Cycloserine


Entry
D00877                      Drug                                   
Name
Cycloserine (JP18/USP/INN);
Seromycin (TN)
  Abbr
DCS
Product
  Generic
CYCLOSERINE (Parsolex Gmp Center), CYCLOSERINE (Parsolex Gmp Center), SEROMYCIN (Parsolex Gmp Center), SEROMYCIN (Parsolex Gmp Center)
Formula
C3H6N2O2
Exact mass
102.0429
Mol weight
102.0919
Structure
Simcomp
Source
Streptomyces lavendulae [TAX:1914], Streptomyces roseochromogenes [TAX:67357]
Class
Antibacterial
 DG01966  Antitubercular
Remark
Same as: C08057
Therapeutic category: 6162
ATC code: J04AB01
Product: D00877<JP/US>
Efficacy
Antibacterial (tuberculostatic), Cell wall biosynthesis inhibitor
  Disease
Tuberculosis [DS:H00342]
Comment
Natural product
Target
D-alanine-D-alanine ligase [KO:K01921]
alanine racemase [KO:K01775]
  Pathway
ko00473  D-Alanine metabolism
ko00550  Peptidoglycan biosynthesis
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J04 ANTIMYCOBACTERIALS
   J04A DRUGS FOR TREATMENT OF TUBERCULOSIS
    J04AB Antibiotics
     J04AB01 Cycloserine
      D00877  Cycloserine (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antimycobacterials
  Antituberculars
   Cycloserine
    D00877  Cycloserine (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   616  Acting mainly on acid-fast bacteria
    6162  Cycloserines
     D00877  Cycloserine (JP18/USP/INN)
Drug groups [BR:br08330]
 Antibacterial
  DG01966  Antitubercular
   D00877  Cycloserine
Antimicrobials [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor, other
   Other peptidoglycan biosynthesis inhibitor
    D00877  Cycloserine (JP18/USP/INN) <JP/US>
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Cell wall biosynthesis inhibitor, other
   Other peptidoglycan biosynthesis inhibitor
    D00877  Cycloserine (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00877  Cycloserine
Other DBs
CAS: 68-41-7
PubChem: 7847941
ChEBI: 40009
PDB-CCD: 4AX[PDBj]
LigandBox: D00877
NIKKAJI: J8.592H
KCF data

ATOM        7
            1   C1x C     7.7000  -17.0800
            2   O2x O     9.1000  -17.0800
            3   N1x N     9.5326  -15.7485
            4   C5x C     8.4000  -14.9256
            5   C1y C     7.2674  -15.7485
            6   O5x O     8.4000  -13.5100
            7   N1a N     5.9478  -15.3197
BOND        7
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     4   6 2
            7     5   7 1 #Up