Entry

D00784                      Drug

Name

Ropinirole hydrochloride (JAN/USP);
Requip (TN)

Product

Generic

ROPINIROLE (A-S Medication Solutions), ROPINIROLE (A-S Medication Solutions), ROPINIROLE (A-S Medication Solutions), ROPINIROLE (A-S Medication Solutions), ROPINIROLE (Accord Healthcare), ROPINIROLE (Actavis Pharma), ROPINIROLE (Alembic Pharmaceuticals), ROPINIROLE (Alembic Pharmaceuticals Limited), ROPINIROLE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (Bryant Ranch Prepack), ROPINIROLE (DIRECT RX), ROPINIROLE (Direct_Rx), ROPINIROLE (Dr. Reddys Laboratories Limited), ROPINIROLE (Glenmark Pharmaceuticals), ROPINIROLE HYDROCHLORIDE (Golden State Medical Supply), ROPINIROLE (Marlex Pharmaceuticals), ROPINIROLE (Mylan Pharmaceuticals), ROPINIROLE (REMEDYREPACK), ROPINIROLE (REMEDYREPACK), ROPINIROLE (REMEDYREPACK), ROPINIROLE (REMEDYREPACK), ROPINIROLE (Sandoz), ROPINIROLE (Solco Healthcare US), ROPINIROLE HYDROCHLORIDE (A-S Medication Solutions), ROPINIROLE HYDROCHLORIDE (A-S Medication Solutions), ROPINIROLE HYDROCHLORIDE (A-S Medication Solutions), ROPINIROLE HYDROCHLORIDE (Alembic Pharmaceuticals), ROPINIROLE HYDROCHLORIDE (Alembic Pharmaceuticals Limited), ROPINIROLE HYDROCHLORIDE (American Health Packaging), ROPINIROLE HYDROCHLORIDE (AvPAK), ROPINIROLE HYDROCHLORIDE (Bryant Ranch Prepack), ROPINIROLE HYDROCHLORIDE (Bryant Ranch Prepack), ROPINIROLE HYDROCHLORIDE (Bryant Ranch Prepack), ROPINIROLE HYDROCHLORIDE (Bryant Ranch Prepack), ROPINIROLE HYDROCHLORIDE (Bryant Ranch Prepack), ROPINIROLE HYDROCHLORIDE (Cadila Healthcare Limited), ROPINIROLE HYDROCHLORIDE (Cardinal Health), ROPINIROLE HYDROCHLORIDE (Direct_Rx), ROPINIROLE HYDROCHLORIDE (Major Pharmaceuticals), ROPINIROLE HYDROCHLORIDE (NCS HealthCare of KY), ROPINIROLE HYDROCHLORIDE (Northwind Pharmaceuticals), ROPINIROLE HYDROCHLORIDE (REMEDYREPACK), ROPINIROLE HYDROCHLORIDE (SOLCO HEALTHCARE US), ROPINIROLE HYDROCHLORIDE (SOLCO HEALTHCARE US)

Formula

C16H24N2O. HCl

Exact mass

296.1655

Mol weight

296.8355

Structure

Simcomp

Class

Neuropsychiatric agent
DG01472  Dopamine agonist
  DG01468  Dopamine D2-receptor agonist
DG01967  Antiparkinson agent
Metabolizing enzyme substrate
DG01892  CYP1A2 substrate

Remark

Therapeutic category:

1169

ATC code:

N04BC04

Chemical structure group:

DG00862

Product (DG00862):

D00784<JP/US>

Efficacy

Antiparkinsonian, Dopamine receptor agonist

Disease

Parkinson disease [DS:H00057]
Restless legs syndrome [DS:H01597]

Target

DRD2 [HSA:1813] [KO:K04145]
DRD3 [HSA:1814] [KO:K04146]
DRD4 [HSA:1815] [KO:K04147]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04728

Dopaminergic synapse

hsa05012

Parkinson disease

Metabolism

Enzyme: CYP1A2 [HSA:1544]

Interaction

Structure map

map07057

Antiparkinsonian agents

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04B DOPAMINERGIC AGENTS
    N04BC Dopamine agonists
     N04BC04 Ropinirole
      D00784  Ropinirole hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Antiparkinson Agents
  Dopamine Agonists
   Ropinirole
    D00784  Ropinirole hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   116  Antiparkinsonian agents
    1169  Others
     D00784  Ropinirole hydrochloride (JAN/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01472  Dopamine agonist
   DG01468  Dopamine D2-receptor agonist
    DG00862  Ropinirole
     D00784  Ropinirole hydrochloride
  DG01967  Antiparkinson agent
   DG00862  Ropinirole
    D00784  Ropinirole hydrochloride
Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00862  Ropinirole
    D00784  Ropinirole hydrochloride
Drug classes [BR:br08332]
Neuropsychiatric agent
  DG01967  Antiparkinson agent
   D00784  Ropinirole hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D00784  Ropinirole hydrochloride (JAN/USP) <JP/US>
    DRD3
     D00784  Ropinirole hydrochloride (JAN/USP) <JP/US>
    DRD4
     D00784  Ropinirole hydrochloride (JAN/USP) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D00784
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00784
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01472  Dopamine agonist
   DG01468  Dopamine D2-receptor agonist
    DG00862  Ropinirole
  DG01967  Antiparkinson agent
   DG00862  Ropinirole
Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00862  Ropinirole

Other DBs

CAS:	91374-20-8

PubChem:

7847849

ChEBI:

8889

LigandBox:

D00784

KCF data

ATOM        20
            1   C8y C    26.1291  -19.3087
            2   C8y C    24.9204  -18.6139
            3   C8y C    26.1291  -20.7101
            4   C1x C    27.4604  -18.8825
            5   C1b C    24.9204  -17.2007
            6   C8x C    23.6999  -19.3087
            7   N1x N    27.4604  -21.1423
            8   C8x C    24.9204  -21.4225
            9   C5x C    28.2721  -20.0152
            10  C1b C    23.7059  -16.5058
            11  C8x C    23.6999  -20.7159
            12  O5x O    29.6735  -20.0152
            13  N1c N    22.4912  -17.2007
            14  C1b C    21.2767  -16.5058
            15  C1b C    22.4912  -18.5963
            16  C1b C    20.0620  -17.2007
            17  C1b C    21.2767  -19.2970
            18  C1a C    18.8533  -16.5058
            19  C1a C    21.2767  -20.6925
            20  X   Cl   32.6749  -19.9798
BOND        20
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    9  12 2
            12   10  13 1
            13   13  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17   16  18 1
            18   17  19 1
            19    7   9 1
            20    8  11 2