Venlafaxine hydrochloride


Entry
D00821                      Drug                                   
Name
Venlafaxine hydrochloride (JAN/USP);
Effexor (TN)
Product
EFFEXOR (Wyeth Pharmaceuticals LLC)
  Generic
VENLAFAXINE (A-S Medication Solutions), VENLAFAXINE (A-S Medication Solutions), VENLAFAXINE (A-S Medication Solutions), VENLAFAXINE (A-S Medication Solutions), VENLAFAXINE (A-S Medication Solutions), VENLAFAXINE (Alembic Pharmaceuticals), VENLAFAXINE (Alembic Pharmaceuticals Limited), VENLAFAXINE (American Health Packaging), VENLAFAXINE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), VENLAFAXINE (Aphena Pharma Solutions - Tennessee), VENLAFAXINE (Ascend Laboratories), VENLAFAXINE HYDROCHLORIDE (Ascent Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (AvPAK), VENLAFAXINE (BluePoint Laboratories), VENLAFAXINE HYDROCHLORIDE (BluePoint Laboratories), VENLAFAXINE (Bryant Ranch Prepack), VENLAFAXINE (Bryant Ranch Prepack), VENLAFAXINE (Bryant Ranch Prepack), VENLAFAXINE (Cadila Pharmaceuticals Limited), VENLAFAXINE (Cadila Pharmaceuticals Limited), VENLAFAXINE HYDROCHLORIDE (Camber Pharmaceuticals), EFFEXOR (DIRECT RX), VENLAFAXINE (Denton Pharma), VENLAFAXINE (Direct Rx), VENLAFAXINE (Direct_Rx), VENLAFAXINE (Direct_Rx), VENLAFAXINE (Dr. Reddy's Laboratories), VENLAFAXINE (Golden State Medical Supply), VENLAFAXINE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), VENLAFAXINE (Lannett Company), VENLAFAXINE (Northstar Rx LLC), VENLAFAXINE (NuCare Pharmaceuticals), VENLAFAXINE (PD-Rx Pharmaceuticals), VENLAFAXINE (Proficient Rx LP), VENLAFAXINE (Proficient Rx LP), VENLAFAXINE (Proficient Rx LP), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE (St. Mary's Medical Park Pharmacy), VENLAFAXINE (Sun Pharmaceutical Industries), VENLAFAXINE HYDROCHLORIDE (XLCare Pharmaceuticals), VENLAFAXINE (Zydus Pharmaceuticals (USA)), VENLAFAXINE HCL (Advanced Rx Pharmacy of Tennessee), VENLAFAXINE HCL ER (Direct_Rx), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (A-S Medication Solutions), VENLAFAXINE HYDROCHLORIDE (ACETRIS HEALTH), VENLAFAXINE HYDROCHLORIDE (American Health Packaging), VENLAFAXINE HYDROCHLORIDE (Annora Pharma Private Limited), VENLAFAXINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VENLAFAXINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VENLAFAXINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), VENLAFAXINE HYDROCHLORIDE (Aurobindo Pharma Limited), VENLAFAXINE (Aurobindo Pharma Limited), VENLAFAXINE HYDROCHLORIDE (AvKARE), VENLAFAXINE HYDROCHLORIDE (AvKARE), VENLAFAXINE HYDROCHLORIDE (AvPAK), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE (Bryant Ranch Prepack), VENLAFAXINE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Bryant Ranch Prepack), VENLAFAXINE HYDROCHLORIDE (Cadila Healthcare Limited), VENLAFAXINE HYDROCHLORIDE (Cadila Healthcare Limited), VENLAFAXINE HYDROCHLORIDE (Camber Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Cardinal Health), VENLAFAXINE HYDROCHLORIDE (Clinical Solutions Wholesale), VENLAFAXINE (Contract Pharmacy Services-PA), VENLAFAXINE (Contract Pharmacy Services-PA), VENLAFAXINE HYDROCHLORIDE (DIRECT RX), VENLAFAXINE HYDROCHLORIDE (DIRECT RX), VENLAFAXINE HYDROCHLORIDE (Denton Pharma), VENLAFAXINE HYDROCHLORIDE (Dr. Reddy's Laboratories Limited), VENLAFAXINE HYDROCHLORIDE (Dr.Reddy's Laboratories), VENLAFAXINE HYDROCHLORIDE (Florida Pharmaceutical Products), VENLAFAXINE HYDROCHLORIDE (Golden State Medical Supply), VENLAFAXINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), VENLAFAXINE HYDROCHLORIDE (Lannett Company), VENLAFAXINE HYDROCHLORIDE (Macleods Pharmaceuticals Limited), VENLAFAXINE HYDROCHLORIDE (Major Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Major Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Medsource Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NCS HealthCare of KY), VENLAFAXINE HYDROCHLORIDE (NCS HealthCare of KY), VENLAFAXINE HYDROCHLORIDE (Nivagen Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NorthStar RxLLC), VENLAFAXINE HYDROCHLORIDE (Northstar Rx LLC.), VENLAFAXINE HYDROCHLORIDE (Nostrum Laboratories), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals), VENLAFAXINE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Preferred Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Proficient Rx LP), VENLAFAXINE HYDROCHLORIDE (Proficient Rx LP), VENLAFAXINE HYDROCHLORIDE (Proficient Rx LP), VENLAFAXINE HYDROCHLORIDE (Proficient Rx LP), VENLAFAXINE HYDROCHLORIDE (Proficient Rx LP), VENLAFAXINE HYDROCHLORIDE (QPharma), VENLAFAXINE HYDROCHLORIDE (Quality Care Products), VENLAFAXINE HYDROCHLORIDE (Quality Care Products), VENLAFAXINE HYDROCHLORIDE (Quality Care Products), VENLAFAXINE (Quality