Morphine sulfate

Entry

D00842                      Drug

Name

Morphine sulfate (USP);
Morphine sulfate hydrate (JP18);
Morphine sulfate pentahydrate;
Astramor PH (TN);
Avinza (TN);
Depodur (TN);
Kadian (TN);
MS contin (TN)

Product

MORPHINE SULFATE (ATLANTIC BIOLOGICALS CORP.), MORPHINE SULFATE (ATLANTIC BIOLOGICALS CORP.), MORPHINE SULFATE (ATLANTIC BIOLOGICALS CORP.), KADIAN (Allergan), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (DIRECTRX), MORPHINE SULFATE (Fresenius Kabi USA), MORPHINE SULFATE (Fresenius Kabi USA), MORPHINE SULFATE (Fresenius Kabi), MORPHINE SULFATE (Hikma Pharmaceuticals USA), MORPHINE SULFATE (Hikma Pharmaceuticals USA), MORPHINE SULFATE (Hikma Pharmaceuticals USA), MORPHINE SULFATE (Hikma Pharmaceuticals USA), DURAMORPH (Hikma Pharmaceuticals USA), MORPHINE SULFATE (Hospira), MORPHINE SULFATE (Hospira), MORPHINE SULFATE (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), MORPHINE SULFATE (Lake Erie Medical DBA Quality Care Products LLC), MORPHINE SULFATE (Lohxa), MORPHINE SULFATE (Pharmaceutical Associates), MORPHINE SULFATE (Precision Dose), MORPHINE SULFATE (Precision Dose), MORPHINE SULFATE (RedPharm Drug), MS CONTIN (Rhodes Pharmaceuticals L.P.)

Generic

MORPHINE SULFATE (ATLANTIC BIOLOGICALS CORP.), MORPHINE SULFATE (Actavis Pharma), MORPHINE SULFATE (Actavis Pharma), MORPHINE SULFATE (Actavis Pharma), MORPHINE SULFATE (Akorn), MORPHINE SULFATE (American Health Packaging), MORPHINE SULFATE (American Health Packaging), MORPHINE SULFATE (Amneal Pharmaceuticals of New York LLC), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Bryant Ranch Prepack), MORPHINE SULFATE (Civica), MORPHINE SULFATE (Hikma Pharmaceuticals USA), MORPHINE SULFATE (Hospira), MORPHINE SULFATE (International Medication Systems), MORPHINE SULFATE (Lupin Pharmaceuticals), MORPHINE SULFATE (Major Pharmaceuticals), MORPHINE SULFATE (Mayne Pharma), MORPHINE SULFATE (Mayne Pharma), MORPHINE SULFATE (Novel Laboratories), MORPHINE SULFATE (Pharmaceutical Associates), MITIGO (Piramal Critical Care), MORPHINE SULFATE (Quality Care Products LLC), MORPHINE SULFATE (Quality Care Products), MORPHINE SULFATE (Quality Care Products), MORPHINE SULFATE (Quality Care Products), MORPHINE SULFATE (RedPharm Drug), MORPHINE SULFATE (RedPharm Drug), MORPHINE SULFATE (Rhodes Pharmaceuticals L. P.), MORPHINE SULFATE (Rhodes Pharmaceuticals L.P.), MORPHINE SULFATE (Safecor Health), MORPHINE SULFATE (SpecGx LLC), MORPHINE SULFATE (SpecGx LLC), MORPHINE SULFATE (Sun Pharmaceutical Industries), MORPHINE SULFATE (Tris Pharma), MORPHINE SULFATE (Upsher-Smith Laboratories), MORPHINE SULFATE (Upsher-Smith Laboratories), MORPHINE SULFATE (Winder Laboratories LLC)

Formula

(C17H19NO3)2. H2SO4. 5H2O

Exact mass

758.2932

Mol weight

758.8302

Structure

Simcomp

Class

Neuropsychiatric agent
DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
DG01984  Opioid analgesics
Metabolizing enzyme substrate
DG02924  UGT substrate

Remark

Therapeutic category:

8114

ATC code:

N02AA01

Chemical structure group:

DG00810

Product (DG00810):

D00842<JP/US> D02271<JP>

Efficacy

Analgesic (narcotic), Opioid receptor agonist

Comment

Opium alkaloid

Target

OPRM1 [HSA:4988] [KO:K04215]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

Metabolism

Enzyme: UGT [KO:K00699]

Interaction

Structure map

map07039

Opioid analgesics

map07224

Opioid receptor agonists/antagonists

Other map

map05032

Morphine addiction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AA Natural opium alkaloids
     N02AA01 Morphine
      D00842  Morphine sulfate (USP) <JP/US>
USP drug classification [BR:br08302]
Analgesics
  Opioid Analgesics, Long-acting
   Morphine
    D00842  Morphine sulfate (USP)
  Opioid Analgesics, Short-acting
   Morphine
    D00842  Morphine sulfate (USP)
Therapeutic category of drugs in Japan [BR:br08301]
8  Narcotics
  81  Alkaloidal narcotics
   811  Opium alkaloids
    8114  Morphines
     D00842  Morphine sulfate (USP); Morphine sulfate hydrate (JP18)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00810  Morphine
     D00842  Morphine sulfate
Analgesic
  DG01984  Opioid analgesics
   DG00810  Morphine
    D00842  Morphine sulfate
Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG00810  Morphine
    D00842  Morphine sulfate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D00842  Morphine sulfate (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00842  Morphine sulfate hydrate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00842
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01563  mu-Opioid receptor agonist
    DG00810  Morphine
Analgesic
  DG01984  Opioid analgesics
   DG00810  Morphine
Metabolizing enzyme substrate
  DG02924  UGT substrate
   DG00810  Morphine

