| Entry |
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| Name | Tizanidine hydrochloride (JP18/USP); Zanaflex (TN) | ||||||||||
| Product | TIZANIDINE HYDROCHLORIDE (Actavis Pharma), TIZANIDINE HYDROCHLORIDE (Bryant Ranch Prepack), ZANAFLEX (Covis Pharma US) | ||||||||||
| Generic | TIZANDINE (DIRECT RX), TIZANDINE (DirectRX), TIZANDINE (Direct_Rx), TIZANDINE (Direct_Rx), TIZANDINE (Direct_Rx), TIZANIDINE (A-S Medication Solutions), TIZANIDINE (A-S Medication Solutions), TIZANIDINE (A-S Medication Solutions), TIZANIDINE (A-S Medication Solutions), TIZANIDINE (A-S Medication Solutions), TIZANIDINE (American Health Packaging), TIZANIDINE (Aphena Pharma Solutions - Tennessee), TIZANIDINE (Aphena Pharma Solutions - Tennessee), TIZANIDINE (Aphena Pharma Solutions - Tennessee), TIZANIDINE (Aphena Pharma Solutions - Tennessee), TIZANIDINE (Aphena Pharma Solutions - Tennessee), TIZANIDINE (Aphena Pharma Solutions - Tennessee), TIZANIDINE (Apotex Corp.), TIZANIDINE (Ascend Laboratories), TIZANIDINE (Asclemed USA), TIZANIDINE (AvKARE), TIZANIDINE (AvPAK), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Bryant Ranch Prepack), TIZANIDINE (Cadila Healthcare Limited), TIZANIDINE (Cardinal Health), TIZANIDINE (Denton Pharma), TIZANIDINE (Denton Pharma), TIZANIDINE (Direct_Rx), TIZANIDINE (Direct_Rx), TIZANIDINE (Dr. Reddy's Laboratories Limited), TIZANIDINE (Major Pharmaceuticals), TIZANIDINE (Major Pharmaceuticals), TIZANIDINE (NCS HealthCare of KY), TIZANIDINE (NorthStar Rx LLC), TIZANIDINE (NuCare Pharmaceuticals), TIZANIDINE (NuCare Pharmaceuticals), TIZANIDINE (NuCare Pharmaceuticals), TIZANIDINE (PD-Rx Pharmaceuticals), TIZANIDINE (PD-Rx Pharmaceuticals), TIZANIDINE (Preferred Pharmaceuticals), TIZANIDINE (Preferred Pharmaceuticals), TIZANIDINE (Preferred Pharmaceuticals), TIZANIDINE (Preferred Pharmaceuticals), TIZANIDINE (Preferred Pharmaceuticals), TIZANIDINE (Preferred Pharmaceuticals), TIZANIDINE (Proficient Rx LP), TIZANIDINE (Proficient Rx LP), TIZANIDINE (Proficient Rx LP), TIZANIDINE (Proficient Rx LP), TIZANIDINE (Proficient Rx LP), TIZANIDINE (Proficient Rx LP), TIZANIDINE (Quality Care Products), TIZANIDINE (REMEDYREPACK), TIZANIDINE (REMEDYREPACK), TIZANIDINE (REMEDYREPACK), TIZANIDINE (REMEDYREPACK), TIZANIDINE (REMEDYREPACK), TIZANIDINE (REMEDYREPACK), TIZANIDINE (RPK Pharmaceuticals), TIZANIDINE (RedPharm Drug), TIZANIDINE (RedPharm Drug), TIZANIDINE (RedPharm Drug), TIZANIDINE (RedPharm Drug), TIZANIDINE (St Mary's Medical Park Pharmacy), TIZANIDINE (St. Mary's Medical Park Pharmacy), TIZANIDINE (St. Mary's Medical Park Pharmacy), TIZANIDINE (St. Mary's Medical Park Pharmacy), TIZANIDINE (St. Mary's Medical Park Pharmacy), TIZANIDINE (St. Mary's Medical Park Pharmacy), TIZANIDINE (St. Mary's Medical Park Pharmacy), TIZANIDINE (Sun Pharmaceutical Industries), TIZANIDINE (Unichem Pharmaceuticals (USA)), TIZANIDINE (Unit Dose Services), TIZANIDINE (Viona Pharmaceuticals), TIZANIDINE HCL (ADVANCED RX PHARMACY OF TENNESSEE), TIZANIDINE HCL (Advanced Rx Pharmacy of Tennessee), TIZANIDINE HCL (Advanced Rx Pharmacy of Tennessee), TIZANIDINE HCL (Advanced Rx Pharmacy of Tennessee), TIZANIDINE HCL (Advanced Rx Pharmacy of Tennessee), TIZANIDINE HCL (Advanced Rx Pharmacy of Tennessee), TIZANIDINE HYDROCHLORIDE (Advagen Pharma Limited), TIZANIDINE HYDROCHLORIDE (Alembic Pharmaceuticals), TIZANIDINE HYDROCHLORIDE (Alembic Pharmaceuticals Limited), TIZANIDINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), TIZANIDINE HYDROCHLORIDE (Apotex Corp.), TIZANIDINE HYDROCHLORIDE (Aurobindo Pharma Limited), TIZANIDINE HYDROCHLORIDE (AvKARE), TIZANIDINE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDINE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDINE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDINE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDINE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDINE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDINE HYDROCHLORIDE (Cadila Healthcare Limited), TIZANIDINE HYDROCHLORIDE (Cadila Pharmaceuticals Limited), TIZANIDINE HYDROCHLORIDE (Eon Labs), TIZANIDINE HYDROCHLORIDE (Ingenus Pharmaceuticals), TIZANIDINE HYDROCHLORIDE (Jubilant Cadista