Entry

D00816                      Drug

Name

Nortriptyline hydrochloride (JP18/USP/INN);
Pamelor (TN)

Product

PAMELOR (SpecGx LLC)

Generic

NORTRIPTYLINE HCI (Direct_Rx), NORTRIPTYLINE HCI (Direct_Rx), NORTRIPTYLINE HCI (Direct_Rx), NORTRIPTYLINE HCL (Direct_Rx), NORTRIPTYLINE HYDROCHLORIDE (A-S Medication Solutions), NORTRIPTYLINE HYDROCHLORIDE (A-S Medication Solutions), NORTRIPTYLINE HYDROCHLORIDE (A-S Medication Solutions), NORTRIPTYLINE HYDROCHLORIDE (American Health Packaging), NORTRIPTYLINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), NORTRIPTYLINE HYDROCHLORIDE (AvPAK), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Bryant Ranch Prepack), NORTRIPTYLINE HYDROCHLORIDE (Cadila Healthcare Limited), NORTRIPTYLINE HYDROCHLORIDE (Clinical Solutions Wholesale), NORTRIPTYLINE HYDROCHLORIDE (DIRECT RX), NORTRIPTYLINE HYDROCHLORIDE (DIRECT RX), NORTRIPTYLINE HYDROCHLORIDE (DIRECT RX), NORTRIPTYLINE HYDROCHLORIDE (Denton Pharma), NORTRIPTYLINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), NORTRIPTYLINE HYDROCHLORIDE (Mayne Pharma), NORTRIPTYLINE HYDROCHLORIDE (Mayne Pharma), NORTRIPTYLINE HYDROCHLORIDE (NuCare Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (NuCare Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (NuCare Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (NuCare Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (Pharmaceutical Associates), NORTRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (Preferred Pharmaceuticals), NORTRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), NORTRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), NORTRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), NORTRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), NORTRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), NORTRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), NORTRIPTYLINE HYDROCHLORIDE (Proficient Rx LP), NORTRIPTYLINE HYDROCHLORIDE (Quality Care Products LLC), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (REMEDYREPACK), NORTRIPTYLINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), NORTRIPTYLINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), NORTRIPTYLINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), NORTRIPTYLINE HYDROCHLORIDE (Taro Pharmaceuticals U.S.A.), NORTRIPTYLINE HYDROCHLORIDE (Teva Pharmaceuticals USA), NORTRIPTYLINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA))

Formula

C19H21N. HCl

Exact mass

299.1441

Mol weight

299.8377

Structure

Simcomp

Class

Neuropsychiatric agent
DG01730  Non-selective monoamine reuptake inhibitor
DG01728  Tricyclic antidepressant
Metabolizing enzyme substrate
DG01644  CYP2D6 substrate

Remark

Therapeutic category:

1179

ATC code:

N06AA10

Chemical structure group:

DG00935

Product (DG00935):

D00816<JP/US>

Efficacy

Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI)

Disease

Depression [DS:H01646]

Target

SLC6A4 (HTT) [HSA:6532] [KO:K05037]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]

Pathway

hsa04721

Synaptic vesicle cycle

hsa04726

Serotonergic synapse

Metabolism

Enzyme: CYP2D6 [HSA:1565]

Interaction

Structure map

map07027

Antidepressants

map07048

Antimigraines

map07234

Neurotransmitter transporter inhibitors

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AA Non-selective monoamine reuptake inhibitors
     N06AA10 Nortriptyline
      D00816  Nortriptyline hydrochloride (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antidepressants
  Tricyclics
   Nortriptyline
    D00816  Nortriptyline hydrochloride (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00816  Nortriptyline hydrochloride (JP18/USP/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01730  Non-selective monoamine reuptake inhibitor
   DG00935  Nortriptyline
    D00816  Nortriptyline hydrochloride
  DG01728  Tricyclic antidepressant
   DG00935  Nortriptyline
    D00816  Nortriptyline hydrochloride
Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00935  Nortriptyline
    D00816  Nortriptyline hydrochloride
Drug classes [BR:br08332]
Neuropsychiatric agent
  DG01730  Non-selective monoamine reuptake inhibitor
   D00816  Nortriptyline hydrochloride
Target-based classification of drugs [BR:br08310]
Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D00816  Nortriptyline hydrochloride (JP18/USP/INN) <JP/US>
    SLC6A4 (HTT)
     D00816  Nortriptyline hydrochloride (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00816  Nortriptyline hydrochloride
  D00816  Nortriptyline hydrochloride tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00816
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
  D00816
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01730  Non-selective monoamine reuptake inhibitor
   DG00935  Nortriptyline
  DG01728  Tricyclic antidepressant
   DG00935  Nortriptyline
Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00935  Nortriptyline

Other DBs

CAS:

894-71-3

PubChem:

7847881

ChEBI:

7641

LigandBox:

D00816

NIKKAJI:

J358.588C

KCF data

ATOM        21
            1   C1x C    11.2452  -10.4773
            2   C8y C    10.4008   -9.3647
            3   C8y C    10.7369   -8.0042
            4   C2y C    12.0014   -7.4245
            5   C1x C    12.6548  -10.5026
            6   C8y C    13.2583   -8.0485
            7   C8y C    13.5456   -9.4210
            8   C8x C     9.7270   -7.0331
            9   C8x C     8.3814   -7.4223
            10  C8x C     8.0453   -8.7828
            11  C8x C     9.0551   -9.7536
            12  C8x C    14.8804   -9.8593
            13  C8x C    15.9275   -8.9223
            14  C8x C    15.6404   -7.5498
            15  C8x C    14.3053   -7.1115
            16  C2b C    11.9531   -6.0458
            17  C1b C    13.1804   -5.3628
            18  C1b C    14.3520   -6.0642
            19  N1b N    15.5775   -5.3823
            20  C1a C    16.8156   -6.1229
            21  X   Cl   18.9026   -8.6429
BOND        22
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 2
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1