| Entry |
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| Name | Buprenorphine hydrochloride (JP18/USP); Buprenex (TN) | ||||||||||
| Product | BELBUCA (BioDelivery Sciences International), BUPRENEX (Indivior), BELBUCA (Quality Care Products) | ||||||||||
| Generic | BUPRENORPHINE (A-S Medication Solutions), BUPRENORPHINE (Actavis Pharma), BUPRENORPHINE (American Health Packaging), BUPRENORPHINE (Bryant Ranch Prepack), BUPRENORPHINE (Bryant Ranch Prepack), BUPRENORPHINE (Bryant Ranch Prepack), BUPRENORPHINE (Clinical Solutions Wholesale), BUPRENORPHINE (NuCare Pharmaceuticals), BUPRENORPHINE (Rhodes Pharmaceuticals L.P.), BUPRENORPHINE (Sun Pharmaceutical Industries), BUPRENORPHINE HCL (Bryant Ranch Prepack), BUPRENORPHINE HCL (Clinical Solutions Wholesale), BUPRENORPHINE HCL (Hikma Pharmaceuticals USA), BUPRENORPHINE HCL (Lake Erie Medical DBA Quality Care Products LLC), BUPRENORPHINE HCL (Major Pharmaceuticals), BUPRENORPHINE HCL (REMEDYREPACK), BUPRENORPHINE HCL (REMEDYREPACK), BUPRENORPHINE HYDROCHLORIDE (A-S Medication Solutions), BUPRENORPHINE HYDROCHLORIDE (American Regent), BUPRENORPHINE HYDROCHLORIDE (Bryant Ranch Prepack), BUPRENORPHINE HYDROCHLORIDE (Hi-Tech Pharmacal), BUPRENORPHINE HYDROCHLORIDE (Hikma Pharmaceuticals USA), BUPRENORPHINE HYDROCHLORIDE (Hospira), BUPRENORPHINE HYDROCHLORIDE (Par Pharmaceutical) | ||||||||||
| Formula | C29H41NO4. HCl | ||||||||||
| Exact mass | 503.2802 | ||||||||||
| Mol weight | 504.1011 | ||||||||||
| Structure |  | ||||||||||
| Simcomp | |||||||||||
| Class | Analgesic DG01984 Opioid analgesics DG01586 Opioid receptor antagonist Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate | ||||||||||
| Remark |
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| Efficacy | Analgesic, Opioid receptor agonist/antagonist | ||||||||||
| Comment | Morphinan derivative, Oripavine derivative | ||||||||||
| Target | OPRK1 [HSA:4986] [KO:K04214] OPRM1 [HSA:4988] [KO:K04215] | ||||||||||
| Pathway |
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| Metabolism | Enzyme: CYP3A4 [HSA:1576] | ||||||||||
| Interaction | |||||||||||
| Structure map |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] N NERVOUS SYSTEM N02 ANALGESICS N02A OPIOIDS N02AE Oripavine derivatives N02AE01 Buprenorphine D00836 Buprenorphine hydrochloride (JP18/USP) <JP/US> N07 OTHER NERVOUS SYSTEM DRUGS N07B DRUGS USED IN ADDICTIVE DISORDERS N07BC Drugs used in opioid dependence N07BC01 Buprenorphine D00836 Buprenorphine hydrochloride (JP18/USP) <JP/US> USP drug classification [BR:br08302] Analgesics Opioid Analgesics, Long-acting Buprenorphine D00836 Buprenorphine hydrochloride (JP18/USP) Anti-Addiction/Substance Abuse Treatment Agents Opioid Dependence Buprenorphine D00836 Buprenorphine hydrochloride (JP18/USP) Therapeutic category of drugs in Japan [BR:br08301] 1 Agents affecting nervous system and sensory organs 11 Agents affecting central nervous system 114 Antipyretics and analgesics, anti-inflammatory agents 1149 Others D00836 Buprenorphine hydrochloride (JP18/USP) Drug groups [BR:br08330] Analgesic DG01984 Opioid analgesics DG00820 Buprenorphine D00836 Buprenorphine hydrochloride DG01586 Opioid receptor antagonist DG00820 Buprenorphine D00836 Buprenorphine hydrochloride Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate DG00820 Buprenorphine D00836 Buprenorphine hydrochloride Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Rhodopsin family Opioid OPRM1 D00836 Buprenorphine hydrochloride (JP18/USP) <JP/US> OPRK1 D00836 Buprenorphine hydrochloride (JP18/USP) <JP/US> Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D00836 Buprenorphine hydrochloride Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D00836 Drug groups [BR:br08330] Analgesic DG01984 Opioid analgesics DG00820 Buprenorphine DG01586 Opioid receptor antagonist DG00820 Buprenorphine Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate DG00820 Buprenorphine | ||||||||||
| Other DBs |
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| KCF data | ATOM 35 1 X Cl 23.5865 -20.2981 2 C1z C 16.6051 -15.0621 3 C1z C 17.7919 -15.7602 4 C1y C 15.4182 -15.7602 5 C8y C 16.6051 -13.7356 6 C1x C 17.7919 -14.3639 7 C1y C 18.9787 -15.0621 8 C1x C 17.7919 -17.1565 9 C1x C 17.2334 -16.8074 10 C1z C 15.4182 -17.0867 11 O2x O 14.7899 -14.2243 12 C8y C 15.4880 -13.0375 13 C8y C 17.8617 -13.0375 14 C1x C 20.1656 -14.3639 15 N1y N 20.1656 -15.7602 16 C1x C 18.9785 -13.7356 17 C1y C 16.6051 -17.7848 18 C1x C 16.0466 -16.1093 19 C8y C 15.4880 -11.6412 20 C8x C 17.8617 -11.6412 21 C1b C 21.3524 -15.1319 22 C8x C 16.6749 -10.9431 23 O1a O 14.3012 -10.9431 24 C1y C 22.5392 -15.8300 25 C1x C 23.2374 -17.0169 26 C1x C 23.9355 -15.8300 27 O2a O 14.0220 -17.0867 28 C1a C 13.3238 -15.8998 29 C1d C 17.3032 -18.9717 30 C1a C 18.6995 -18.9717 31 C1d C 16.6051 -20.1585 32 O1a O 18.0013 -20.1585 33 C1a C 15.2088 -20.1585 34 C1a C 17.3032 -21.3453 35 C1a C 15.7673 -21.4151 BOND 40 1 2 6 1 #Up 2 3 7 1 3 3 8 1 4 3 9 1 #Down 5 4 10 1 6 4 11 1 #Down 7 5 12 1 8 5 13 2 9 6 14 1 10 7 15 1 #Up 11 7 16 1 12 8 17 1 13 9 18 1 14 12 19 2 15 13 20 1 16 15 21 1 17 19 22 1 18 19 23 1 19 10 17 1 20 10 18 1 #Down 21 11 12 1 22 13 16 1 23 15 14 1 #Up 24 20 22 2 25 2 3 1 26 21 24 1 27 2 4 1 28 2 5 1 29 24 25 1 30 24 26 1 31 26 25 1 32 10 27 1 33 27 28 1 34 17 29 1 35 29 30 1 #Up 36 29 31 1 37 29 32 1 #Down 38 31 33 1 39 31 34 1 40 31 35 1 |