Chlorhexidine gluconate


Entry
D00858                      Drug                                   
Name
Chlorhexidine gluconate (JP18/USP);
Hibiclens (TN);
Peridex (TN);
Periogard (TN)
Product
BETASEPT (Xttrium Laboratories), PERIDEX (3M ESPE Dental Products), PERIOCHIP (Dexcel Pharma Technologies), PERIDEX (Xttrium Laboratories), ANTISEPTIC SKIN CLEANSER (Xttrium Laboratories)
  Generic
MAJOR ORAL RINSE (Cardinal Health), MAJOR ORAL RINSE (Cardinal Health), MAJOR ORAL RINSE (Major Pharmaceuticals), CHLORHEXIDINE GLUCONANTE (AMD Medicom), DENTI-CARE DENTI-RINSE (Xttrium Laboratories), CHLORHEXIDINE GLUCONATE (A-S Medication Solutions), PAROEX (ATLANTIC BIOLOGICALS CORP.), PERIOGARD ALCOHOL FREE (ATLANTIC BIOLOGICALS CORP.), CHLORHEXIDINE GLUCONATE (American Health Packaging), CHLORHEXIDINE GLUCONATE (Benco Dental), PERIOGARD ALCOHOL FREE (Colgate Oral Pharmaceuticals), PERIOGARD ALCOHOL FREE (Colgate Oral Pharmaceuticals), PERIOGARD (CHLORHEXIDINE GLUCONATE) (Colgate Oral Pharmaceuticals), CHLORHEXIDINE GLUCONATE (Darby Dental Supply), CHLORHEXIDINE GLUCONATE (Den-mat Holdings), NUPRO CHLORHEXIDINE GLUCONATE (Dentsply LLC. Professional Division Trading as "DENTSPLY Professional"), CHLORHEXIDINE GLUCONATE (Lohxa), CHLORHEXIDINE GLUCONATE (Lohxa), CHLORHEXIDINE GLUCONATE (Lyne Laboratories), SKY ORAL RINSE (McKesson), CHLORHEXIDINE GLUCONATE (Medline Industries), CHLORHEXIDINE GLUCONATE (NuCare Pharmaceuticals), CHLORHEXIDINE (NuCare Pharmaceuticals), CHLORHEXIDINE (PINNACLE PHARMA LLC), CHLORHEXIDINE GLUCONATE (Patterson Dental Supply), CHLORHEXIDINE GLUCONATE (Patterson Dental Supply), CHLORHEXIDINE GLUCONATE (Pharmaceutical Associates), CHLORHEXIDINE GLUCONATE (Preferred Pharmaceuticals), CHLORHEXIDINE GLUCONATE (Preferred Pharmaceuticals), CHLORHEXIDINE GLUCONATE (Proficient Rx LP), CHLORHEXIDINE GLUCONATE (Proficient Rx LP), CHLORHEXIDINE GLUCONATE (RPK Pharmaceuticals), CHLORHEXIDINE GLUCONATE (Safecor Health), CHLORHEXIDINE GLUCONATE 0.12% ORAL RINSE (Sage Products LLC), CHLORHEXIDINE GLUCONATE (VistaPharm), CHLORHEXIDINE GLUCONATE (Xttrium Laboratories), CHLORHEXIDINE GLUCONATE (Xttrium Laboratories), CHLORHEXIDINE GLUCONATE (Xttrium Laboratories), CHLORHEXIDINE GLUCONATE (Xttrium Laboratories), CHLORHEXIDINE GLUCONATE 0.12% ORAL RINSE (Xttrium Laboratories), CHLORHEXIDINE GLUCONATE (Xttrium Laboratories), NUPRO CHLORHEXIDINE GLUCONATE (Xttrium Laboratories), DASH CHLORHEXIDINE GLUCONATE 0.12% ORAL RINSE (Cardinal Health), DASH CHLORHEXIDINE GLUCONATE 0.12% ORAL RINSE (Cardinal Health), DASH CHLORHEXIDINE GLUCONATE 0.12% ORAL RINSE (Dash Pharmaceuticals LLC), ACCLEAN CHLORHEXIDINE GLUCONATE 0.12% ORAL RINSE (Henry Schein), ACCLEAN CHLORHEXIDINE GLUCONATE 0.12% ORAL RINSE (Henry Schein), ACCLEAN CHLORHEXIDINE GLUCONATE 0.12% ORAL RINSE (Xttrium Laboratories), ACCLEAN CHLORHEXIDINE GLUCONATE 0.12% ORAL RINSE (Xttrium Laboratories), CHLORHEXIDINE GLUCONATE, 0.12% ORAL RINSE SOLUTION (Bajaj Medical)
Formula
C22H30Cl2N10. (C6H12O7)2
Exact mass
896.3198
Mol weight
897.7572
Structure
Simcomp
Remark
Same as: C08038
Therapeutic category: 2619
ATC code: A01AB03 B05CA02 D08AC02 D09AA12 R02AA05 S01AX09 S02AA09 S03AA04
Chemical structure group: DG00001
Product (DG00001): D00858<JP/US>
Product (mixture): D10301<JP>
Efficacy
Antibacterial, Disinfectant, Cell membrane function inhibitor
Comment
Biguanide
Target
Lipopolysaccharide
Lipoteichoic acid
