Benztropine mesylate

Entry

D00778                      Drug

Name

Benztropine mesylate (USP);
Benztropine mesilate (JAN);
Cogentin (TN)

Product

Generic

BENZTROPINE MESYLATE (Cipla USA), BENZTROPINE MESYLATE (A-S Medication Solutions), BENZTROPINE MESYLATE (A-S Medication Solutions), BENZTROPINE MESYLATE (A-S Medication Solutions), BENZTROPINE MESYLATE (A-S Medication Solutions), BENZTROPINE MESYLATE (A-S Medication Solutions), BENZTROPINE MESYLATE (American Health Packaging), BENZTROPINE MESYLATE (Aphena Pharma Solutions - Tennessee), BENZTROPINE MESYLATE (Aphena Pharma Solutions - Tennnessee), BENZTROPINE MESYLATE (Bayshore Pharmaceuticals LLC (NJ)), BENZTROPINE MESYLATE (Bryant Ranch Prepack), BENZTROPINE MESYLATE (Bryant Ranch Prepack), BENZTROPINE MESYLATE (Bryant Ranch Prepack), BENZTROPINE MESYLATE (Bryant Ranch Prepack), BENZTROPINE MESYLATE (Bryant Ranch Prepack), BENZTROPINE MESYLATE (Bryant Ranch Prepack), BENZTROPINE MESYLATE (Cardinal Health), BENZTROPINE MESYLATE (Chartwell RX), BENZTROPINE MESYLATE (Clinical Solutions Wholesale), BENZTROPINE MESYLATE (DIRECT RX), BENZTROPINE MESYLATE (Fresenius Kabi USA), BENZTROPINE MESYLATE (Hikma Pharmaceuticals USA), BENZTROPINE MESYLATE (Hikma Pharmaceuticals USA), BENZTROPINE MESYLATE (Leading Pharma), BENZTROPINE MESYLATE (Major Pharmaceuticals), BENZTROPINE MESYLATE (NCS HealthCare of KY), BENZTROPINE MESYLATE (Navinta LLC), BENZTROPINE MESYLATE (Par Pharmaceutical), BENZTROPINE MESYLATE (Par Pharmaceutical), BENZTROPINE MESYLATE (Proficient Rx LP), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (Zydus Pharmaceuticals USA)

Formula

C21H25NO. CH4SO3

Exact mass

403.1817

Mol weight

403.535

Structure

Simcomp

Class

Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
DG01745 Anticholinergic antiparkinson agent

Remark

ATC code:

N04AC01

Chemical structure group:

DG00859

Product (DG00859):

D00778<US>

Efficacy

Antiparkinsonian, Muscarinic acetylcholine receptor antagonist

Disease

Parkinsonism [DS:H01600]

Comment

Tropane derivative

Target

CHRM [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04725

Cholinergic synapse

Interaction

Structure map

map07057

Antiparkinsonian agents

map07220

Cholinergic and anticholinergic drugs

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04A ANTICHOLINERGIC AGENTS
    N04AC Ethers of tropine or tropine derivatives
     N04AC01 Benzatropine
      D00778  Benztropine mesylate (USP) <US>
USP drug classification [BR:br08302]
Antiparkinson Agents
  Anticholinergics
   Benztropine
    D00778  Benztropine mesylate (USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG01745  Anticholinergic antiparkinson agent
    DG00859  Benzatropine
     D00778  Benztropine mesylate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM
     D00778  Benztropine mesylate (USP) <US>
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG01745  Anticholinergic antiparkinson agent
    DG00859  Benzatropine

Other DBs

CAS:

132-17-2

PubChem:

7847843

ChEBI:

3049

LigandBox:

D00778

NIKKAJI:

J237.902C

KCF data

ATOM        28
            1   S4a S    33.2140  -18.8297
            2   C1a C    31.8828  -18.8243
            3   O1d O    34.5508  -18.8297
            4   O1d O    33.2084  -17.4986
            5   O1d O    33.2084  -20.1610
            6   C1x C    20.7530  -17.8020
            7   C1x C    21.0706  -16.6678
            8   C1y C    21.8872  -17.5298
            9   C1y C    22.2047  -16.3956
            10  N1y N    20.9799  -15.1254
            11  C1x C    23.7018  -17.5298
            12  C1x C    23.4296  -16.3956
            13  C1y C    24.6999  -18.0742
            14  O2a O    25.7433  -18.9362
            15  C1a C    20.2548  -13.9791
            16  C1c C    27.1433  -18.9362
            17  C8y C    27.8622  -20.1811
            18  C8y C    27.8331  -17.7424
            19  C8x C    29.2596  -17.7435
            20  C8x C    29.9605  -16.5316
            21  C8x C    29.2614  -15.3186
            22  C8x C    27.8349  -15.3175
            23  C8x C    27.1340  -16.5294
            24  C8x C    27.1708  -21.3786
            25  C8x C    27.8707  -22.5911
            26  C8x C    29.2707  -22.5912
            27  C8x C    29.9621  -21.3937
            28  C8x C    29.2622  -20.1812
BOND        30
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     1   5 2
            5     6   7 1
            6     6   8 1
            7     7   9 1
            8     8  10 1
            9     8  11 1
            10    9  12 1
            11   11  13 1
            12   13  14 1 #Down
            13    9  10 1
            14   12  13 1
            15   10  15 1
            16   14  16 1
            17   16  17 1
            18   16  18 1
            19   18  19 2
            20   19  20 1
            21   20  21 2
            22   21  22 1
            23   22  23 2
            24   18  23 1
            25   17  24 2
            26   24  25 1
            27   25  26 2
            28   26  27 1
            29   27  28 2
            30   17  28 1