Entry

D00850                      Drug

Name

Minocycline hydrochloride (JP18/USP);
Arestin (TN);
Dynacin (TN);
Minocin (TN);
Solodyn (TN)

Product

ZILXI (Journey Medical Corporation), AMZEEQ (Journey Medical Corporation), AMZEEQ (Journey Medical Corporation), MINOCIN (Aphena Pharma Solutions - Tennessee), SOLODYN (Bausch Health US LLC), MINOLIRA EXTENDED RELEASE (EPI Health), MINOCYCLINE HYDROCHLORIDE (JG Pharma), XIMINO (Journey Medical Corporation), MINOCIN (Melinta Therapeutics), ARESTIN (OraPharma)

Generic

MINOCYCLINE (AvKARE), MINOCYCLINE (Par Pharmaceutical), MINOCYCLINE HYDROCHLORIDE (A-S Medication Solutions), MINOCYCLINE HYDROCHLORIDE (A-S Medication Solutions), MINOCYCLINE HYDROCHLORIDE (A-S Medication Solutions), MINOCYCLINE HYDROCHLORIDE (A-S Medication Solutions), MINOCYCLINE HYDROCHLORIDE (A-S Medication Solutions), MINOCYCLINE HYDROCHLORIDE (A-S Medication Solutions), MINOCYCLINE HYDROCHLORIDE (Actavis Pharma), MINOCYCLINE HYDROCHLORIDE (Alvogen), MINOCYCLINE HYDROCHLORIDE (American Health Packaging), MINOCYCLINE HYDROCHLORIDE (Amneal Pharmaceuticals of New York), MINOCYCLINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), MINOCYCLINE HYDROCHLORIDE (Ascend Laboratories), MINOCYCLINE HYDROCHLORIDE (Aurobindo Pharma Limited), MINOCYCLINE HYDROCHLORIDE (Aurobindo Pharma Limited), MINOCYCLINE HYDROCHLORIDE (Aurobindo Pharma Limited), MINOCYCLINE HYDROCHLORIDE (AvKARE), MINOCYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), MINOCYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), MINOCYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), MINOCYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), MINOCYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), MINOCYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), MINOCYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), MINOCYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), MINOCYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), MINOCYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), MINOCYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), MINOCYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), MINOCYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), MINOCYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), MINOCYCLINE HYDROCHLORIDE (Bryant Ranch Prepack), MINOCYCLINE HYDROCHLORIDE (Cadila Healthcare Limited), MINOCYCLINE HYDROCHLORIDE (Cadila Healthcare Limited), MINOCYCLINE HYDROCHLORIDE (Clinical Solutions Wholesale), MINOCYCLINE HYDROCHLORIDE (DIRECT RX), MINOCYCLINE HYDROCHLORIDE (Denton Pharma), MINOCYCLINE HYDROCHLORIDE (Denton Pharma), MINOCYCLINE HYDROCHLORIDE (Direct Rx), MINOCYCLINE HYDROCHLORIDE (DirectRX), MINOCYCLINE HYDROCHLORIDE (DirectRX), MINOCYCLINE HYDROCHLORIDE (Direct_Rx), MINOCYCLINE HYDROCHLORIDE (Dr. Reddy's Laboratories Limited), MINOCYCLINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), MINOCYCLINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), MINOCYCLINE HYDROCHLORIDE (Lupin Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (Major Pharamceuticals), MINOCYCLINE HYDROCHLORIDE (NuCare Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (NuCare Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (NuCare Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (NuCare Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (NuCare Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (Oceanside Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (Preferred Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (Preferred Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (Proficient Rx LP), MINOCYCLINE HYDROCHLORIDE (Proficient Rx LP), MINOCYCLINE HYDROCHLORIDE (Proficient Rx LP), MINOCYCLINE HYDROCHLORIDE (Proficient Rx LP), MINOCYCLINE HYDROCHLORIDE (Proficient Rx LP), MINOCYCLINE HYDROCHLORIDE (PruGen Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (REMEDYREPACK), MINOCYCLINE HYDROCHLORIDE (REMEDYREPACK), MINOCYCLINE HYDROCHLORIDE (RPK Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (RPK Pharmaceuticals), MINOCYCLINE HYDROCHLORIDE (RedPharm Drug), MINOCYCLINE HYDROCHLORIDE (Sandoz), MINOCYCLINE HYDROCHLORIDE (Strides Pharma Science Limited), MINOCYCLINE (Sun Pharmaceutical Industries), MINOCYCLINE HYDROCHLORIDE (Sun Pharmaceutical Industries), MINOCYCLINE HYDROCHLORIDE (Torrent Pharmaceuticals Limited), MINOCYCLINE HYDROCHLORIDE (Torrent Pharmaceuticals Limited), MINOCYCLINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), MINOCYCLINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA))

Formula

C23H27N3O7. HCl

Exact mass

493.1616

Mol weight

493.9373

Structure

Simcomp

Class

Antibacterial
DG01197 Tetracycline antibiotic

Remark

Therapeutic category:

2760 6152

ATC code:

A01AB23 D10AF07 J01AA08

Chemical structure group:

DG00009

Product (DG00009):

