Entry

D00787                      Drug

Name

Trihexyphenidyl hydrochloride (JP18/USP);
Artane (TN)

Product

Generic

TRIHEXYPHENIDYL HYDROCHLORIDE (A-S Medication Solutions), TRIHEXYPHENIDYL HYDROCHLORIDE (A-S Medication Solutions), TRIHEXYPHENIDYL HYDROCHLORIDE (Actavis Pharma), TRIHEXYPHENIDYL HYDROCHLORIDE (Akorn), TRIHEXYPHENIDYL HYDROCHLORIDE (Bionpharma), TRIHEXYPHENIDYL HYDROCHLORIDE (Golden State Medical Supply), TRIHEXYPHENIDYL HYDROCHLORIDE (Natco Pharma Limited), TRIHEXYPHENIDYL HYDROCHLORIDE (Novitium Pharma LLC), TRIHEXYPHENIDYL HYDROCHLORIDE (Pharmaceutical Associates), TRIHEXYPHENIDYL HYDROCHLORIDE (REMEDYREPACK), TRIHEXYPHENIDYL HYDROCHLORIDE (REMEDYREPACK), TRIHEXYPHENIDYL HYDROCHLORIDE (REMEDYREPACK), TRIHEXYPHENIDYL HYDROCHLORIDE (REMEDYREPACK), TRIHEXYPHENIDYL HYDROCHLORIDE (REMEDYREPACK), TRIHEXYPHENIDYL HYDROCHLORIDE (REMEDYREPACK), TRIHEXYPHENIDYL HYDROCHLORIDE (REMEDYREPACK), TRIHEXYPHENIDYL HYDROCHLORIDE (REMEDYREPACK), TRIHEXYPHENIDYL HYDROCHLORIDE (REMEDYREPACK), TRIHEXYPHENIDYL HYDROCHLORIDE (REMEDYREPACK), TRIHEXYPHENIDYL HYDROCHLORIDE (Rising Pharmaceuticals)

Formula

C20H31NO. HCl

Exact mass

337.2172

Mol weight

337.9272

Structure

Simcomp

Class

Neuropsychiatric agent
DG01491  Muscarinic cholinergic receptor antagonist
  DG01745  Anticholinergic antiparkinson agent
DG01967  Antiparkinson agent

Remark

Therapeutic category:

1169

ATC code:

N04AA01

Chemical structure group:

DG00851

Product (DG00851):

D00787<JP/US>

Efficacy

Antiparkinsonian, Muscarinic acetylcholine receptor antagonist

Disease

Parkinsonism [DS:H01600]

Target

CHRM [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04725

Cholinergic synapse

Interaction

Structure map

map07057

Antiparkinsonian agents

map07220

Cholinergic and anticholinergic drugs

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04A ANTICHOLINERGIC AGENTS
    N04AA Tertiary amines
     N04AA01 Trihexyphenidyl
      D00787  Trihexyphenidyl hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Antiparkinson Agents
  Anticholinergics
   Trihexyphenidyl
    D00787  Trihexyphenidyl hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   116  Antiparkinsonian agents
    1169  Others
     D00787  Trihexyphenidyl hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG01745  Anticholinergic antiparkinson agent
    DG00851  Trihexyphenidyl
     D00787  Trihexyphenidyl hydrochloride
  DG01967  Antiparkinson agent
   DG00851  Trihexyphenidyl
    D00787  Trihexyphenidyl hydrochloride
Drug classes [BR:br08332]
Neuropsychiatric agent
  DG01967  Antiparkinson agent
   D00787  Trihexyphenidyl hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM
     D00787  Trihexyphenidyl hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00787  Trihexyphenidyl hydrochloride
  D00787  Trihexyphenidyl hydrochloride tablets
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG01745  Anticholinergic antiparkinson agent
    DG00851  Trihexyphenidyl
  DG01967  Antiparkinson agent
   DG00851  Trihexyphenidyl

Other DBs

CAS:

52-49-3

PubChem:

7847852

ChEBI:

9721

LigandBox:

D00787

NIKKAJI:

J231.242E

KCF data

ATOM        23
            1   X   Cl   29.1405  -19.5417
            2   C8x C    27.3218  -23.9734
            3   C8x C    28.5397  -23.2839
            4   C8x C    28.5626  -21.9039
            5   C8x C    27.3331  -21.1525
            6   C8y C    26.1151  -21.8421
            7   C8x C    26.1268  -23.2830
            8   C1x C    26.1608  -19.0821
            9   C1y C    24.9429  -19.7716
            10  C1d C    24.9201  -21.1516
            11  C1x C    26.1492  -17.6412
            12  C1x C    24.9542  -16.9507
            13  C1x C    23.7362  -17.6402
            14  C1x C    23.7134  -19.0202
            15  C1b C    23.7021  -21.8411
            16  C1b C    22.5071  -21.1507
            17  N1y N    21.2892  -21.8402
            18  C1x C    20.0831  -21.1302
            19  C1x C    18.8651  -21.8198
            20  C1x C    18.8533  -23.2193
            21  C1x C    20.0594  -23.9292
            22  C1x C    21.2773  -23.2397
            23  O1a O    26.1325  -20.4516
BOND        24
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     8   9 1
            8     9  10 1
            9     6  10 1
            10    8  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14    9  14 1
            15   10  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   20  21 1
            22   21  22 1
            23   17  22 1
            24   10  23 1