| Entry |
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|---|---|---|---|---|---|---|---|---|---|---|---|
| Name | Econazole nitrate (JAN/USP); Ecoza (TN); Spectazole (TN) | ||||||||||
| Product | ECOZA (Exeltis USA Dermatology) | ||||||||||
| Generic | ECONAZOLE NITRATE (Bryant Ranch Prepack), ECONAZOLE NITRATE (Bryant Ranch Prepack), ECONAZOLE NITRATE (Bryant Ranch Prepack), ECONAZOLE NITRATE (McKesson Corporation), ECONAZOLE NITRATE (Padagis Israel Pharmaceuticals), ECONAZOLE NITRATE (Preferred Pharmaceuticals), ECONAZOLE NITRATE (Preferred Pharmaceuticals), ECONAZOLE NITRATE (Preferred Pharmaceuticals), ECONAVIX (Primary Pharmaceuticals), ECONAZOLE NITRATE (SOLA Pharmaceuticals), ECONAZOLE NITRATE (Taro Pharmaceuticals U.S.A.), ECONAZOLE NITRATE (Teligent Pharma) | ||||||||||
| Formula | C18H15Cl3N2O. HNO3 | ||||||||||
| Exact mass | 443.0206 | ||||||||||
| Mol weight | 444.6963 | ||||||||||
| Structure |  | ||||||||||
| Simcomp | |||||||||||
| Class | Antifungal DG01883 Imidazole antifungal | ||||||||||
| Remark |
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| Efficacy | Antifungal, Ergosterol biosynthesis inhibitor | ||||||||||
| Disease | Tinea pedis [DS:H01316] | ||||||||||
| Comment | Imidazole derivative | ||||||||||
| Target | sterol 14alpha-demethylase [KO:K05917] | ||||||||||
| Pathway |
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| Interaction | |||||||||||
| Structure map |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] D DERMATOLOGICALS D01 ANTIFUNGALS FOR DERMATOLOGICAL USE D01A ANTIFUNGALS FOR TOPICAL USE D01AC Imidazole and triazole derivatives D01AC03 Econazole D00881 Econazole nitrate (JAN/USP) <US> G GENITO URINARY SYSTEM AND SEX HORMONES G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS G01AF Imidazole derivatives G01AF05 Econazole D00881 Econazole nitrate (JAN/USP) <US> USP drug classification [BR:br08302] Dermatological Agents Topical Anti-infectives Antifungals, dermatological Econazole D00881 Econazole nitrate (JAN/USP) Classification of Japanese OTC drugs [BR:br08313] Agents for integumentary system 58 Ringworm drugs D00881 Econazole nitrate (JAN/USP) Risk category of Japanese OTC drugs [BR:br08312] Second-class OTC drugs Inorganic and organic chemicals Econazole D00881 Econazole nitrate (JAN/USP) Drug groups [BR:br08330] Antifungal DG01883 Imidazole antifungal DG00363 Econazole D00881 Econazole nitrate Drug classes [BR:br08332] Antifungal DG01883 Imidazole antifungal D00881 Econazole nitrate Antimicrobials [BR:br08307] Antifungals Ergosterol biosynthesis inhibitor Imidazole D00881 Econazole nitrate (JAN/USP) <US> Rx-to-OTC switch list in Japan [br08314.html] D00881 Drug groups [BR:br08330] Antifungal DG01883 Imidazole antifungal DG00363 Econazole | ||||||||||
| Other DBs |
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| KCF data | ATOM 28 1 C8y C 31.4185 -15.4000 2 C1c C 31.4185 -13.9998 3 C8y C 30.2051 -16.1001 4 C8x C 32.6377 -16.1001 5 C1b C 32.6320 -13.2940 6 O2a O 30.2109 -13.2940 7 C8x C 30.2051 -17.5003 8 X Cl 28.9799 -15.4000 9 C8x C 32.6377 -17.5003 10 N4y N 33.8395 -14.0057 11 C1b C 28.9975 -13.9998 12 C8y C 31.4185 -18.2061 13 C8x C 34.9615 -13.1665 14 C8x C 34.2804 -15.3203 15 C8y C 27.7898 -13.2940 16 X Cl 31.4068 -19.6006 17 C8x C 36.0888 -13.9773 18 N5x N 35.6767 -15.3073 19 C8x C 26.5822 -13.9998 20 C8x C 27.7898 -11.8938 21 C8x C 25.3628 -13.2940 22 C8x C 26.5822 -11.1937 23 C8y C 25.3628 -11.8938 24 X Cl 24.1435 -11.1937 25 N2b N 25.4971 -18.0254 #+ 26 O1b O 24.2894 -18.7138 27 O3a O 25.4912 -16.6252 28 O3a O 26.7047 -18.7255 #- BOND 29 1 1 2 1 2 1 3 2 3 1 4 1 4 2 5 1 5 2 6 1 6 3 7 1 7 3 8 1 8 4 9 2 9 5 10 1 10 6 11 1 11 7 12 2 12 10 13 1 13 10 14 1 14 11 15 1 15 12 16 1 16 13 17 2 17 14 18 2 18 15 19 1 19 15 20 2 20 19 21 2 21 20 22 1 22 21 23 1 23 23 24 1 24 9 12 1 25 17 18 1 26 22 23 2 27 25 26 1 28 25 27 2 29 25 28 1 |