| Entry |
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| Name | Methylprednisolone sodium succinate (JAN/USP); A-methapred (TN); Solu-medrol (TN) | ||||||||||
| Product | SOLU-MEDROL (A-S Medication Solutions), SOLU-MEDROL (Cardinal Health), SOLU-MEDROL (Cardinal Health 107), SOLU-MEDROL (Cardinal Health 107), SOLU-MEDROL (General Injectables & Vaccines), SOLU-MEDROL (General Injectables & Vaccines), SOLU-MEDROL (Henry Schein), SOLU-MEDROL (Henry Schein), SOLU-MEDROL (Medical Purchasing Solutions), SOLU-MEDROL (Medical Purchasing Solutions), SOLU-MEDROL (Medical Purchasing Solutions), SOLU-MEDROL (NuCare Pharmaceuticals), SOLU-MEDROL (Pharmacia & Upjohn Company LLC), SOLU-MEDROL (Pharmacia & Upjohn Company LLC), SOLU-MEDROL (REMEDYREPACK), SOLU-MEDROL (HF Acquisition Co. LLC), SOLU-MEDROL (HF Acquisition Co. LLC), SOLU-MEDROL(R) METHYLPREDNISOLONE SODIUM SUCCINAT (HF Acquisition Co LLC) | ||||||||||
| Generic | METHYLPREDNISOLONE SODIUM SUCCINATE (Amneal Pharmaceuticals LLC), METHYLPREDNISOLONE SODIUM SUCCINATE (GeneYork Pharmaceuticals Group LLC), METHYLPREDNISOLONE SODIUM SUCCINATE (Tianjin Kingyork Pharmaceuticals), METHYLPREDNISOLONE SODIUM SUCCINATE (AuroMedics Pharma LLC), METHYLPREDNISOLONE SODIUM SUCCINATE (Dr. Reddy's Laboratories), METHYLPREDNISOLONE SODIUM SUCCINATE (Fresenius Kabi USA), METHYLPREDNISOLONE SODIUM SUCCINATE (Hikma Pharmaceuticals USA), METHYLPREDNISOLONE SODIUM SUCCINATE (REMEDYREPACK) | ||||||||||
| Formula | C26H33O8. Na | ||||||||||
| Exact mass | 496.2073 | ||||||||||
| Mol weight | 496.5252 | ||||||||||
| Structure |  | ||||||||||
| Simcomp | |||||||||||
| Class | Anti-inflammatory DG01955 Corticosteroid DG02068 Glucocorticoid Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate | ||||||||||
| Remark |
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| Efficacy | Anti-inflammatory, Immunosuppressant, Glucocorticoid receptor agonist | ||||||||||
| Disease | Asthma [DS:H00079] Atopic dermatitis [DS:H01358] Contact dermatitis [DS:H01357] Allergic rhinitis [DS:H01360] Dermatitis herpetiformis [DS:H01362] Mycosis fungoides [DS:H01463] Pemphigus [DS:H01648] Erythema multiforme [DS:H01695] Stevens-Johnson syndrome [DS:H01694] Congenital adrenal hyperplasia [DS:H00216] Ulcerative colitis [DS:H01466] Acquired (autoimmune) hemolytic anemia [DS:H01585] Congenital (erythroid) hypoplastic anemia; Diamond-Blackfan anemia [DS:H00237] Idiopathic thrombocytopenic purpura [DS:H01240] Pure red cell aplasia [DS:H01586] Multiple sclerosis [DS:H01490] Ankylosing spondylitis [DS:H01674] Psoriatic arthritis [DS:H01507] Rheumatoid arthritis [DS:H00630] Juvenile idiopathic arthritis [DS:H01672] Dermatomyositis [DS:H01604] Temporal arteritis [DS:H01698] Polymyositis [DS:H01604] Systemic lupus erythematosus [DS:H00080] | ||||||||||
| Target | NR3C1 (GR) [HSA:2908] [KO:K05771] | ||||||||||
| Pathway |
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| Metabolism | Enzyme: CYP3A4 [HSA:1576] | ||||||||||
| Interaction | |||||||||||