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AB Antiinfectives and antiseptics for local oral treatment
     A01AB03 Chlorhexidine
      D00858  Chlorhexidine gluconate (JP18/USP) <JP/US>
 B BLOOD AND BLOOD FORMING ORGANS
  B05 BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
   B05C IRRIGATING SOLUTIONS
    B05CA Antiinfectives
     B05CA02 Chlorhexidine
      D00858  Chlorhexidine gluconate (JP18/USP) <JP/US>
 D DERMATOLOGICALS
  D08 ANTISEPTICS AND DISINFECTANTS
   D08A ANTISEPTICS AND DISINFECTANTS
    D08AC Biguanides and amidines
     D08AC02 Chlorhexidine
      D00858  Chlorhexidine gluconate (JP18/USP) <JP/US>
  D09 MEDICATED DRESSINGS
   D09A MEDICATED DRESSINGS
    D09AA Medicated dressings with antiinfectives
     D09AA12 Chlorhexidine
      D00858  Chlorhexidine gluconate (JP18/USP) <JP/US>
 R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AA Antiseptics
     R02AA05 Chlorhexidine
      D00858  Chlorhexidine gluconate (JP18/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AX Other antiinfectives
     S01AX09 Chlorhexidine
      D00858  Chlorhexidine gluconate (JP18/USP) <JP/US>
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA09 Chlorhexidine
      D00858  Chlorhexidine gluconate (JP18/USP) <JP/US>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03A ANTIINFECTIVES
    S03AA Antiinfectives
     S03AA04 Chlorhexidine
      D00858  Chlorhexidine gluconate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Dental and Oral Agents
  Chlorhexidine
   D00858  Chlorhexidine gluconate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   261  Antimicrobial agents
    2619  Others
     D00858  Chlorhexidine gluconate (JP18/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for respiratory organs
  27 Gargles
   D00858  Chlorhexidine gluconate (JP18/USP)
 Agents for integumentary system
  54 Disinfectants (incl. special bandages)
   D00858  Chlorhexidine gluconate (JP18/USP)
  56 Purulent skin remedies
   D00858  Chlorhexidine gluconate (JP18/USP)
 Agents for sanitation
  81 Disinfectants
   D00858  Chlorhexidine gluconate (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Chlorhexidine
    D00858  Chlorhexidine gluconate (JP18/USP)
Animal drugs in Japan [BR:br08331]
 99  Agents for not mainly purpose of therapeutic
  992  Amphoteric soap and preparations
   9929  Other agents for disinfections
    D00858  Chlorhexidine gluconate
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00858  Chlorhexidine gluconate solution
Other DBs
CAS: 18472-51-0
PubChem: 7847923
ChEBI: 28312
LigandBox: D00858
NIKKAJI: J231.135F
KCF data

ATOM        60
            1   C8y C    16.8209  -12.4495
            2   N1b N    18.0443  -13.1396
            3   C8x C    15.6133  -13.1396
            4   C8x C    16.8209  -11.0381
            5   C2c C    19.2438  -12.4338
            6   C8x C    14.4059  -12.4495
            7   C8x C    15.6133  -10.3323
            8   N1b N    20.4592  -13.1396
            9   N2a N    19.2438  -11.0381
            10  C8y C    14.4059  -11.0381
            11  C2c C    21.6746  -12.4338
            12  X   Cl   13.1825  -10.3323
            13  N1b N    22.8901  -13.1396
            14  N2a N    21.6746  -11.0381
            15  C1b C    24.1055  -12.4338
            16  C1b C    25.3287  -13.1396
            17  C1b C    26.5361  -12.4338
            18  C1b C    27.7516  -13.1396
            19  C1b C    28.9670  -12.4338
            20  C1b C    30.1744  -13.1317