Pharmaceuticals), TIZANIDINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), TIZANIDINE HYDROCHLORIDE (Modavar Pharmaceuticals LLC), TIZANIDINE HYDROCHLORIDE (Nivagen Pharmaceuticals), TIZANIDINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), TIZANIDINE HYDROCHLORIDE (Quality Care Products), TIZANIDINE HYDROCHLORIDE (Quality Care Products), TIZANIDINE HYDROCHLORIDE (TIZANIDINE HYDROCHLORIDE), TIZANIDINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), TIZANIDINE HYDROCHLORIDE (medsource pharmaceuticals), TIZANIDNE HYDROCHLORIDE (Ascend Laboratories), TIZANIDNE HYDROCHLORIDE (Asclemed USA), TIZANIDNE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDNE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDNE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDNE HYDROCHLORIDE (Bryant Ranch Prepack), TIZANIDNE HYDROCHLORIDE (Preferred Pharmaceuticals), TIZANIDNE HYDROCHLORIDE (RedPharm Drug) | ||||||||||
| Formula | C9H8ClN5S. HCl | ||||||||||
| Exact mass | 288.9956 | ||||||||||
| Mol weight | 290.1723 | ||||||||||
| Structure |  | ||||||||||
| Simcomp | |||||||||||
| Class | Cardiovascular agent DG01456 Adrenergic receptor agonist DG01450 alpha-Adrenergic receptor agonist DG01449 alpha2-Adrenergic receptor agonist Musculo-skeletal system agent DG02029 Muscle relaxant DG01974 Centrally acting muscle relaxant Metabolizing enzyme substrate DG01892 CYP1A2 substrate | ||||||||||
| Remark |
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| Efficacy | Antispasmodic, Muscle relaxant, alpha2-Adrenergic receptor agonist | ||||||||||
| Comment | Imidazoline derivative | ||||||||||
| Target | ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140] | ||||||||||
| Pathway |
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| Metabolism | Enzyme: CYP1A2 [HSA:1544] | ||||||||||
| Interaction | |||||||||||
| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] M MUSCULO-SKELETAL SYSTEM M03 MUSCLE RELAXANTS M03B MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS M03BX Other centrally acting agents M03BX02 Tizanidine D00776 Tizanidine hydrochloride (JP18/USP) <JP/US> USP drug classification [BR:br08302] Antispasticity Agents Tizanidine D00776 Tizanidine hydrochloride (JP18/USP) Therapeutic category of drugs in Japan [BR:br08301] 1 Agents affecting nervous system and sensory organs 12 Agents affecting peripheral nervous system 124 Antispasmodics 1249 Others D00776 Tizanidine hydrochloride (JP18/USP) Drug groups [BR:br08330] Cardiovascular agent DG01456 Adrenergic receptor agonist DG01450 alpha-Adrenergic receptor agonist DG01449 alpha2-Adrenergic receptor agonist DG00773 Tizanidine D00776 Tizanidine hydrochloride Musculo-skeletal system agent DG02029 Muscle relaxant DG01974 Centrally acting muscle relaxant DG00773 Tizanidine D00776 Tizanidine hydrochloride Metabolizing enzyme substrate DG01892 CYP1A2 substrate DG00773 Tizanidine D00776 Tizanidine hydrochloride Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Rhodopsin family Adrenaline ADRA2 D00776 Tizanidine hydrochloride (JP18/USP) <JP/US> Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D00776 Tizanidine hydrochloride Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D00776 Drug groups [BR:br08330] Cardiovascular agent DG01456 Adrenergic receptor agonist DG01450 alpha-Adrenergic receptor agonist DG01449 alpha2-Adrenergic receptor agonist DG00773 Tizanidine Musculo-skeletal system agent DG02029 Muscle relaxant DG01974 Centrally acting muscle relaxant DG00773 Tizanidine Metabolizing enzyme substrate DG01892 CYP1A2 substrate DG00773 Tizanidine | ||||||||||
| Other DBs |
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| KCF data | ATOM 17 1 C8y C 29.0260 -18.0837 2 C8y C 29.0260 -16.6827 3 C8y C 27.8120 -18.7958 4 N5x N 30.0708 -19.0235 5 N1b N 30.2343 -15.9882 6 C8y C 27.8120 -15.9823 7 C8x C 26.5921 -18.0837 8 N5x N 28.1155 -20.1617 9 S2x S 29.5105 -20.3018 10 C2y C 31.4426 -16.6944 11 C8x C 26.5921 -16.6827 12 X Cl 27.8003 -14.5816 13 N1x N 32.7500 -16.2424 14 N2x N 31.4535 -18.0910 15 C1x C 33.5919 -17.3543 16 C1x C 32.7903 -18.4961 17 X Cl 36.7067 -17.3950 BOND 18 1 1 2 1 2 1 3 1 3 1 4 2 4 2 5 1 5 2 6 2 6 3 7 1 7 3 8 2 8 4 9 1 9 5 10 1 10 6 11 1 11 6 12 1 12 10 13 1 13 10 14 2 14 13 15 1 15 14 16 1 16 7 11 2 17 8 9 1 18 15 16 1 |