D00850<JP/US>

Efficacy

Antibacterial, Protein biosynthesis inhibitor

Disease

Rocky Mountain spotted fever [DS:H00323]
Typhus fever [DS:H00322]
Q fever [DS:H00310]
Lymphogranuloma venereum [DS:H00348]
Psittacosis [DS:H00350]
Trachoma [DS:H00349]
Relapsing fever [DS:H00427]
Chancroid [DS:H00305]
Plague [DS:H00297]
Tularemia [DS:H00312]
Cholera [DS:H00110]
Campylobacter fetus infections [DS:H00321]
Brucellosis [DS:H00325]
Bartonellosis [DS:H00326]
Granuloma inguinale [DS:H01415]
Syphilis [DS:H00354]
Yaws [DS:H01318]
Listeriosis [DS:H00332]
Anthrax [DS:H00328]
Vincent's infection [DS:H01440]
Actinomycosis [DS:H01325]
Acute intestinal amebiasis [DS:H00360]
Acne vulgaris [DS:H01445]

Target

30S ribosomal subunit

Pathway

ko03010

Ribosome

Interaction

Structure map

map07019

Tetracyclines

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AB Antiinfectives and antiseptics for local oral treatment
     A01AB23 Minocycline
      D00850  Minocycline hydrochloride (JP18/USP) <JP/US>
D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF07 Minocycline
      D00850  Minocycline hydrochloride (JP18/USP) <JP/US>
J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01A TETRACYCLINES
    J01AA Tetracyclines
     J01AA08 Minocycline
      D00850  Minocycline hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Antibacterials
  Tetracyclines
   Minocycline
    D00850  Minocycline hydrochloride (JP18/USP)
Dental and Oral Agents
  Minocycline
   D00850  Minocycline hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  27  Dental preparations
   276  Antibiotics
    2760  Antibiotics
     D00850  Minocycline hydrochloride (JP18/USP)
6  Agents against pathologic organisms and parasites
  61  Antibiotics
   615  Acting mainly on gram-positive bacteria, gram-negative bacteria, rickettsia and chlamydia
    6152  Tetracycline antibiotics
     D00850  Minocycline hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Antibacterial
  DG01197  Tetracycline antibiotic
   DG00009  Minocycline
    D00850  Minocycline hydrochloride
Drug classes [BR:br08332]
Antibacterial
  DG01197  Tetracycline antibiotic
   D00850  Minocycline hydrochloride
Antimicrobials [BR:br08307]
Antibacterials
  Protein biosynthesis inhibitor
   Tetracycline
    D00850  Minocycline hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00850  Minocycline hydrochloride
  D00850  Minocycline hydrochloride tablets
  D00850  Minocycline hydrochloride glanules
  D00850  Minocycline hydrochloride for injection
Drug groups [BR:br08330]
Antibacterial
  DG01197  Tetracycline antibiotic
   DG00009  Minocycline
Antimicrobials abbreviations [BR:br08327]
Antibacterials
  Protein biosynthesis inhibitor
   Tetracycline
    DG00009  Minocycline

Other DBs

CAS:	13614-98-7

PubChem:

7847915

ChEBI:

50697

LigandBox:

D00850

NIKKAJI:

J280.738F

KCF data

ATOM        34
            1   C1y C    26.3399  -16.6515
            2   C1z C    26.3516  -18.0316
            3   C1y C    27.5270  -15.9498
            4   C1x C    25.1294  -15.9791
            5   C2y C    25.1703  -18.7451
            6   C5x C    27.5562  -18.7099
            7   O1a O    26.3516  -19.4294
            8   C2y C    28.7958  -16.6281
            9   N1c N    27.5094  -14.5522
            10  C1y C    23.9423  -16.6866
            11  C2y C    23.9657  -18.0667
            12  O1a O    25.1937  -20.1428
            13  C2y C    28.7433  -18.0082
            14  O5x O    27.5679  -20.1134
            15  O1a O    29.9304  -15.9206
            16  C1a C    28.7141  -13.8388
            17  C1a C    26.2931  -13.8681
            18  C1x C    22.7318  -16.0083
            19  C5x C    22.7727  -18.7861
            20  C5a C    29.9597  -18.6982
            21  C8y C    21.5389  -16.7217
            22  C8y C    21.5621  -18.1135
            23  O5x O    22.7261  -20.1836
            24  N1a N    31.1643  -17.9848
            25  O5a O    29.9772  -20.0960
            26  C8y C    20.3108  -16.0434
            27  C8y C    20.3693  -18.8387
            28  C8x C    19.1179  -16.7685
            29  N1c N    20.2874  -14.6458
            30  C8x C    19.1413  -18.1661
            31  O1a O    20.3985  -20.2422
            32  C1a C    21.4862  -13.9264
            33  C1a C    19.0652  -13.9675
            34  X   Cl   34.4400  -16.8000
BOND        36
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9     4  10 1
            10    5  11 2
            11    5  12 1
            12    6  13 1
            13    6  14 2
            14    8  15 1
            15    9  16 1
            16    9  17 1
            17   10  18 1
            18   11  19 1
            19   13  20 1
            20   18  21 1
            21   19  22 1
            22   19  23 2
            23   20  24 1
            24   20  25 2
            25   21  26 1
            26   22  27 1
            27   26  28 2
            28   26  29 1
            29   27  30 2
            30   27  31 1
            31   29  32 1
            32   29  33 1
            33    8  13 2
            34   10  11 1
            35   21  22 2
            36   28  30 1