Care Products), VENLAFAXINE HYDROCHLORIDE (Quality Care Products), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (REMEDYREPACK), VENLAFAXINE HYDROCHLORIDE (RPK Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (RPK Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (RPK Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (RPK Pharmaceuticals), VENLAFAXINE (Rising Health), VENLAFAXINE (St. Mary's Medical Park Pharmacy), VENLAFAXINE (St. Mary's Medical Park Pharmacy), VENLAFAXINE HYDROCHLORIDE (Sun Pharmaceutical Industries), VENLAFAXINE HYDROCHLORIDE (Teva Pharmaceuticals USA), VENLAFAXINE HYDROCHLORIDE (Teva Pharmaceuticals USA), VENLAFAXINE HYDROCHLORIDE (Torrent Pharmaceuticals Limited), VENLAFAXINE HYDROCHLORIDE (Trigen Laboratories), VENLAFAXINE HYDROCHLORIDE (Vertical Pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (Yaopharma), VENLAFAXINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), VENLAFAXINE HYDROCHLORIDE (medsource pharmaceuticals), VENLAFAXINE HYDROCHLORIDE (NuCare Pharmaceuticals)
Formula
C17H27NO2. HCl
Exact mass
313.1809
Mol weight
313.8627
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01658  Serotonin and norepinephrine reuptake inhibitor (SNRI)
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1179
ATC code: N06AX16
Chemical structure group: DG00959
Product (DG00959): D00821<JP/US> D12403<US>
Efficacy
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI)
  Disease
Major depressive disorder [DS:H01646]
Generalized anxiety disorder [DS:H01662]
Social anxiety disorder [DS:H01670]
Panic disorder [DS:H01664]
Comment
serotonin norepinephrine reuptake inhibitor (SNRI)
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565]; CYP3A4 [HSA:1576]
Interaction
Structure map
map07027  Antidepressants
map07234  Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX16 Venlafaxine
      D00821  Venlafaxine hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Antidepressants
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Venlafaxine
    D00821  Venlafaxine hydrochloride (JAN/USP)
 Anxiolytics
  SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
   Venlafaxine
    D00821  Venlafaxine hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00821  Venlafaxine hydrochloride (JAN/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01658  Serotonin and norepinephrine reuptake inhibitor (SNRI)
   DG00959  Venlafaxine
    D00821  Venlafaxine hydrochloride
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00959  Venlafaxine
    D00821  Venlafaxine hydrochloride
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00959  Venlafaxine
     D00821  Venlafaxine hydrochloride
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D00821  Venlafaxine hydrochloride (JAN/USP) <JP/US>
    SLC6A4 (HTT)
     D00821  Venlafaxine hydrochloride (JAN/USP) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00821
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00821
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00821
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01658  Serotonin and norepinephrine reuptake inhibitor (SNRI)
   DG00959  Venlafaxine
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00959  Venlafaxine
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00959  Venlafaxine
Other DBs
CAS: 99300-78-4
PubChem: 7847886
ChEBI: 9944
LigandBox: D00821
NIKKAJI: J397.344A
KCF data

ATOM        21
            1   X   Cl   27.9676  -14.4620
            2   C8x C    18.0600  -14.7700
            3   C8y C    18.0600  -16.1700
            4   C8x C    19.2724  -16.8700
            5   C8x C    20.4849  -16.1700
            6   C8y C    20.4849  -14.7700
            7   C8x C    19.2724  -14.0700
            8   C1x C    22.9097  -16.1700
            9   C1z C    22.9097  -14.7700
            10  C1c C    21.6973  -14.0700
            11  C1x C    24.1222  -16.8700
            12  C1x C    25.3346  -16.1700
            13  C1x C    25.3346  -14.7700
            14  C1x C    24.1222  -14.0700
            15  O2a O    16.8476  -16.8700
            16  C1a C    15.6521  -16.1796
            17  C1b C    21.6973  -12.6700
            18  O1a O    22.9097  -13.3700
            19  N1c N    20.4869  -11.9712
            20  C1a C    19.2924  -12.6610
            21  C1a C    20.4868  -10.5702
BOND        21
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     8   9 1
            8     9  10 1
            9     6  10 1
            10    8  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14    9  14 1
            15    3  15 1
            16   15  16 1
            17   10  17 1
            18    9  18 1
            19   17  19 1
            20   19  20 1
            21   19  21 1