Entry

D00839                      Drug

Name

Hydromorphone hydrochloride (JAN/USP);
Dilaudid (TN);
Exalgo (TN);
Palladone (TN)

Product

DILAUDID (Fresenius Kabi USA), DILAUDID (Fresenius Kabi USA), HYDROMORPHONE HYDROCHLORIDE (Fresenius Kabi USA), HYDROMORPHONE HYDROCHLORIDE (Hospira), HYDROMORPHONE HYDROCHLORIDE (Hospira), DILAUDID (Rhodes Pharmaceuticals L.P.)

Generic

HYDROMORPHONE HYDROCHLORIDE (Akorn), HYDROMORPHONE HYDROCHLORIDE (American Health Packaging), HYDROMORPHONE HYDROCHLORIDE (American Health Packaging), HYDROMORPHONE HYDROCHLORIDE (Ascent Pharmaceuticals), HYDROMORPHONE HYDROCHLORIDE (Aurolife Pharma), HYDROMORPHONE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROMORPHONE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROMORPHONE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROMORPHONE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROMORPHONE HYDROCHLORIDE (Bryant Ranch Prepack), HYDROMORPHONE HYDROCHLORIDE (Camber Pharmaceuticals), HYDROMORPHONE HYDROCHLORIDE (Hikma Pharmaceuticals USA), HYDROMORPHONE HYDROCHLORIDE (Hikma Pharmaceuticals USA), HYDROMORPHONE HYDROCHLORIDE (Hospira), HYDROMORPHONE HYDROCHLORIDE (Lannett Company), HYDROMORPHONE HYDROCHLORIDE (Lohxa), HYDROMORPHONE HYDROCHLORIDE (Padagis US LLC), HYDROMORPHONE HYDROCHLORIDE (RedPharm Drug), HYDROMORPHONE HYDROCHLORIDE (RedPharm Drug), HYDROMORPHONE HYDROCHLORIDE (Rhodes Pharmaceuticals L.P.), HYDROMORPHONE HYDROCHLORIDE (SpecGx LLC), HYDROMORPHONE HYDROCHLORIDE (Teva Parenteral Medicines), HYDROMORPHONE HYDROCHLORIDE (Trigen Laboratories), HYDROMORPHONE HYDROCHLORIDE (XLCare Pharmaceuticals)

Formula

C17H19NO3. HCl

Exact mass

321.1132

Mol weight

321.7986

Structure

Simcomp

Class

Neuropsychiatric agent
DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
DG01984  Opioid analgesics
Metabolizing enzyme substrate
DG02924  UGT substrate

Remark

Therapeutic category:

8119

ATC code:

N02AA03

Chemical structure group:

DG00811

Product (DG00811):

D00839<JP/US>

Efficacy

Analgesic (narcotic), Opioid receptor agonist

Comment

Opium alkaloid

Target

OPRM1 [HSA:4988] [KO:K04215]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

Metabolism

Enzyme: UGT [KO:K00699]

Interaction

Structure map

map07039

Opioid analgesics

map07224

Opioid receptor agonists/antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AA Natural opium alkaloids
     N02AA03 Hydromorphone
      D00839  Hydromorphone hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Analgesics
  Opioid Analgesics, Long-acting
   Hydromorphone
    D00839  Hydromorphone hydrochloride (JAN/USP)
  Opioid Analgesics, Short-acting
   Hydromorphone
    D00839  Hydromorphone hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
8  Narcotics
  81  Alkaloidal narcotics
   811  Opium alkaloids
    8119  Others
     D00839  Hydromorphone hydrochloride (JAN/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00811  Hydromorphone
     D00839  Hydromorphone hydrochloride
Analgesic
  DG01984  Opioid analgesics
   DG00811  Hydromorphone
    D00839  Hydromorphone hydrochloride
Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG00811  Hydromorphone
    D00839  Hydromorphone hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D00839  Hydromorphone hydrochloride (JAN/USP) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D00839
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00839
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00811  Hydromorphone
Analgesic
  DG01984  Opioid analgesics
   DG00811  Hydromorphone
Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG00811  Hydromorphone

Other DBs

CAS:

71-68-1

PubChem:

7847904

ChEBI:

5791

LigandBox:

D00839

NIKKAJI:

J252.891F

KCF data

ATOM        22
            1   X   Cl   33.7684  -12.5160
            2   C1z C    26.4194  -13.3594
            3   C8y C    26.4194  -12.0354
            4   C1y C    27.6040  -14.0561
            5   C1y C    25.3045  -13.9865
            6   C1x C    27.6040  -12.7323
            7   C8y C    25.3045  -11.4083
            8   C8y C    27.6040  -11.4083
            9   C1y C    28.7189  -13.3594
            10  C1x C    27.6040  -15.3104
            11  O2x O    23.9806  -12.6625
            12  C5x C    25.3045  -15.3104
            13  C1x C    29.8337  -12.7323
            14  C8y C    25.3045  -10.0844
            15  C1x C    28.7189  -12.1051
            16  C8x C    27.6040  -10.0844
            17  N1y N    29.8337  -14.0561
            18  C1x C    26.4194  -16.0072
            19  O5x O    24.1897  -16.0072
            20  C8x C    26.4891   -9.4573
            21  O1a O    24.1897   -9.4573
            22  C1a C    31.2326  -14.0561
BOND        25
            1     2   3 1
            2     2   4 1
            3     2   5 1
            4     2   6 1 #Up
            5     3   7 2
            6     3   8 1
            7     4   9 1
            8     4  10 1
            9     5  11 1 #Down
            10    5  12 1
            11    6  13 1
            12    7  14 1
            13    8  15 1
            14    8  16 2
            15    9  17 1 #Up
            16   10  18 1
            17   12  19 2
            18   14  20 2
            19   14  21 1
            20    7  11 1
            21    9  15 1
            22   12  18 1
            23   13  17 1
            24   16  20 1
            25   17  22 1