Desipramine hydrochloride


Entry
D00812                      Drug                                   
Name
Desipramine hydrochloride (JAN/USP);
Norpramin (TN)
Product
NORPRAMIN (Validus Pharmaceuticals LLC)
  Generic
DESIPRAMINE HYDROCHLORIDE (Amneal Pharmaceuticals NY LLC), DESIPRAMINE HYDROCHLORIDE (Bryant Ranch Prepack), DESIPRAMINE HYDROCHLORIDE (Actavis Pharma), DESIPRAMINE HYDROCHLORIDE (Alembic Pharmaceuticals), DESIPRAMINE HYDROCHLORIDE (Alembic Pharmaceuticals Limited), DESIPRAMINE HYDROCHLORIDE (Bryant Ranch Prepack), DESIPRAMINE HYDROCHLORIDE (Bryant Ranch Prepack), DESIPRAMINE HYDROCHLORIDE (DIRECT RX), DESIPRAMINE HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), DESIPRAMINE HYDROCHLORIDE (Ingenus Pharmaceuticals), DESIPRAMINE HYDROCHLORIDE (Preferred Pharmaceuticals), DESIPRAMINE HYDROCHLORIDE (Sandoz)
Formula
C18H22N2. HCl
Exact mass
302.155
Mol weight
302.8416
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01730  Non-selective monoamine reuptake inhibitor
 DG01728  Tricyclic antidepressant
Remark
ATC code: N06AA01
Chemical structure group: DG00927
Product (DG00927): D00812<US>
Efficacy
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI)
  Disease
Depression [DS:H01646]
Target
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04726  Serotonergic synapse
Interaction
Structure map
map07027  Antidepressants
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AA Non-selective monoamine reuptake inhibitors
     N06AA01 Desipramine
      D00812  Desipramine hydrochloride (JAN/USP) <US>
USP drug classification [BR:br08302]
 Antidepressants
  Tricyclics
   Desipramine
    D00812  Desipramine hydrochloride (JAN/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01730  Non-selective monoamine reuptake inhibitor
   DG00927  Desipramine
    D00812  Desipramine hydrochloride
  DG01728  Tricyclic antidepressant
   DG00927  Desipramine
    D00812  Desipramine hydrochloride
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG01730  Non-selective monoamine reuptake inhibitor
   D00812  Desipramine hydrochloride
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D00812  Desipramine hydrochloride (JAN/USP) <US>
    SLC6A4 (HTT)
     D00812  Desipramine hydrochloride (JAN/USP) <US>
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00812
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01730  Non-selective monoamine reuptake inhibitor
   DG00927  Desipramine
  DG01728  Tricyclic antidepressant
   DG00927  Desipramine
Other DBs
CAS: 58-28-6
PubChem: 7847877
ChEBI: 4449
LigandBox: D00812
NIKKAJI: J231.274C
KCF data

ATOM        21
            1   C1x C    12.5108  -18.1831
            2   C8y C    11.6661  -17.0701
            3   C8y C    12.0023  -15.7092
            4   N1y N    13.2672  -15.1293
            5   C1x C    13.9209  -18.2084
            6   C8y C    14.5246  -15.7535
            7   C8y C    14.8120  -17.1264
            8   C8x C    10.9921  -14.7378
            9   C8x C     9.6460  -15.1271
            10  C8x C     9.3098  -16.4880
            11  C8x C    10.3200  -17.4591
            12  C8x C    16.1472  -17.5648
            13  C8x C    17.1946  -16.6276
            14  C8x C    16.9074  -15.2547
            15  C8x C    15.5719  -14.8162
            16  C1b C    13.2889  -13.7502
            17  C1b C    14.5167  -13.0670
            18  C1b C    15.6886  -13.7686
            19  N1b N    16.9145  -13.0865
            20  C1a C    18.1530  -13.8273
            21  X   Cl   20.1707  -16.3481
BOND        22
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1