Other DBs

CAS:

6211-15-0

PubChem:

7847907

ChEBI:

50731

LigandBox:

D00842

NIKKAJI:

J244.872F

KCF data

ATOM        52
            1   S4a S    29.2515  -20.6431
            2   O1d O    29.2457  -19.2411
            3   O1d O    29.2457  -22.0511
            4   O1d O    27.8437  -20.6374
            5   O1d O    30.6536  -20.6431
            6   O0  O    30.0311  -24.2752
            7   C1z C    18.8784  -23.6206
            8   C8y C    18.8784  -22.2988
            9   C1y C    20.0610  -24.3162
            10  C1y C    17.7653  -24.2467
            11  C1x C    20.0610  -22.9945
            12  C8y C    17.7653  -21.6727
            13  C8y C    20.0610  -21.6727
            14  C1y C    21.1741  -23.6206
            15  C2x C    20.0610  -25.5684
            16  O2x O    16.4436  -22.9248
            17  C1y C    17.7653  -25.5684
            18  C1x C    22.2871  -22.9945
            19  C8y C    17.7653  -20.3509
            20  C1x C    21.1741  -22.3683
            21  C8x C    20.0610  -20.3509
            22  N1y N    22.2871  -24.3162
            23  C2x C    18.8784  -26.2641
            24  O1a O    16.6523  -26.2641
            25  C8x C    18.9480  -19.7249
            26  O1a O    16.6523  -19.7249
            27  C1a C    23.6837  -24.3162
            28  O0  O    30.0311  -24.2752
            29  O0  O    30.0311  -24.2752
            30  O0  O    30.0311  -24.2752
            31  O0  O    30.0311  -24.2752
            32  C1z C    18.8784  -23.6206
            33  C8y C    18.8784  -22.2988
            34  C8y C    17.7653  -21.6727
            35  C8y C    17.7653  -20.3509
            36  C8x C    18.9480  -19.7249
            37  C8x C    20.0610  -20.3509
            38  C8y C    20.0610  -21.6727
            39  C1x C    21.1741  -22.3683
            40  C1y C    21.1741  -23.6206
            41  C1y C    20.0610  -24.3162
            42  C2x C    20.0610  -25.5684
            43  C2x C    18.8784  -26.2641
            44  C1y C    17.7653  -25.5684
            45  C1y C    17.7653  -24.2467
            46  O2x O    16.4436  -22.9248
            47  O1a O    16.6523  -26.2641
            48  N1y N    22.2871  -24.3162
            49  C1x C    22.2871  -22.9945
            50  C1x C    20.0610  -22.9945
            51  C1a C    23.6837  -24.3162
            52  O1a O    16.6523  -19.7249
BOND        54
            1     1   2 2
            2     1   3 2
            3     1   4 1
            4     1   5 1
            5     7   8 1
            6     7   9 1
            7     7  10 1
            8     7  11 1 #Up
            9     8  12 2
            10    8  13 1
            11    9  14 1
            12    9  15 1
            13   10  16 1 #Down
            14   10  17 1
            15   11  18 1
            16   12  19 1
            17   13  20 1
            18   13  21 2
            19   14  22 1 #Up
            20   15  23 2
            21   17  24 1 #Down
            22   19  25 2
            23   19  26 1
            24   12  16 1
            25   14  20 1
            26   17  23 1
            27   18  22 1
            28   21  25 1
            29   22  27 1
            30   32  33 1
            31   32  41 1
            32   32  45 1
            33   32  50 1 #Up
            34   33  34 2
            35   33  38 1
            36   41  40 1
            37   41  42 1
            38   45  46 1 #Down
            39   45  44 1
            40   50  49 1
            41   34  35 1
            42   38  39 1
            43   38  37 2
            44   40  48 1 #Up
            45   42  43 2
            46   44  47 1 #Down
            47   35  36 2
            48   35  52 1
            49   34  46 1
            50   40  39 1
            51   44  43 1
            52   49  48 1
            53   37  36 1
            54   48  51 1
BRACKET     1    28.0700  -25.2700   28.0700  -23.2400
            1    30.4500  -23.2400   30.4500  -25.2700
            1  5
ORIGINAL  1    6
REPEAT    1   29  30  31  32
            2    14.5600  -27.0200   14.5600  -18.6900
            2    25.4800  -18.6900   25.4800  -27.0200
            2  2
ORIGINAL  2    7   8  12  19  25  21  13  20  14   9  15  23  17  10  16  24
            2   27  22  18  11  28  26
REPEAT    2   33  34  35  36  37  38  39  40  41  42  43  44  45  46  47  48
            2   49  50  51  52  53  54