| Structure map |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] D DERMATOLOGICALS D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS D07A CORTICOSTEROIDS, PLAIN D07AA Corticosteroids, weak (group I) D07AA01 Methylprednisolone D00751 Methylprednisolone sodium succinate (JAN/USP) <JP/US> D10 ANTI-ACNE PREPARATIONS D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE D10AA Corticosteroids, combinations for treatment of acne D10AA02 Methylprednisolone D00751 Methylprednisolone sodium succinate (JAN/USP) <JP/US> H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS H02 CORTICOSTEROIDS FOR SYSTEMIC USE H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN H02AB Glucocorticoids H02AB04 Methylprednisolone D00751 Methylprednisolone sodium succinate (JAN/USP) <JP/US> USP drug classification [BR:br08302] Dermatological Agents Dermatitis and Pruitus Agents Glucocorticoids, High Potency Methylprednisolone D00751 Methylprednisolone sodium succinate (JAN/USP) Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal) Methylprednisolone D00751 Methylprednisolone sodium succinate (JAN/USP) Inflammatory Bowel Disease Agents Glucocorticoids Methylprednisolone D00751 Methylprednisolone sodium succinate (JAN/USP) Therapeutic category of drugs in Japan [BR:br08301] 2 Agents affecting individual organs 24 Hormones 245 Adrenal hormone preparations 2456 Prednisolones D00751 Methylprednisolone sodium succinate (JAN/USP) Drug groups [BR:br08330] Anti-inflammatory DG01955 Corticosteroid DG02068 Glucocorticoid DG00410 Methylprednisolone D00751 Methylprednisolone sodium succinate Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate DG00410 Methylprednisolone D00751 Methylprednisolone sodium succinate Drug classes [BR:br08332] Anti-inflammatory DG01955 Corticosteroid D00751 Methylprednisolone sodium succinate Target-based classification of drugs [BR:br08310] Nuclear receptors Estrogen like receptors 3-Ketosteroid receptor NR3C1 (GR) D00751 Methylprednisolone sodium succinate (JAN/USP) <JP/US> Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D00751 Drug groups [BR:br08330] Anti-inflammatory DG01955 Corticosteroid DG02068 Glucocorticoid DG00410 Methylprednisolone Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate DG00410 Methylprednisolone | ||||||||||
| Other DBs |
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| KCF data | ATOM 35 1 C2x C 26.6700 -18.6900 2 C5x C 26.6700 -20.0900 3 C2x C 27.8600 -20.7900 4 C2y C 29.1200 -20.0900 5 C1z C 29.1200 -18.6900 6 C2x C 27.8600 -17.9900 7 C1y C 30.3100 -20.7900 8 C1x C 31.5000 -20.0900 9 C1y C 31.5000 -18.6900 10 C1y C 30.3100 -17.9900 11 C1y C 32.7600 -17.9900 12 C1z C 32.7600 -16.5900 13 C1x C 31.5000 -15.8900 14 C1y C 30.3100 -16.5900 15 C1x C 35.1400 -17.9900 16 C1x C 35.1400 -16.5900 17 C1z C 33.9500 -15.8900 18 O5x O 25.4800 -20.7900 19 C1a C 29.1200 -17.2900 20 O1a O 29.1200 -15.8900 21 C1a C 32.7600 -15.1900 22 C5a C 33.9500 -14.2100 23 C1a C 30.3100 -22.1900 24 O1a O 35.1400 -15.1900 25 C1b C 35.1400 -13.5100 26 O5a O 32.7600 -13.5100 27 O7a O 36.3300 -14.2100 28 C7a C 37.5200 -13.5100 29 C1b C 38.7100 -14.2100 30 O6a O 37.5200 -12.1100 31 C1b C 39.9281 -13.5199 32 C6a C 41.1095 -14.2150 33 O6a O 42.3149 -13.5320 #- 34 O6a O 41.0981 -15.6100 35 Z Na 43.7500 -13.5100 #+ BOND 37 1 1 2 1 2 2 3 1 3 3 4 2 4 4 5 1 5 5 6 1 6 1 6 2 7 4 7 1 8 7 8 1 9 8 9 1 10 9 10 1 11 5 10 1 12 9 11 1 13 11 12 1 14 12 13 1 15 13 14 1 16 10 14 1 17 11 15 1 18 15 16 1 19 16 17 1 20 12 17 1 21 2 18 2 22 5 19 1 #Up 23 14 20 1 #Up 24 12 21 1 #Up 25 17 22 1 #Up 26 7 23 1 #Down 27 17 24 1 #Down 28 22 25 1 29 22 26 2 30 25 27 1 31 27 28 1 32 28 29 1 33 28 30 2 34 29 31 1 35 31 32 1 36 32 33 1 37 32 34 2 |