestinal agent
  DG01975  Agents for peptic ulcer
   DG01646  Proton pump inhibitor (PPI)
    DG00022  Rabeprazole
     D00724  Rabeprazole sodium
Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   DG00022  Rabeprazole
    D00724  Rabeprazole sodium
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00022  Rabeprazole
     D00724  Rabeprazole sodium
Drug classes [BR:br08332]
Gastrointestinal agent
  DG01646  Proton pump inhibitor (PPI)
   D00724  Rabeprazole sodium
Target-based classification of drugs [BR:br08310]
Enzymes
  Hydrolases (EC3)
   ATPase
    ATP4
     D00724  Rabeprazole sodium (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00724  Rabeprazole sodium
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D00724
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D00724
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00724
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
  D00724
Drug groups [BR:br08330]
Gastrointestinal agent
  DG01975  Agents for peptic ulcer
   DG01646  Proton pump inhibitor (PPI)
    DG00022  Rabeprazole
Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   DG00022  Rabeprazole
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00022  Rabeprazole

Other DBs

CAS:	117976-90-6

PubChem:

7847789

ChEBI:

8769

LigandBox:

D00724

NIKKAJI:

J561.822C

KCF data

ATOM        26
            1   Z   Na   14.9181  -21.7880 #+
            2   C8x C    11.7600  -23.5900
            3   C8x C    11.7600  -24.9900
            4   C8x C    12.9724  -25.6900
            5   C8y C    14.1849  -24.9900
            6   C8y C    14.1849  -23.5900
            7   C8x C    12.9724  -22.8900
            8   N5x N    15.5164  -25.4226
            9   C8y C    16.3393  -24.2900
            10  N4x N    15.5164  -23.1574 #-
            11  S4a S    17.7100  -24.2900
            12  C1b C    18.4100  -25.5024
            13  O3c O    18.4100  -23.0776
            14  C8y C    19.8098  -25.5024
            15  C8y C    20.5003  -26.6980
            16  C8y C    21.9003  -26.6978
            17  C8x C    22.6001  -25.4853
            18  C8x C    21.9097  -24.2898
            19  N5x N    20.5097  -24.2899
            20  C1a C    19.8149  -27.8852
            21  O2a O    22.5910  -27.8932
            22  C1b C    24.0096  -27.8932
            23  C1b C    24.6956  -29.0806
            24  C1b C    26.1097  -29.0806
            25  O2a O    26.7968  -30.2700
            26  C1a C    28.2097  -30.2699
BOND        27
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     5   8 1
            8     8   9 2
            9     9  10 1
            10    6  10 1
            11    9  11 1
            12   11  12 1
            13   11  13 2
            14   12  14 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   14  19 1
            21   15  20 1
            22   16  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1