Entry

D00847                      Drug

Name

Oxycodone hydrochloride (USP);
Oxecta (TN);
Oxycontin (TN);
Roxicodone (TN)

Product

XTAMPZA (Collegium Pharmaceutical), OXYCODONE HYDROCHLORIDE (Camber Pharmaceuticals), OXYCODONE HYDROCHLORIDE (Genus Lifesciences), OXYCODONE HYDROCHLORIDE (Genus Lifesciences), ROXYBOND (Protega Pharmaceuticals LLC), OXYCONTIN (Purdue Pharma LP), OXYCODONE HYDROCHLORIDE (RedPharm Drug), OXYCODONE HYDROCHLORIDE (RedPharm Drug), ROXICODONE (SpecGx LLC), OXYCODONE HYDROCHLORIDE (VistaPharm), OXAYDO (Zyla Life Sciences US)

Generic

OXYCODONE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Major Pharmaceuticals), OXYCODONE HYDROCHLORIDE (NuCare Pharmaceuticals), OXYCODONE HCL (Amneal Pharmaceuticals NY LLC), OXYCODONE HCL (DIRECT RX), OXYCODONE HCL (KVK-Tech), OXYCODONE HCL (Quality Care Products), OXYCODONE HYDCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), OXYCODONE HYDCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), OXYCODONE HYDROCHLORIDE (ANI Pharmaceuticals), OXYCODONE HYDROCHLORIDE (ANI Pharmaceuticals), OXYCODONE HYDROCHLORIDE (ATLANTIC BIOLOGICALS CORP.), OXYCODONE HYDROCHLORIDE (ATLANTIC BIOLOGICALS CORP.), OXYCODONE HYDROCHLORIDE (ATLANTIC BIOLOGICALS CORP.), OXYCODONE HYDROCHLORIDE (Actavis Pharma), OXYCODONE HYDROCHLORIDE (Akorn), OXYCODONE HYDROCHLORIDE (Alvogen), OXYCODONE HYDROCHLORIDE (American Health Packaging), OXYCODONE HYDROCHLORIDE (American Health Packaging), OXYCODONE HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), OXYCODONE HYDROCHLORIDE (Aurolife Pharma), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Bryant Ranch Prepack), OXYCODONE HYDROCHLORIDE (Camber Pharmaceuticals), OXYCODONE HYDROCHLORIDE (DIRECT RX), OXYCODONE HYDROCHLORIDE (DIRECT RX), OXYCODONE HYDROCHLORIDE (Direct_Rx), OXYCODONE HYDROCHLORIDE (Direct_Rx), OXYCODONE HYDROCHLORIDE (Epic Pharma), OXYCODONE HYDROCHLORIDE (Eywa Pharma), OXYCODONE HYDROCHLORIDE (Eywa Pharma), OXYCODONE HYDROCHLORIDE (Glenmark Pharmaceuticals), OXYCODONE HYDROCHLORIDE (Glenmark Pharmaceuticals), OXYCODONE HYDROCHLORIDE (Golden State Medical Supply), OXYCODONE HYDROCHLORIDE (Hi-Tech Pharmacal), OXYCODONE HYDROCHLORIDE (Hikma Pharmceuticals USA), OXYCODONE HYDROCHLORIDE (KVK-TECH), OXYCODONE HYDROCHLORIDE (KVK-TECH), OXYCODONE HYDROCHLORIDE (KVK-Tech), OXYCODONE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), OXYCODONE HYDROCHLORIDE (Lannett Company), OXYCODONE HYDROCHLORIDE (Lupin Pharmaceuticals), OXYCODONE HYDROCHLORIDE (Lupin Pharmaceuticals), OXYCODONE HYDROCHLORIDE (MAJOR PHARMACEUTICALS), OXYCODONE HYDROCHLORIDE (MAJOR PHARMACEUTICALS), OXYCODONE HYDROCHLORIDE (Major Pharmaceuticals), OXYCODONE HYDROCHLORIDE (Major Pharmaceuticals), OXYCODONE HYDROCHLORIDE (Major Pharmaceuticals), OXYCODONE HYDROCHLORIDE (Mayne Pharma), OXYCODONE HYDROCHLORIDE (Mayne Pharma), OXYCODONE HYDROCHLORIDE (Morton Grove Pharmaceuticals), OXYCODONE HYDROCHLORIDE (NuCare Pharmaceuticals), OXYCODONE HYDROCHLORIDE (NuCare Pharmaceuticals), OXYCODONE HYDROCHLORIDE (Pharmaceutical Associates), OXYCODONE HYDROCHLORIDE (Pharmaceutical Associates), OXYCODONE HYDROCHLORIDE (Pharmaceutical Associates), OXYCODONE HYDROCHLORIDE (Precision Dose), OXYCODONE HYDROCHLORIDE (Precision Dose), OXYCODONE HYDROCHLORIDE (QUAGEN PHARMACEUTICALS LLC), OXYCODONE HYDROCHLORIDE (Quality Care Products), OXYCODONE HYDROCHLORIDE (RedPharm Drug), OXYCODONE HYDROCHLORIDE (RedPharm Drug), OXYCODONE HYDROCHLORIDE (RedPharm Drug), OXYCODONE HYDROCHLORIDE (RedPharm Drug), OXYCODONE HYDROCHLORIDE (RedPharm Drug), OXYCODONE HYDROCHLORIDE (Rhodes Pharmaceuticals L.P.), OXYCODONE HYDROCHLORIDE (Rhodes Pharmaceuticals L.P.), OXYCODONE HYDROCHLORIDE (Safecor Health), OXYCODONE HYDROCHLORIDE (SpecGx LLC), OXYCODONE HYDROCHLORIDE (SpecGx LLC), OXYCODONE HYDROCHLORIDE (Sun Pharmaceutical Industries), OXYCODONE HYDROCHLORIDE (Teva Pharmaceuticals USA), OXYCODONE HYDROCHLORIDE (VistaPharm), OXYCODONE HYDROCHLORIDE (XLCare Pharmaceuticals), OXYCODONE HYDROCHLORIDE ORAL SOLUTION (Aurolife Pharma)