            21  N1b N    31.3978  -12.4338
            22  C2c C    32.6053  -13.1317
            23  N1b N    33.8285  -12.4338
            24  N2a N    32.6053  -14.5354
            25  C2c C    35.0362  -13.1317
            26  N1b N    36.2594  -12.4338
            27  N2a N    35.0362  -14.5354
            28  C8y C    37.4669  -13.1317
            29  C8x C    37.4591  -14.5274
            30  C8x C    38.6666  -12.4261
            31  C8x C    38.6666  -15.2176
            32  C8x C    39.8820  -13.1160
            33  C8y C    39.8820  -14.5117
            34  X   Cl   41.0975  -15.2176
            35  C1c C    25.2700  -16.9400
            36  C1c C    26.4600  -17.6400
            37  C1c C    24.0800  -17.6400
            38  O1a O    25.2700  -15.5400
            39  C1c C    27.7200  -16.9400
            40  O1a O    26.4600  -19.0400
            41  C1b C    22.8900  -16.9400
            42  O1a O    24.0800  -19.0400
            43  C6a C    28.9100  -17.6400
            44  O1a O    27.7200  -15.5400
            45  O1a O    21.6300  -17.6400
            46  O6a O    30.1000  -16.9400
            47  O6a O    28.9100  -19.0400
            48  C1c C    25.2700  -16.9400
            49  C1c C    26.4600  -17.6400
            50  C1c C    27.7200  -16.9400
            51  C6a C    28.9100  -17.6400
            52  O6a O    30.1000  -16.9400
            53  O6a O    28.9100  -19.0400
            54  O1a O    27.7200  -15.5400
            55  O1a O    26.4600  -19.0400
            56  C1c C    24.0800  -17.6400
            57  C1b C    22.8900  -16.9400
            58  O1a O    21.6300  -17.6400
            59  O1a O    24.0800  -19.0400
            60  O1a O    25.2700  -15.5400
BOND        59
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 2
            7     5   8 1
            8     5   9 2
            9     6  10 2
            10    8  11 1
            11   10  12 1
            12   11  13 1
            13   11  14 2
            14   13  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   18  19 1
            19   19  20 1
            20   20  21 1
            21   21  22 1
            22   22  23 1
            23   22  24 2
            24   23  25 1
            25   25  26 1
            26   25  27 2
            27   26  28 1
            28   28  29 2
            29   28  30 1
            30   29  31 1
            31   30  32 2
            32   31  33 2
            33   33  34 1
            34    7  10 1
            35   32  33 1
            36   35  36 1
            37   35  37 1
            38   35  38 1 #Up
            39   36  39 1
            40   36  40 1 #Up
            41   37  41 1
            42   37  42 1 #Down
            43   39  43 1
            44   39  44 1 #Up
            45   41  45 1
            46   43  46 1
            47   43  47 2
            48   48  49 1
            49   48  56 1
            50   48  60 1 #Up
            51   49  50 1
            52   49  55 1 #Up
            53   56  57 1
            54   56  59 1 #Down
            55   50  51 1
            56   50  54 1 #Up
            57   57  58 1
            58   51  52 1
            59   51  53 2
BRACKET     1    20.3000  -19.7400   20.3000  -14.8400
            1    31.2200  -14.8400   31.2200  -19.7400
            1  2
 ORIGINAL  1   35  36  39  43  46  47  44  40  37  41  45  42  38
 REPEAT    1   48  49  50  51  52  53  54  55  56  57  58  59  60