Formula

C18H21NO4. HCl

Exact mass

351.1237

Mol weight

351.8246

Structure

Simcomp

Class

Neuropsychiatric agent
DG01564  Opioid receptor agonist
Analgesic
DG01984  Opioid analgesics
Metabolizing enzyme substrate
DG01644  CYP2D6 substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate

Remark

Same as:

C08026

ATC code:

N02AA05

Chemical structure group:

DG00813

Product (DG00813):

D00847<US> D05462<JP>

Product (mixture):

D02153<US>

Efficacy

Analgesic (narcotic), Opioid receptor agonist

Comment

Opium alkaloid

Target

OPRM1 [HSA:4988] [KO:K04215]
OPRK1 [HSA:4986] [KO:K04214]
OPRD1 [HSA:4985] [KO:K04213]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

Metabolism

Enzyme: CYP3A4 [HSA:1576]; CYP2D6 [HSA:1565]

Interaction

Structure map

map07039

Opioid analgesics

map07224

Opioid receptor agonists/antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AA Natural opium alkaloids
     N02AA05 Oxycodone
      D00847  Oxycodone hydrochloride (USP) <US>
USP drug classification [BR:br08302]
Analgesics
  Opioid Analgesics, Long-acting
   Oxycodone
    D00847  Oxycodone hydrochloride (USP)
  Opioid Analgesics, Short-acting
   Oxycodone
    D00847  Oxycodone hydrochloride (USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG00813  Oxycodone
    D00847  Oxycodone hydrochloride
Analgesic
  DG01984  Opioid analgesics
   DG00813  Oxycodone
    D00847  Oxycodone hydrochloride
Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00813  Oxycodone
    D00847  Oxycodone hydrochloride
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00813  Oxycodone
     D00847  Oxycodone hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D00847  Oxycodone hydrochloride (USP) <US>
    OPRK1
     D00847  Oxycodone hydrochloride (USP) <US>
    OPRD1
     D00847  Oxycodone hydrochloride (USP) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00847
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG00813  Oxycodone
Analgesic
  DG01984  Opioid analgesics
   DG00813  Oxycodone
Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00813  Oxycodone
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00813  Oxycodone

Other DBs

CAS:

124-90-3

PubChem:

7847912

ChEBI:

7859

LigandBox:

D00847

NIKKAJI:

J281.239H

KCF data

ATOM        24
            1   C1z C    24.4381  -17.6672
            2   C8y C    24.4321  -16.3168
            3   C1z C    25.6030  -18.3338
            4   C1y C    23.2847  -18.3454
            5   C8y C    23.2672  -15.6445
            6   C8y C    25.5972  -15.6445
            7   C1y C    26.7623  -17.6499
            8   C1x C    25.6087  -19.6668
            9   O1a O    26.7623  -19.2729
            10  O2x O    22.5833  -17.0126
            11  C5x C    23.2905  -19.6784
            12  C8y C    23.2672  -14.2999
            13  C1x C    26.7623  -16.3109
            14  C8x C    25.5972  -14.2999
            15  N1y N    27.9213  -18.3221
            16  C1x C    24.4554  -20.3450
            17  O5x O    22.1139  -20.3391
            18  C8x C    24.4321  -13.6277
            19  O2a O    22.0966  -13.6277
            20  C1a C    29.2659  -18.3221
            21  C1x C    27.9213  -16.9998
            22  C1x C    25.6435  -17.0412
            23  C1a C    20.8657  -14.3423
            24  X   Cl   29.6100  -14.9100
BOND        27
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1 #Down
            10    4  11 1
            11    5  12 2
            12    6  13 1
            13    6  14 1
            14    7  15 1 #Up
            15    8  16 1
            16   11  17 2
            17   12  18 1
            18   12  19 1
            19   15  20 1
            20    5  10 1
            21    7  13 1
            22   11  16 1
            23   14  18 2
            24   15  21 1
            25    1  22 1 #Up
            26   22  21 1
            27   19  23 1